Results 211 to 220 of about 2,439,563 (414)

Uterine Neoplasms, Version 1.2018, NCCN Clinical Practice Guidelines in Oncology.

open access: yesThe Journal of the National Comprehensive Cancer Network, 2018
W. Koh   +33 more
semanticscholar   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

open access: yesMolecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou   +12 more
wiley   +1 more source

Are thrombosis, progression, and survival in ET predictable?

open access: yesBlood Cancer Journal
Ghaith Abu-Zeinah   +7 more
doaj   +1 more source

Homologous recombination repair germline variants and subsequent neoplasm risk among childhood cancer survivors. [PDF]

open access: yesJNCI Cancer Spectr
Zamani SA   +7 more
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

Multiple malignant primary tumors in dogs: an Italian registry-based epidemiological study. [PDF]

open access: yesFront Vet Sci
Crescio MI   +17 more
europepmc   +1 more source

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