Results 221 to 230 of about 615,914 (313)

IGF1/IGF-1R promotes hepatocellular carcinoma progression by activating the Akt/GSK-3β pathway. [PDF]

PLoS One
Liang J, Song X, Liu Y, Yang G, Zhu B, Tang X.   +5 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Epidemiology of ocular pathology in domestic animals: insights from a 20-year retrospective study. [PDF]

Front Vet Sci
Garcia JM, Rogerio GDS, Rossatto-Júnior CA, Bezerra LS, Schulz ÉT, de Morais RAL, Dagli MLZ.   +6 more
europepmc   +1 more source

Analysing Entity Type Variation across Biomedical Subdomains [PDF]

, 2012
Ananiadou, Sophia, Batista-Navarro, Riza Theresa, Mihaila, Claudiu   +2 more
core  

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Effect of artificial intelligence-assisted personalized feedback on radiographic diagnostic performance of dental students: a controlled study. [PDF]

BMC Med Educ
Gokkurt Yilmaz BN, Ozbey F, Yilmaz BE.
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

The pathogenesis of therapy-related myeloid neoplasms from TP53-mutant clonal hematopoiesis. [PDF]

Leukemia
Fullin J, Topçu E, Zielińska KA, Schimmer RR, Klemm N, Koch C, Caiado F, Lock M, Doerdelmann C, Bühler MM, Tchinda J, Kurppa KJ, Borsig L, Jones PH, Lopes M, Manz MG, Boettcher S.   +16 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Repurposing mebendazole to reprogram oncogenic and tumor-suppressor networks: Multi-cancer insights from ENOX2, MMP2, RASSF1A, WFDC10A and METTL7A. [PDF]

PLoS One
Aqel RS, Ismail AS, El-Tanani M, Satyam SM.   +3 more
europepmc   +1 more source