Results 61 to 70 of about 6,353,210 (299)

Assessment for Risk Factors Associated with Local Recurrence in Chordoma [PDF]

, 2015
Background Chordoma is a rare but locally aggressive malignant neoplasm showing notochordal differentiation. The clinical differential diagnoses can be extensive, and definitive diagnosis often relies on histopathologic evaluation.
Abraham, MD, John A., Jiang, MD, PhD, Wei   +1 more
core   +1 more source

Radiofrequency ablation for recurrent hepatocellular carcinoma: 10-year outcomes of local tumor progression vs intrahepatic distant recurrence

Insights into Imaging
Objectives To compare the long-term outcome of radiofrequency ablation (RFA) for local tumor progression (LTP) vs intrahepatic distant recurrence (IDR) in recurrent hepatocellular carcinoma (rHCC), including cases with repeated LTP. Materials and methods
Huan-ling Guo, Jia-qian Yao, Xin Zheng, Tong-yi Huang, Xiao-er Zhang, Rui Zhang, Wen-xin Wu, Xiao-yan Xie, Ming Xu   +8 more
doaj   +1 more source

Invasive head and neck cutaneous squamous cell carcinoma: clinical and histopathological characteristics, frequency of local recurrence and metastasis [PDF]

Anais Brasileiros de Dermatologia, 2014
BACKGROUND: squamous cell carcinoma is the second most common type of skin malignancy and may evolve to regional lymph node and distant metastases. OBJECTIVE: The objective of this study was to evaluate patients with head and neck cutaneous squamous ...
Luiza Vasconcelos, Juliana Carneiro Melo, Hélio Amante Miot, Mariângela Esther Alencar Marques, Luciana Patricia Fernandes Abbade   +4 more
doaj   +1 more source

A rare case of solitary fibrous tumor of the temporal region: 7-year-follow-up clinical-radiographic evaluation and literature review

Oral and Maxillofacial Surgery Cases, 2022
Solitary fibrous tumor is a rare spindle-cell neoplasm of mesenchymal origin. In head and neck region, the tumors present slow-growing masses, often with local compressive symptoms. Although it is generally benign, malignant variants have been identified.
Ugo Consolo, Francesco Diamante, Attilio Carlo Salgarelli, Pierantonio Bellini   +3 more
doaj   +1 more source

Guidelines on parking management : sustainable mobility [PDF]

, 2023
This document is one in a series of documents on Sustainable Mobility and includes other important subjects – Walkability and Accessibility, Shared Transport, Last Mile Transportation and EV Changeover, previously issued by the Local Councils ...
Zammit, Antoine, Local Councils' Association   +1 more
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Relapse of Pleomorphic Adenoma from Childhood to Adulthood: Case Report

Acta Clinica Croatica, 2017
Pleomorphic adenoma is rarely seen in childhood. After detailed literature search, we did not come across a case of frequent relapse of this benign tumor from childhood to adulthood. The World Health Organization defines relapse of pleomorphic adenoma as
Stjepan Grabovac, Đurđica Đurđica Grabovac, Zrinka Puharić, Vesna Malčić Dalipi   +3 more
doaj   +1 more source

Clear cell sarcoma of the esophagus: A rare location

Clinical Case Reports, 2020
Clear cell sarcoma of the esophagus is very rare. The etiology of this neoplasm remains unknown. Confirmed diagnosis requires histopathology with immunochemistry and molecular study.
Yosra Yahyaoui, Yosr Zenzri, Khalil Behi, Nadia Boujelbene, Amina Mokrani, Imen Abbas, Karima Mrad, Amel Mezlini   +7 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source