Results 231 to 240 of about 1,822,518 (269)

Developmentof Macrocyclic Peptide-Based ProteasomeInhibitors with Enhanced Blood-Brain Barrier Penetration for TreatingBrain Neoplasms

Jehad Almaliti (1562104), Momen Al-Hindy (18882339), Pavla Fajtová (9629462), Evgenia Glukhov (1462093), Theodore Berger (22211016), Yan Graf (22211019), Cesar Emiliano Hoffmann da Silva (22211022), Chandler Huang (22211025), Narek Azizyan (22211028), Yuxian He (277042), Anthony J. O’Donoghue (7206356), William H. Gerwick (176359)   +11 more
openalex   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Synchronous Triple Primary Gastrointestinal Tract Malignancies: A Case Report. [PDF]

Korean J Helicobacter Up Gastrointest Res
Rim HM, Rah YM, Kim JS.
europepmc   +1 more source

PATIENTS WITH METASTATIC GESTATIONAL TROPHOBLASTIC NEOPLASMS AND NO GYNECOLOGICAL SYMPTOMS

, 2008
F. Ghaemmaghami T. Ashraf Ganjoie
openalex   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Network Analysis of Predicted Therapeutic Symptoms in National Health Insurance Herbal Prescriptions. [PDF]

Life (Basel)
Jang S, Lee A, Kho C.
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Ultrasonographic and computed tomographic findings of an intra-abdominal lipoma in a dog. [PDF]

Vet Res Commun
da Silva Mattos MPL, Stolf LC, Carneiro RK.   +2 more
europepmc   +1 more source

Global burden and trends analysis of common cancers attributable to dietary risks from 1990 to 2021 and projection to 2050: a secondary analysis for the global burden of disease study 2021. [PDF]

Front Nutr
Wei T, Li Y, Zhang Z, Xu Y, Huang H, Huang Y, Li J, Gong Z, Hu Z, Wang Y, Zhang A, Li F.   +11 more
europepmc   +1 more source