Results 81 to 90 of about 319,310 (259)

Adenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study

FEBS Open Bio, EarlyView.
The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli, Andrea Spinaci, Cui Chang, Rosaria Volpini, Catia Lambertucci, Matteo Landriscina, Vincenza Conteduca, Consuelo Amantini, Cristina Aguzzi, Laura Zeppa, Martina Giangrossi, Laura Soverchia, Matteo Santoni, Massimo Nabissi, Giorgio Santoni, Carlo Polidori   +15 more
wiley   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies

Aging and Cancer, EarlyView.
This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal, Abhimanyu Chiraparambil Radhakrishnan, Ayanchetty Haripraba, Saif Syed, Gajawada Pragna, Ayush Dwivedi, Akash Rawat, Daniela Castro Calderón, Martin Cevallos‐Cueva   +8 more
wiley   +1 more source

Radiotherapy-induced malignancies: Review of clinical features, pathobiology and evolving approaches for mitigating risk

Frontiers in Oncology, 2013
One of the most significant effects of radiation therapy on normal tissues is mutagenesis, which is the basis for radiation-induced malignancies. Radiation-induced malignancies are late complications arising after radiotherapy, increasing in frequency ...
Steve eBraunstein, Jean L Nakamura
doaj   +1 more source

Left hippocampus sparing model for glioblastoma radiotherapy by utilizing knowledge‐based planning and multi‐criteria optimization

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose Results of a prospective, randomized controlled trial at our institute demonstrate an association between the dose to the left hippocampus and neurocognitive decline post‐radiotherapy for patients with glioblastoma. To minimize the dose to the left hippocampus, a left hippocampus sparing model was created using RapidPlan (RP) and multi‐
Shima Y. Tari, Amr Heikal, Connie Le, Fan Yang, Deepak Dinakaran, John Amanie, Albert Murtha, Lindsay S. Rowe, Wilson H. Roa, Samir Patel   +9 more
wiley   +1 more source

Radiation-associated angiosarcoma of the brain with repeated intracerebral hemorrhage: A case report

Interdisciplinary Neurosurgery, 2021
Background: Delayed side effects of irradiation to the brain are now known to include the induction of new neoplasms. Radiation-induced angiosarcoma of the central nervous system is extremely rare.
Fumihisa Kishi, Ryosuke Matsuda, Mitsutoshi Nakamura, Yoshiaki Takamura, Ichiro Nakagawa, Yasushi Motoyama   +5 more
doaj  

The effect of kV imaging dose on PTV and OAR planning constraints in lung SBRT using stereoscopic/monoscopic real‐time tumor‐monitoring system

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose Quantify the impact of additional imaging doses on clinical dose constraints during lung stereotactic body radiotherapy (SBRT) treatment utilizing stereoscopic/monoscopic real‐time tumor monitoring. Materials and Methods Thirty lung SBRT patients treated with the volumetric arc therapy technique were randomly selected from the ...
Ruwan Abeywardhana, Mike Sattarivand
wiley   +1 more source

Evaluation of daily residual pancreatic tumor motion for deep‐inspiration breath‐hold radiotherapy

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose Breath‐hold techniques are widely used in radiation therapy to minimize respiratory‐induced tumor or organ‐at‐risk motion. However, residual motion persists, necessitating a reliable daily evaluation method. Methods At our institution, fiducial markers serve as surrogates for target localization in pancreatic cancer treatment.
Weihua Mao, Binbin Wu, Kai Ding, Sarah Han‐Oh, Amol Narang   +4 more
wiley   +1 more source

Does dose calculation algorithm affect the dosimetric accuracy of synthetic CT for MR‐only radiotherapy planning in brain tumors?

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose This study compares the dosimetric accuracy of deep‐learning‐based MR synthetic CT (sCT) in brain radiotherapy between the Analytical Anisotropic Algorithm (AAA) and AcurosXB (AXB). Additionally, it proposes a novel metric to predict the dosimetric accuracy of sCT for individual post‐surgical brain cases.
Jeffrey C. F. Lui, Francis K. H. Lee, C. C. Law, James C. H. Chow   +3 more
wiley   +1 more source