Results 131 to 140 of about 179,703 (257)

The IASLC lung cancer staging project : external validation of the revision of the TNM stage groupings in the eighth edition of the TNM classification of lung cancer

, 2017
: Introduction Revisions to the TNM stage classifications for lung cancer, informed by the international database (N = 94,708) of the International Association for the Study of Lung Cancer (IASLC) Staging and Prognostic Factors Committee, need external ...
Detterbeck, Frank C, Nicholson, Andrew G., Crowley, John J, Rami-Porta, Ram\uf3n, Chansky, Kari, Krasnik, Mark, Shemanski, Lynn, Valli\ue8res, Eric, Kennedy, Catherine, Rami-Porta, Ramón, Asamura, Hisao, Nicholson, Andrew G, Rusch, Valerie W, Groome, Patti, Peake, Michael, Bolejack, Vanessa, Vallières, Eric, Rusch, Valerie W., Jakobsen, Erik, Detterbeck, Frank C., Crowley, John J.   +20 more
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Risk factors for intraductal papillary mucinous neoplasm (IPMN) of the pancreas: a multicenter case-control study.

, 2013
Risk factors for intraductal papillary mucinous neoplasm (IPMN) of the ...
SALVIA, Roberto, Intraductal Papillary Mucinous Neoplasm Study Group, Delle Fave G, Capurso G, BASSI, Claudio, Pezzilli R, Boccia S, Boggi U, Zerbi A, Fabbri C, Ventrucci M, Piciucchi M, Manta R, Carnuccio A, Arcidiacono PG, Tarantino I, FRULLONI, Luca, Leoncini E, Larghi A, Del Chiaro M, Costamagna G, Italian Association for Study of Pancreas   +21 more
core  

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Survival of patients with mucosal melanoma in Cali, Colombia: a retrospective cohort study

BMC Cancer
Background Mucosa melanoma is a rare condition with aggressive behavior and a less favorable prognosis compared to cutaneous melanoma. The objective of this study was to estimate the overall survival and clinical outcomes of patients diagnosed with ...
Ana M. García, Luis G. Parra-Lara, Diana M. Mendoza-Urbano, Juan C. Bravo, Ángela Zambrano Harvey   +4 more
doaj   +1 more source

Need for Staging Investigations in Newly Diagnosed Breast Cancer: Establishing Local Guidelines for Radiological Staging in Bahrain

Objective: Staging workup and detection of distant metastases is important in newly diagnosed breast cancer in order to make treatment decisions and establish the prognosis. There is wide variation in current recommendations for staging investigations in
Aysha Adnan Alsadoon, Tareq Hamed Altaei, Raja Eid, Noora Fuad Ali, Hussain Adnan Abdulla, Ahmed Zuhair Salman, Wegdan Zaki Albati, Ahmed Adel Alkazaz, Hisham Mustafa Habib, Sayed Ali Almahari, Noor Ali Almawlani, Fatema Ali Alkhabbaz   +11 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

The ITMIG/IASLC thymic epithelial tumors staging project : a proposed lymph node map for thymic epithelial tumors in the forthcoming 8th edition of the TNM classification of malignant tumors

, 2014
: Although the presence of nodal disease is prognostic in thymic malignancy, the significance of the extent of nodal disease has yet to be defined. Lymph node dissection has not been routinely performed, and there is currently no node map defined for ...
Bhora, Faiz Y., van Schil, Paul, Chen, David J., Detterbeck, Frank C., et al.   +4 more
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