Results 91 to 100 of about 726,328 (344)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Chinese Journal of Lung Cancer, 2008 Mediastinal or N2 disease is the most important factor in selecting the optimal treatment strategy in patients without distant metastasis. A direct surgical resection has not generally been accepted as a treatment modality inwhom mediastinal nodal ...
Alper TOKER
doaj
International Brazilian Journal of Urology, 2005 OBJECTIVE: To assess the prognostic value of the percentage of positive fragments (PPF) in biopsies from patients with localized prostate cancer (PCa) undergoing radical prostatectomy.
Alberto A. Antunes +5 more
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Metastatic Cervix Uterine Cancer and Therapeutics Updates: A Case Report and Literature Review
Brazilian Journal of OncologyMetastatic cervical cancer presents new measures related to the association of biological therapies with conventional treatment that varies according to the presence of biomarkers. Based on a case report, we reviewed therapeutic modalities and updates on
Luís Gustavo Ramos Raupp Pereira +7 more
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Morbidity and mortality after neoadjuvant therapy and sleeve lobectomyin N2-disease
Chinese Journal of Lung Cancer, 2008 Background and objective Sleeve resections were introduced to preserve lung function in patients with limited pulmonary reserve. Increasing experience with sleeve resection has reduced the rate of pneumonectomy below 10%.
Corinna LUDWIG +2 more
doaj
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Identification of key genes associated with poor prognosis and neoplasm staging in gastric cancer. [PDF]
Medicine (Baltimore), 2023 Wang S +6 more
europepmc +1 more source
, 2017 Pseudocarcinomatous hyperplasia of the fallopian tubes is an incidental histopathological finding or it causes slight enlargement of tubes. We are reporting a case where 38 years old woman reported with lump abdomen (corresponding to 28 weeks gravid ...
Vishnu Bhartiya, Richa Sharma
core +1 more source