Results 161 to 170 of about 24,318 (219)

Gut microbiota metabolism of branched‐chain amino acids and their metabolites can improve the physiological function of aging mice

open access: yesAging Cell, Volume 24, Issue 4, April 2025.
Parabacteroides merdae in gut microbiota metabolizes branched‐chain amino acids into isovalerate, 2‐methylbutyrate, and isobutyrate, with key gene porA being less abundant in unhealthy elderly. Parabacteroides merdae and its three BSCFAs improve physiological functions in aging mice, with preliminary mechanism exploration through microbiome ...
Hongchao Wang   +5 more
wiley   +1 more source

Telomerase reverse transcriptase gene knock‐in unleashes enhanced longevity and accelerated damage repair in mice

open access: yesAging Cell, Volume 24, Issue 4, April 2025.
Tert knock‐in (TertKI) mice harboring the EF1α‐Tert gene in the Rosa26 locus displayed heightened telomerase activity, elongated telomeres, and extended lifespan. TertKI mice displayed enhanced wound healing and exhibited resistance to the progression of colitis.
Tian‐Yi Zhu   +9 more
wiley   +1 more source

Circadian Gene BMAL1 Regulation of Cellular Senescence in Thyroid Aging

open access: yesAging Cell, EarlyView.
BMAL1 downregulation during aging reduces NFKBIA expression, accelerating thyroid cellular senescence and impairing hormone synthesis. Circadian rhythm disruption exacerbates thyroid functional decline, highlighting the BMAL1‐NFKBIA axis as a key mediator of aging‐related thyroid dysfunction and offering insights for stabilizing thyroid health in aging
Dandan Zong   +4 more
wiley   +1 more source

Clinicopathology and treatment of a giant malignant phyllodes tumor of the breast: A case report and literature review [PDF]

open access: yes, 2017
Akhilesh, Meenakshi   +9 more
core   +2 more sources

Aggressive Neoplasms That Mimic Chronic Endodontic Lesions: A Multi‐Institutional Case Series

open access: yesAustralian Endodontic Journal, EarlyView.
ABSTRACT This study aimed to report sociodemographic, clinicopathologic and radiological features of 12 cases of aggressive neoplasms that were clinically diagnosed as chronic endodontic lesions. The series comprised seven females (58.33%) and five males (41.67%), with a mean age of 48.9 ± 19.19 years (range: 16–75 years).
Natália Gonçalves Macedo   +11 more
wiley   +1 more source

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