Results 191 to 200 of about 1,398,433 (359)

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

GRP94 promotes anoikis resistance and peritoneal metastasis through YAP/TEAD1 pathway in gastric cancer

iScience
Summary: Anoikis resistance allows cancer cells to avoid death caused by detachment from the extracellular matrix’s adhesion, enabling these cells to infiltrate and migrate to regions such as the peritoneum.
Qimeng Shi, Yang Lu, Yutong Du, Ruixin Yang, Yingxin Guan, Ranlin Yan, Yingyan Yu, Zhenqiang Wang, Chen Li   +8 more
doaj  

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

Molecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan, Moshe Leitner, Amos Toren, Shoshana Paglin, Michal Yalon   +4 more
wiley   +1 more source

A Moot Thyroid Neoplasm

, 1958
Joseph A. Buckwalter, Carleton D. Nordschow   +1 more
openalex   +2 more sources

NOTES AND SPECIMENS OF A CASE OF INTRA-ORBITAL NEOPLASM [PDF]

, 1923
N. C. Ridley
openalex   +1 more source

Metabolic Risk Factors at the Time of Cancer Diagnosis in Primary Care: A Cross-Sectional Study. [PDF]

Cureus
Brukało K, Szostak M, Slowik J.
europepmc   +1 more source

Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

Molecular Oncology, EarlyView.
In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella, Giuseppina Comito, Luigi Ippolito, Erica Pranzini, Marta Iozzo, Giulia Gangarossa, Francesca Virgilio, Silvia Bua, Alessio Nocentini, Giada Sandrini, Nicla Lorito, Marina Bacci, Gabriella Nesi, Pietro Spatafora, Sergio Serni, Claudiu T. Supuran, Andrea Morandi, Paola Chiarugi, Elisa Giannoni   +18 more
wiley   +1 more source

Chemically contaminated aquatic food resources and human cancer risk: retrospective [PDF]

, 1991
Dawe, C. J., Farrington, J. W., Fouts, J. R., Harshbarger, J. C., Murchelano, R. A., Ozonoff, D., Pritchard, J. B., Stegeman, J. J.   +7 more
core   +1 more source

Intrathoracic Neoplasm.—Post-Mortem Report on Case Previously Shown.—Specimen (Lymphosarcoma) [PDF]

, 1929
F. J. Poynton
openalex   +1 more source

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
wiley   +1 more source