Simian virus 40 and cancer [PDF]
Oncology Reviews, 2011 Since its discovery in 1960 as a contaminant of poliovaccines, Simian Virus 40 (SV40) has been the object of extensive studies to assess whether this oncogenic virus plays a role in human carcinogenesis.
Sandra Eliasz +2 more
doaj +3 more sources
Characterization of doxycycline-dependent inducible Simian Virus 40 large T antigen immortalized human conjunctival epithelial cell line. [PDF]
PLoS ONE, 2019 PurposeTo present the properties of a newly developed immortalized human conjunctival epithelial cell (iHCjEC) line.MethodsiHCjECs were developed to induce Simian Virus 40 large T-antigen (SV40LT) by incorporating lentivirus in a tetracycline (Tet ...
Arisa Mitani +8 more
doaj +2 more sources
Establishment and characterization of transformed goat primary cells by expression of simian virus 40 large T antigen for orf virus propagations. [PDF]
PLoS ONE, 2019 Due to the limited host range of orf virus (ORFV), primary cells derived from its natural hosts, such as goats and sheep, are recommended for isolation and propagation of wild type ORFV.
Yumiko Yamada +4 more
doaj +2 more sources
Serological evidence of an early seroconversion to Simian virus 40 in healthy children and adolescents. [PDF]
PLoS ONE, 2013 At present Simian virus 40 (SV40) infection in humans appears to be transmitted independently from early contaminated vaccines. In order to test the spread of SV40 infection in children, an immunologic assay employing specific SV40 synthetic peptides ...
Angelo Taronna +16 more
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Minimal Genome, Maximal Effect: How Polyomavirus Genomes Are Capable of Complex Pathogenesis [PDF]
VirusesThe Polyomaviridae family contains members known for achieving high seroprevalence within their target species despite a limited genomic economy. Minimalism, by definition, allows for the clarification and streamlining of purpose via the removal of ...
Michaela Lano, Barry Milavetz
doaj +2 more sources
Interaction between Simian Virus 40 Major Capsid Protein VP1 and Cell Surface Ganglioside GM1 Triggers Vacuole Formation [PDF]
mBio, 2016 Simian virus 40 (SV40), a polyomavirus that has served as an important model to understand many aspects of biology, induces dramatic cytoplasmic vacuolization late during productive infection of monkey host cells.
Yong Luo +5 more
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Simian virus 40 and human cancer. [PDF]
Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace, 1998 Deoxyribonucleic acid (DNA) oncoviruses can induce neoplastic transformation by interfering with proliferative proteins. Simian virus 40 (SV40) has been shown to induce brain tumors, osteosarcoma, lymphoid tumors and malignant mesothelioma in hamsters and SV40-like DNA sequences corresponding to the Rb-pocket binding domain of SV40 T-antigen (Tag) have
Mutti L. +3 more
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Specific Antibodies Reacting with SV40 Large T Antigen Mimotopes in Serum Samples of Healthy Subjects. [PDF]
PLoS ONE, 2016 Simian Virus 40, experimentally assayed in vitro in different animal and human cells and in vivo in rodents, was classified as a small DNA tumor virus.
Mauro Tognon +11 more
doaj +1 more source
Hepatology, EarlyView., 2022 Physiological activation of myeloid p38 controls macrophage IL‐12 production and crosstalk to the liver by modulating hepatic FGF21, and subsequently, brown adipose tissue thermogenesis during obesity Abstract Obesity features excessive fat accumulation in several body tissues and induces a state of chronic low‐grade inflammation that contributes to ...
María Crespo +14 more
wiley +1 more source
Interaction of Simian Virus 40 chromatin with Simian Virus 40 T-antigen [PDF]
Journal of Virology, 1977 We have studied the binding of the tumor antigen (T-antigen) of simian virus 40 to simian virus 40 chromatin (minichromosomes). The minichromosomes isolated from infected cells by a modification of standard techniques were relatively free of contaminating RNA and cellular DNA and had a ratio (by weight) of protein to DNA of approximately 1; their DNA ...
M, Persico-DiLauro +2 more
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