Association Between Simian Virus 40 and Human Tumors [PDF]
Frontiers in Oncology, 2019 Simian virus 40 (SV40) is a small DNA tumor virus of monkey origin. This polyomavirus was administered to human populations mainly through contaminated polio vaccines, which were produced in naturally infected SV40 monkey cells.
John Charles Rotondo +4 more
doaj +2 more sources
Comparing a new method for mapping nucleosomes in simian virus 40 chromatin to standard procedures [PDF]
Epigenetics, 2021 The location of nucleosomes in chromatin significantly impacts many biological processes including DNA replication, repair, and gene expression. A number of techniques have been developed for mapping nucleosome locations in chromatin including MN-Seq ...
Barry Milavetz +2 more
doaj +2 more sources
Interferon-γ production in response to the cytotoxic T lymphocyte epitope within an antigen incorporated in simian virus 40 virus-like particles [PDF]
HeliyonIn a previous study, we showed that administration of antigen-incorporated virus-like particles (VLPs) derived from simian virus 40 (SV40) induces production of cytotoxic T lymphocytes (CTL), as well as antibodies against the incorporated antigen(s ...
Takeharu Watanabe +5 more
doaj +2 more sources
Serum IgG Antibodies from Pregnant Women Reacting to Mimotopes of Simian Virus 40 Large T Antigen, the Viral Oncoprotein [PDF]
Frontiers in Immunology, 2017 Simian virus 40 (SV40) large T antigen (LT) coding sequences were revealed in different human samples, whereas SV40 antibodies (Ab) were detected in human sera of cancer patients and healthy individuals, although with a lower prevalence. Previous studies
Elisa Mazzoni +11 more
doaj +2 more sources
Computational design of a multiepitope vaccine targeting VP1 and VP2 capsid proteins of simian virus 40 (SV40) for enhanced immune activation [PDF]
Open MedicineThis study aimed to design and evaluate a computationally constructed multiepitope vaccine targeting Simian Virus 40 (SV40) by predicting and selecting immunogenic B-cell and T-cell epitopes derived from the VP1 and VP2 capsid proteins using ...
Naveed Muhammad +10 more
doaj +2 more sources
How Simian Virus 40 Hijacks the Intracellular Protein Trafficking Pathway to Its Own Benefit … and Ours [PDF]
Frontiers in Immunology, 2018 Viruses efficiently transfer and express their genes in host cells and evolve to evade the host’s defense responses. These properties render them highly attractive for use as gene delivery vectors in vaccines, gene, and immunotherapies. Among the viruses
Miguel G. Toscano, Peter de Haan
doaj +2 more sources
Corrigendum: Serum IgG antibodies from pregnant women reacting to mimotopes of Simian virus 40 large T antigen, the viral oncoprotein [PDF]
Frontiers in Immunology, 2023 Elisa Mazzoni +11 more
doaj +2 more sources
Neutralizing and IgG antibodies against simian virus 40 in healthy pregnant women in Italy. [PDF]
PLoS ONE, 2014 Polyomavirus simian virus 40 (SV40) sequences have been detected in various human specimens and SV40 antibodies have been found in human sera from both healthy individuals and cancer patients. This study analyzed serum samples from healthy pregnant women
Manola Comar +4 more
doaj +2 more sources
Serum Antibodies Against Simian Virus 40 Large T Antigen, the Viral Oncoprotein, in Osteosarcoma Patients [PDF]
Frontiers in Cell and Developmental Biology, 2018 Human osteosarcoma (OS) is a rare human cancer, mostly occurring in children and adolescents. Simian virus 40 (SV40 = Macaca mulatta polyomavirus 1) sequences have been detected in different human cancers, including osteosarcoma.
Elisa Mazzoni +12 more
doaj +2 more sources
Characterization of doxycycline-dependent inducible Simian Virus 40 large T antigen immortalized human conjunctival epithelial cell line. [PDF]
PLoS ONE, 2019 PurposeTo present the properties of a newly developed immortalized human conjunctival epithelial cell (iHCjEC) line.MethodsiHCjECs were developed to induce Simian Virus 40 large T-antigen (SV40LT) by incorporating lentivirus in a tetracycline (Tet ...
Arisa Mitani +8 more
doaj +2 more sources