Results 51 to 60 of about 525,558 (314)
An Ulcerated Reddish Nodule of the Chest: When You See, Think …
Dermatopathology, 2018 A 97-year-old man with a previous personal history of multiple nonmelanoma skin cancers presented with a fast-growing, ulcerated reddish nodule on his chest.
Giulia Maria Ravaioli +4 more
doaj +1 more source
Mcl-1 Inhibition: Managing Malignancy in Multiple Myeloma
Frontiers in Pharmacology, 2021 Multiple myeloma (MM) is a plasma cells neoplasm. The overexpression of Bcl-2 family proteins, particularly myeloid cell leukemia 1 (Mcl-1), plays a critical role in the pathogenesis of MM.
Omar S. Al-Odat +12 more
doaj +1 more source
DACH1 suppresses breast cancer as a negative regulator of CD44. [PDF]
, 2017 Dachshund homolog 1 (DACH1), a key cell fate determination factor, contributes to tumorigenesis, invasion, metastasis of human breast neoplasm. However, the exact molecular mechanisms for the anti-tumor roles of DACH1 in breast carcinoma are still lack ...
Kuang, Dong +6 more
core +2 more sources
BET protein inhibition shows efficacy against JAK2V617F-driven neoplasms [PDF]
Leukemia, 2013 Small molecule inhibition of the BET family of proteins, which bind acetylated lysines within histones, has been shown to have a marked therapeutic benefit in pre-clinical models of mixed lineage leukemia (MLL) fusion protein-driven leukemias. Here, we report that I-BET151, a highly specific BET family bromodomain inhibitor, leads to growth inhibition ...
B S Wyspiańska +16 more
openaire +4 more sources
Evaluation of the activity of the immune system and age-related tissue markers in Turquoise killifish \ud (Nothobranchius furzeri, Jubb 1971) \ud and their role in cell ageing\ud [PDF]
, 2010 Currently the Turquoise Killifish is considered the best animal model suitable for aging research. \ud This annual fish, from south east Africa, shows an exceptionally adaptive behaviour to dry periods: indeed, due to this extreme environmental ...
Di Cicco, Emiliano, Rossi, Giacomo
core
Pediatric Blood &Cancer, EarlyView.ABSTRACT Purpose Retinoblastoma (RB) is the most common pediatric ocular cancer, yet population‐based data on survival and risk factors remain limited. This study aimed to describe survival in a large national RB cohort and identify predictors of death and complications.
Samuel Sassine +14 more
wiley +1 more source
Current Issues in Molecular Biology, 2022 Oral cancer is a malignant neoplasm of oral cavity. It accounts for approximately 5% of all malignant tumors. Approximately 97% of all oral cancers are squamous cell carcinomas, followed by adenocarcinomas, and rarely malignant melanomas.
Tae-Young Kim +6 more
doaj +1 more source
Highly accurate detection of ovarian cancer using CA125 but limited improvement with serum matrix-assisted laser desorption/ionization time-of-flight mass spectrometry profiling [PDF]
, 2010 Objectives: Our objective was to test the performance of CA125 in classifying serum samples from a cohort of malignant and benign ovarian cancers and age-matched healthy controls and to assess whether combining information from matrix-assisted laser ...
Burford, Brian +13 more
core +1 more source
Histology and histopathology, 2018 We evaluated the expression of glutaminolysis-related proteins in Hurthle cell neoplasms (HCN) and follicular neoplasms (FN) of the thyroid, and investigated its clinical implication.Tissue microarrays were constructed from 264 FNs (112 follicular carcinomas [FCs] and 152 follicular adenomas [FAs]) and 108 HCNs (27 Hurthle cell carcinomas [HCCs] and 81
Cha, Yoon Jin +2 more
openaire +4 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács +8 more
wiley +1 more source