Results 21 to 30 of about 816,794 (268)

Lung adenocarcinoma originates from retrovirus infection of proliferating type 2 pneumocytes during pulmonary post-natal development or tissue repair [PDF]

, 2011
Jaagsiekte sheep retrovirus (JSRV) is a unique oncogenic virus with distinctive biological properties. JSRV is the only virus causing a naturally occurring lung cancer (ovine pulmonary adenocarcinoma, OPA) and possessing a major structural protein that ...
Palmarini, M., Ferri, N., Varasano Vincenzo, Murgia, C., Murgia C., Palmarini M., Vincenzo Varasano, Varasano, V., de las Heras Marcelo, Ceesay O., Marcelo de las Heras, Ferri Nicola, Caporale Marco, Di Francesco Gabriella, de las Heras M., Ceesay, O., Murgia Claudio, Palmarini Massimo, Nicola Ferri, Varasano V., de las Heras, M., Di Francesco G., Ousman Ceesay, Ferri N., Marco Caporale, Massimo Palmarini, Caporale M., Di Francesco, G., Gabriella Di Francesco, Claudio Murgia, Ceesay Ousman, Caporale, M.   +31 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

In-vitro demonstration of cell-mediated immunity to vaccinia virus in man [PDF]

, 1975
Cell mediated immunity to vaccinia virus in man was studied by lymphocyte transformation. Vaccinia antigen, propagated on BHK-21 and Vero cells, could be used successfully for in-vitro testing after partial purification as well as crude infectious ...
Koszinowski, Ulrich H., Thomssen, R., Volkmann, B.   +2 more
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Sialidase Activity in Transformed Cells

Journal of Biological Chemistry, 1973
Abstract Sialidase activity, ganglioside patterns, and total cellular sialic acid content were determined for normal and transformed hamster cells in tissue culture. Sialidase activity toward added extracellular disialo- and trisialoganglioside substrate was found in all transformed cell lines studied.
C L, Schengrund, R N, Lausch, A, Rosenberg   +2 more
openaire   +2 more sources

Stable nuclear transformation of Eudorina elegans

, 2013
Lerche K, Hallmann A. Stable nuclear transformation of Eudorina elegans. BMC Biotechnology. 2013;13(1): 11.UNLABELLED: ABSTRACT: BACKGROUND: A fundamental step in evolution was the transition from unicellular to differentiated, multicellular organisms ...
Lerche, Kai, Hallmann Armin, Hallmann, Armin ; https://orcid.org/, Lerche Kai, Armin Hallmann, Kai Lerche   +5 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Comparative Analysis of Nuclear Transfer Embryo Derived Mouse Embryonic Stem Cells. Part II: Gene regulation [PDF]

, 2012
In a mouse model nuclear transfer embryo-derived embryonic stem cell lines (ntESCs) of various genetic backgrounds and donor cell types were compared with reference ESCs and analyzed comprehensively at molecular level as a second part of a larger study ...
Julianna Kobolak, Geißler, S., Mamo, S., Horsch, Marion, Horsch, M., Andras Dinnyes, Geissler, Sandra, Mamo, Solomon, Marion Horsch, Kobolak, J., Beckers, Johannes, Solomon Mamo, Kobolak, Julianna, Dinnyes, Andras, Beckers, J., Johannes Beckers, Sandra Geißler, Dinnyes, A.   +17 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

FACS purification and transcriptome analysis of drosophila neural stem cells reveals a role for Klumpfuss in self-renewal [PDF]

, 2012
Drosophila neuroblasts (NBs) have emerged as a model for stem cell biology that is ideal for genetic analysis but is limited by the lack of cell-type-specific gene expression data.
Jonas Steinmann, Heinrich Reichert, Reichert, Heinrich, Maria Novatchkova, Burkard, Thomas R., Laurenson, Anne-Sophie, Anne-Sophie Laurenson, Knoblich, Juergen A., Steinmann, Jonas, van der Horst, Suzanne, Berger, Christian, Novatchkova, Maria, Christian Berger, Juergen A. Knoblich, Thomas R. Burkard, Heike Harzer, Suzanne van der Horst, Harzer, Heike   +17 more
core   +1 more source