Results 211 to 220 of about 748,361 (308)

From Leiomyoma to Smooth Muscle Tumor of Uncertain Malignant Potential: A Rare Recurrent Right Retroperitoneal Mass in a Young Male. [PDF]

Cureus
Preetham Y, Thyavihally Y, Gundavda M, Kulkarni B, Shah A.   +4 more
europepmc   +1 more source

Recurrent Malignant Solid Neoplasm [PDF]

, 2020
openaire   +1 more source

Metabolic Reprogramming in Glioblastoma Stem Cells Promotes Radiation Resistance Through a H3K18la/USP30/MBOAT2 Axis

Advanced Science, EarlyView.
LDHA‐driven lactate production in mesenchymal glioma stem cells promotes p300‐dependent H3K18 lactylation, activates USP30 transcription, and stabilizes MBOAT2 to remodel phosphatidylethanolamines toward ferroptosis‐resistant PE‐MUFA species. Disrupting this metabolic–epigenetic–lipid circuit enhances ferroptosis and sensitizes glioblastoma to ...
Zong Miao, Wei Gu, Yimin Ren, Chenfei Lu, Wanzhi Cai, Junnan Lu, Zhongyuan Bao, Yanan Zhou, Rong Li, Ke Jin, Chao Chen, Hongxiang Wang, Lei Xu, Juxiang Chen   +13 more
wiley   +1 more source

A Case Report of Pleomorphic Adenoma of the Lower Lip: An Uncommon Location and a Diagnostic Pitfall. [PDF]

Cureus
Parcharidis E, Paraskevopoulos K, Minotakis D, Poulopoulos K, Poulopoulos A.   +4 more
europepmc   +1 more source

Modification‐Selective Inhibition of Succinate Dehydrogenase a Enables Tumor‐Restricted Mitochondrial Modulation

Advanced Science, EarlyView.
This work identifies acetylation‐dependent SDHA homeostasis as a determinant of tumor‐specific metabolic vulnerability. Guided by this mechanism, a modification‐selective inhibitor, ZPI‐3, selectively targets non‐acetylated SDHA, achieving tumor‐restricted SDH inhibition and effective bladder cancer control. Differential responses in clinical specimens
Kaikai Xu, Lulu Kong, Kebin Ye, Xinlu Bao, Haowen Liu, Ning Wang, Yongming Deng, Wei Wang, Shaohua Wei, Lin Zhou   +9 more
wiley   +1 more source

Cytological Identification of a Rhabdoid Variant of Pancreatic Neuroendocrine Neoplasm. [PDF]

Cytopathology
Okuda M, Mizuguchi K, Mori T, Okawa U, Ikeda H.   +4 more
europepmc   +1 more source

Ferroptosis Suppression by the M6A Reader IGF2BP1 Underlies Gemcitabine Resistance in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
IGF2BP1 promotes gemcitabine resistance in pancreatic cancer by stabilizing m6A‐modified FTH1 transcripts and protecting them in stress granules, thereby suppressing ferroptosis. Pharmacological inhibition of IGF2BP1 disrupts this protective pathway, restores ferroptotic sensitivity, and enhances gemcitabine efficacy in resistant tumors.
Ying‐Qin Zhu, Yue Huang, Jing‐Yuan Ye, Si‐Yuan Lu, Zhi‐De Liu, Ming‐Jian Ma, De‐Liang Fang, Zi‐Yi Zhao, Jin‐Zhao Xie, Jiao Chen, Xiao‐Yu Yin   +10 more
wiley   +1 more source

Pulmonary Neoplasms with Pleuropulmonary Blastoma-like Features in Two Young Labrador Retrievers: Clinicopathological, Molecular and Comparative Characterisation. [PDF]

Vet Sci
van der Weyden L, Francis BA, Olson DR, Schultz KAP, Di Palma S, Ryan T, Kamieniarz K, Miguel-Garces M, Thompson L, Jones R, Nix C, Haugland S, Ortiz AL.   +12 more
europepmc   +1 more source

Recurrent Malignant Endocrine Neoplasm [PDF]

, 2020
openaire   +1 more source

Biochemically Constrained Multi‐Omics Integration Reveals Protein–Metabolite Dependencies Across Diseases

Advanced Science, EarlyView.
ProMetNet introduces a biologically constrained deep learning framework for proteo‐metabolomic integration by embedding Reactome‐derived pathway topology into neural networks. It captures non‐linear molecular dependencies and pathway‐level metabolic reorganization, enabling interpretable discrimination.
Minghui Zhao, Na Zhou, Ruotong Liu, Xiaofei Li, Jian Li, Fuzhong Xue, Qingzhen Hou   +6 more
wiley   +1 more source