Results 181 to 190 of about 1,996,477 (249)

Complex Genetic Architecture in RASopathies: Constitutional PTPN11 and Mosaic RIT1 Pathogenic Variants Underlying Severe Noonan Syndrome With Adult‐Onset Acute Myeloid Leukemia

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Noonan syndrome (NS) is a genetically heterogeneous disorder characterized by a broad spectrum of clinical features resulting from dysregulation of the RAS/MAPK pathway. Although complex genotypes are increasingly recognized in NS, cases harboring two distinct pathogenic variants in different NS genes remain extremely rare.
Francesco Prevedello, Dario Seif Ali, Chiara Piccolo, Chiara Rigon, Monica Forzan, Elena Tacchetto, Roberta Palmitessa, Davide Calosci, Leonardo Salviati, Carmela Gurrieri, Eva Trevisson   +10 more
wiley   +1 more source

Metastatic potential of ovine pulmonary adenocarcinoma: a comprehensive assessment of the draining pulmonary lymph nodes. [PDF]

J Vet Diagn Invest
Hodor D, Negoescu A, Pop R, Popa R, Borfalău C, Hașaș AD, Cazan CD, Savage J, Cousens C, Aharoni K, Hilbe M, Rosato G, Dumitru I, Olech M, Bocăneț VI, Cătoi C, Taulescu M, Toma C.   +17 more
europepmc   +1 more source

Altered Nasal Microbiota in Sinonasal Tumors: A Comparative Analysis of Malignant and Benign Sinonasal Tumors

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Although shifts in nasal microbiota have been well‐documented in inflammatory upper airway conditions, microbiota tumor‐associated alterations remain uncharacterized. This study is the first to compare sinonasal microbiota profiles of patients with malignant tumors (MT), benign tumors (BT), and controls, offering insights into tumor‐
Evan A. Patel, Phillip A. Engen, Glen D. Souza, Sarah Khalife, Donyea Moore, Lauren Kret, Pedro Escobedo, Stefan J. Green, Ankur Naqib, Peter Filip, Peter Papagiannopoulos, Bobby A. Tajudeen, Mahboobeh Mahdavinia, Pete S. Batra   +13 more
wiley   +1 more source

Sarcoma at the Site of a Transponder Implant in a Standing's Day Gecko (<i>Phelsuma standingi</i>): A Case Report. [PDF]

Case Rep Vet Med
Thompson MV, Kell T, Keller SM, Rosario J, Gjeltema J.   +4 more
europepmc   +1 more source

Zebrafish and CRISPR—A synergistic approach to decipher and cure human diseases

Animal Models and Experimental Medicine, EarlyView.
Zebrafish, with high genetic homology to humans, serves as a powerful vertebrate model for disease modeling and drug discovery. Integration of CRISPR/Cas9 technology enables precise genome editing, facilitating the development of translational models for human diseases.
Manikandan Sivaprakasam, Aashika Raagavi Jeanpierre, Salma Mohammed, Rajesh Srinivasan, Aman Kumar Mohanty   +4 more
wiley   +1 more source

Histopathologic Findings in Three Dogs With Metastatic Carcinoma Presenting With Bronchovascular Bundle Thickening on Computed Tomography. [PDF]

Vet Radiol Ultrasound
Wise R, Mulvihill M, Reetz J, Pfisterer B, Mai W.   +4 more
europepmc   +1 more source

Molecular characterization of the A52 murine hepatocellular carcinoma cell line

Animal Models and Experimental Medicine, EarlyView.
Hepatocellular carcinoma (HCC) is a poor outcome cancer with limited therapeutic choices. To advance therapeutic development we genetically characterized the A52 murine HCC cell line. We noted genetic changes that match a subset of human HCC and this offers the opportunity to test novel targeted therapies in syngeneic mice.
Rhys Gillman, Eun Jin Sun, Miriam Wankell, Matt A. Field, Ulf Schmitz, Lionel Hebbard   +5 more
wiley   +1 more source

Tonsillar T-cell lymphoma with hepatic and renal metastases in a fattening domestic pig (Sus scrofa domesticus). [PDF]

BMC Vet Res
Giglia G, Minelli L, D'Avino N, Ranucci A, Lepri E, Manuali E.   +5 more
europepmc   +1 more source

Skeletal pathologies in extant crocodilians as a window into the paleopathology of fossil archosaurs

The Anatomical Record, EarlyView.
Abstract Crocodilians, together with birds, are the only extant relatives to many extinct archosaur groups, making them highly important for interpreting paleopathological conditions in a phylogenetic disease bracketing model. Despite this, comprehensive data on osteopathologies in crocodilians remain scarce.
Alexis Cornille, Kyla Beguesse, Ewan Wolff, Clemens Zinner, Patrick Asbach, François Clarac, Florian Witzmann   +6 more
wiley   +1 more source

Frequency Distribution of Neoplastic and Non-neoplastic Thyroid Lesions in Relation to Patient Age and Gender. [PDF]

Cureus
Jamil Z, Sadaf S, Batool S, Iqbal S, Shakeel M, Shuja S.   +5 more
europepmc   +1 more source