Results 1 to 10 of about 6,825,361 (206)

Dendrosomal nanocurcumin prevents EBV-associated cell transformation by targeting the lytic cycle genes of the Epstein-Barr virus in the generation of lymphoblastoid cell line [PDF]

open access: yesIranian Journal of Basic Medical Sciences, 2023
Objective(s): Targeting the lytic cycle of the Epstein-Barr virus (EBV) has been considered a new treatment strategy for malignancies caused by this virus.
Mahboobeh Cheragh   +3 more
doaj   +1 more source

Diffuse osteolytic lesions in leukemic transformation of myelofibrosis [PDF]

open access: yesArchive of Oncology, 2007
Myelofibrosis is a clonal myeloproliferative disorder characterized by splenomegaly, abnormal deposition of reticulin and collagen in the bone marrow, extramedullary hematopoiesis, dacryocytosis and leukoerythroblastic blood smear.
Jurišić Vladimir   +3 more
doaj   +1 more source

New Sesquiterpene Glycosides from the Flowers of Aster koraiensis and Their Inhibition Activities on EGF- and TPA-Induced Cell Transformation

open access: yesPlants, 2023
In total, four new eudesmane-type sesquiterpene glycosides, askoseosides A–D (1–4), and 18 known compounds (5–22) were isolated from the flowers of Aster koraiensis via chromatographic techniques.
Young-Hye Seo   +11 more
doaj   +1 more source

The Diarylheptanoid Curcumin Induces MYC Inhibition and Cross-Links This Oncoprotein to the Coactivator TRRAP

open access: yesFrontiers in Oncology, 2021
The c-Myc protein (MYC) is a transcription factor with strong oncogenic potential controlling fundamental cellular processes. In most human tumors, MYC is overexpressed by enhanced transcriptional activation, gene amplification, chromosomal ...
Alexander Mödlhammer   +4 more
doaj   +1 more source

Enhanced Biomass and Astaxanthin Production of Haematococcus pluvialis by a Cell Transformation Strategy with Optimized Initial Biomass Density

open access: yesMarine Drugs, 2020
Astaxanthin from H. pluvialis is an antioxidant and presents a promising application in medicine for human health. The two-stage strategy has been widely adopted to produce astaxanthin by the Haematococcus industry and research community.
Feng Li   +9 more
doaj   +1 more source

Phosphorylation of tyrosine 90 in SH3 domain is a new regulatory switch controlling Src kinase

open access: yeseLife, 2023
The activation of Src kinase in cells is strictly controlled by intramolecular inhibitory interactions mediated by SH3 and SH2 domains. They impose structural constraints on the kinase domain holding it in a catalytically non-permissive state.
Lenka Koudelková   +9 more
doaj   +1 more source

MicroRNAs as a Suitable Biomarker to Detect the Effects of Long-Term Exposures to Nanomaterials. Studies on TiO2NP and MWCNT

open access: yesNanomaterials, 2021
The presence of nanomaterials (NMs) in the environment may represent a serious risk to human health, especially in a scenario of chronic exposure. To evaluate the potential relationship between NM-induced epigenetic alterations and carcinogenesis, the ...
Sandra Ballesteros   +6 more
doaj   +1 more source

Novel Therapeutic Approaches for KRAS-Mutated Lung Cancer Involving LZTR1 Genetic Alteration

open access: yesMedical Sciences Forum, 2023
A total of 30% of lung adenocarcinoma are driven by activating KRAS mutations. The treatment options for KRAS-mutant lung cancer are still limited as a challenge for therapy is the high heterogeneity within KRAS mutant tumors.
Raj N. Sewduth   +3 more
doaj   +1 more source

E6/E7 Functional Differences among Two Natural Human Papillomavirus 18 Variants in Human Keratinocytes

open access: yesViruses, 2021
It is suggested that HPV-18 variants from the A lineage have higher oncogenic potential compared to B variants. Some studies show uneven distribution of HPV-18 variants in cervical adenocarcinomas and squamous cell carcinomas.
Emily Montosa Nunes   +9 more
doaj   +1 more source

The Emerging Role of miRNAs in HTLV-1 Infection and ATLL Pathogenesis

open access: yesViruses, 2015
Human T-cell leukemia virus (HTLV)-1 is a human retrovirus and the etiological agent of adult T-cell leukemia/lymphoma (ATLL), a fatal malignancy of CD4/CD25+ T lymphocytes.
Ramona Moles, Christophe Nicot
doaj   +1 more source

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