Results 61 to 70 of about 232,408 (333)

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Relapse of Pleomorphic Adenoma from Childhood to Adulthood: Case Report

Acta Clinica Croatica, 2017
Pleomorphic adenoma is rarely seen in childhood. After detailed literature search, we did not come across a case of frequent relapse of this benign tumor from childhood to adulthood. The World Health Organization defines relapse of pleomorphic adenoma as
Stjepan Grabovac, Đurđica Đurđica Grabovac, Zrinka Puharić, Vesna Malčić Dalipi   +3 more
doaj   +1 more source

Prognostic factors for hepatocellular carcinoma recurrence.

World Journal of Gastroenterology, 2014
The recurrence of hepatocellular carcinoma, the sixth most common neoplasm and the third leading cause of cancer-related mortality worldwide, represents an important clinical problem, since it may occur after both surgical and medical treatment.
A. Colecchia, R. Schiumerini, A. Cucchetti, M. Cescon, Martina Taddia, G. Marasco, D. Festi   +6 more
semanticscholar   +1 more source

[Radiofrequency ablation for lung neoplasms with isolated postsurgical local 
recurrences or metastases of non-small cell lung cancer].

Zhongguo fei ai za zhi = Chinese journal of lung cancer, 2014
Primary lung cancer is one of the most common malignancies worldwide. Surgical resection remains the first choice for the treatment of early stage non-small cell lung cancer (NSCLC). Relapse after surgery sharply reduces the patient's life expectancy. This relapse is referred to as isolated postsurgical local recurrences or metastases (IPSLROM), which ...
Baodong Liu, Xiuyi Zhi, Kun Qian, Lei Liu, Mu Hu, Yuanbo Li   +5 more
openaire   +4 more sources

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

Molecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton, Russell W. Madison, Candice Francheska B. Tambaoan, Funda Meric‐Bernstam, Christopher J. Sweeney, Razelle Kurzrock, Howard A. Burris III, David R. Spigel, Hanna Tukachinsky, Jason Hughes, Julia Malato, Bongin Yoo, Tania Szado, Cheryl Schwab, Lincoln W. Pasquina, Amaya Gasco, Katja Schulze, Claire F. Friedman   +17 more
wiley   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Comparison of 10-year overall survival between patients with G1 and G2 grade Ta bladder tumors [PDF]

, 2018
To compare long-term overall survival (OS) in patients with G1 and G2 grade Ta bladder cancer after transurethral resection of bladder tumors (TURBTs).
Balan, Daniel, Borda, Angela, Busetto, Gian Maria, Chibelean, Calin Bogdan, Cioffi, Antonio, De Berardinis, Ettore, Del Giudice, Francesco, Ferro, Matteo, Lucarelli, Giuseppe, Martha, Orsolya, Matei, Victor Deliu, Porav-Hodade, Daniel, Pytel, Akos, Sin, Anca, Tataru, Sabin, Vartolomei, Mihai Dorin, Voidezan, Septimiu   +16 more
core   +2 more sources

Colorectal cancer: cross-sectional imaging for staging of primary tumor and detection of local recurrence.

AJR. American journal of roentgenology, 1991
This review describes the use of cross-sectional imaging in the staging of colorectal carcinoma and detection of local recurrence. The contributions of CT, MR imaging, and sonography are discussed and illustrated.
R. Thoeni
semanticscholar   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Surgical recurrence of solitary fibrous tumor of the pleura treated with microwave (MW) thermoablation: A case report

Thoracic Cancer, 2020
Solitary fibrous tumor (SFT) of the pleura is a rare neoplasm which is challenging for clinicians to treat and radiologists to diagnose. Herein, we report a case of recurrence of SFT of the pleura in a 77‐year‐old patient which was diagnosed and ...
Francesco Fiore, Vincenzo Stoia, Francesco Somma   +2 more
doaj   +1 more source