Results 71 to 80 of about 179,703 (257)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

N2 disease in non-small cell lung cancer patients, diagnosis and evaluation: a Turkish chest surgeon's perspective

Chinese Journal of Lung Cancer, 2008
Mediastinal or N2 disease is the most important factor in selecting the optimal treatment strategy in patients without distant metastasis. A direct surgical resection has not generally been accepted as a treatment modality inwhom mediastinal nodal ...
Alper TOKER
doaj  

Transdiagnostic clinical staging in youth mental health: a first international consensus statement

, 2020
Recognizing that current frameworks for classification and treatment in psychiatry are inadequate, particularly for use in young people and early intervention services, transdiagnostic clinical staging models have gained prominence.
Wood, SJ, Conus, P, Elizabeth M. Scott, Marwaha, S, Matcheri S. Keshavan, Jai L. Shah, Nelson, B., Cross, SPM, McGorry, P.D., Henry, C, Barnaby Nelson, Shah, JL, Dost Öngür, Wood, S.J., Marwaha, S., Shane P.M. Cross, Scott, J., Ongur, D, Scott, EM, Keshavan, M.S., Öngür, D., Conus, P., Keshavan, MS, Hickie, I.B., Chantal Henry, Shah, J.L., Hickie, IB, Nelson, B, Yung, AR, Alison R. Yung, Steven Marwaha, Scott, E.M., Jan Scott, Patrick D. McGorry, McGorry, PD, Stephen J. Wood, Yung, A.R., Scott, J, Ian B. Hickie, Philippe Conus, Henry, C.   +40 more
core   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Metastatic Cervix Uterine Cancer and Therapeutics Updates: A Case Report and Literature Review

Brazilian Journal of Oncology
Metastatic cervical cancer presents new measures related to the association of biological therapies with conventional treatment that varies according to the presence of biomarkers. Based on a case report, we reviewed therapeutic modalities and updates on
Luís Gustavo Ramos Raupp Pereira, Luísa Motter Comarú, Micael Guzzon, Eduarda Alberti Lopes Silva, Júlhia Spuldaro Rabuske, Larissa Roberta Negrão, Raíssa dos Santos Copatti, Paulo Roberto Reichert   +7 more
doaj   +1 more source

Prognostic value of the percentage of positive fragments in biopsies from patients with localized prostate cancer

International Brazilian Journal of Urology, 2005
OBJECTIVE: To assess the prognostic value of the percentage of positive fragments (PPF) in biopsies from patients with localized prostate cancer (PCa) undergoing radical prostatectomy.
Alberto A. Antunes, Marcos F. Dall'Oglio, Alexandre C. Sant'Anna, Mario Paranhos, Katia R. M. Leite, Miguel Srougi   +5 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Morbidity and mortality after neoadjuvant therapy and sleeve lobectomyin N2-disease

Chinese Journal of Lung Cancer, 2008
Background and objective Sleeve resections were introduced to preserve lung function in patients with limited pulmonary reserve. Increasing experience with sleeve resection has reduced the rate of pneumonectomy below 10%.
Corinna LUDWIG, Walburga ENGEL-RIEDEL, Erich STOELBEN   +2 more
doaj  

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source