Results 121 to 130 of about 680,873 (331)

Staging Melanocytic Skin Neoplasms Using High-Level Pixel-Based Features [PDF]

, 2020
Mai Ramadan Ibraheem, Shaker El–Sappagh, Tamer Abuhmed, Mohammed Elmogy   +3 more
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Diagnostic Endoscopic Ultrasound: Technique, Current Status and Future Directions

Gut and Liver, 2018
Endoscopic ultrasound (EUS) is now well established as an important tool in clinical practice. From purely diagnostic imaging, it has progressed to include tissue acquisition, which provided the basis for therapeutic procedures.
Tiing Leong Ang, Andrew Boon Eu Kwek, Lai Mun Wang   +2 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Extensive Intramedullary Spread of Oral Squamous Cell Carcinoma with Minimal Intraoral Manifestation: A Case Report

Journal of Clinical and Diagnostic Research
Globally, Oral Squamous Cell Carcinoma (OSCC) is a significant public health problem, especially in developing countries, where delayed diagnosis often leads to advanced-stage presentation and poor outcomes. OSCC typically presents with visible intraoral
Kundan Shibjee Jha, Nitin Bhola, Sanjana Wadewale   +2 more
doaj   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Klasifikacija i stadijumi melanoma kože [PDF]

Vojnosanitetski Pregled, 2003
Panajotović Ljubomir
doaj   +1 more source

Endoscopic ultrasound in the pre-therapeutic staging of gastroesophageal adenocarcinoma: the diagnostic value in defining patients eligible for a neoadjuvant chemotherapy regimen

Videosurgery and Other Miniinvasive Techniques, 2010
Introduction: Neoadjuvant chemotherapy regimens have been proven to decrease tumour size and stage and significantlyimprove progression-free and overall survival in the treatment of locoregional advanced gastroesophagealadenocarcinomas.
Wilko Staiger, Ulrich Ronellenfitsch, Ralf-Dieter Hofheinz, Philipp Ströbel, Miriam Hahn, Stefan Post, Peter Collet, Georg Kähler, Matthias Schwarzbach   +8 more
doaj  

Low accuracy of endoscopic ultrasonography for detailed T staging in gastric cancer

World Journal of Surgical Oncology, 2012
Background The accuracy of endoscopic ultrasonography (EUS) for preoperative staging of gastric cancer varies. The aim of this study was to investigate the accuracy of EUS tumor (T) and node (N) staging, and to identify the histopathological factors ...
Lee Han, Lim Chul, Park Jae, Cho Yu, Song Kyo, Jeon Hae, Park Cho   +6 more
doaj   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source