Results 21 to 30 of about 6,825,361 (206)

Developmental toxicity of embryonic 1-naphthol exposure in zebrafish

Di-san junyi daxue xuebao, 2019
Objective To investigate the toxic effects of embryonic exposure to 1-naphthol (1-NAP) on zebrafish development and explore the possible mechanism. Methods Fertilized zebrafish eggs were exposed to 1-NAP at the concentrations of 40, 80, 160 and 200 μmol ...
REN Pingping, REN Pingping, SHU Liping, WANG Yihui, WANG Yihui   +4 more
doaj   +1 more source

Expression and cell transformation activity of dynactin‐associated protein isoforms

FEBS Open Bio, 2021
Overexpression of human dynactin‐associated protein isoform a (dynAPa) transforms NIH3T3 cells. DynAPa is a single‐pass transmembrane protein with a carboxy‐terminal region exposed to the outside of cells. According to the NCBI RefSeq database, there may
Xiaobo Yin, Shota Yamada, Hiroaki Kobayashi, Ryota Tanaka, Yuki Togo, Miho Hosoi, Mie Tsuchida, Tatsuki Kunoh, Shuichi Wada, Toshinobu Nakamura, Ryuzo Sasaki, Tamio Mizukami, Makoto Hasegawa   +12 more
doaj   +1 more source

Establishment of human embryonic stem cell WAe009-A-48 carrying a long QT syndrome mutation in SCN5A

Stem Cell Research, 2021
The long QT syndrome type 3 (LQT3) is currently the 3rd most prevalent of the 15 known types of LQT syndrome. Cardiac events in LQT3 are less frequent than LQT1 and LQT2, but more likely to be fatal.
Xiaofei Yang, Fujian Wu, Jiaqi Zhong, Furong Li   +3 more
doaj   +1 more source

A review of protocols for engineering human cardiac organoids

Heliyon, 2023
The use of human cardiac organoids (hCOs) as 3D in vitro models for cardiovascular research has shown great promise. Human pluripotent stem cells (hPSCs) have proven to be a potent source for engineering hCOs.
Fujian Wu, Qian He, Furong Li, Xiaofei Yang   +3 more
doaj   +1 more source

Role of H-Ras/ERK signaling in carbon nanotube-induced neoplastic-like transformation of human mesothelial cells

Frontiers in Physiology, 2014
Rapid development and deployment of engineered nanomaterials such as carbon nanotubes (CNTs) in various commercial and biomedical applications have raised concerns about their potential adverse health effects, especially their long-term effects which ...
Warangkana eLohcharoenkal, Liying eWang, Todd A Stueckle, Jino ePark, William eTse, Cerasela-Zoica eDinu, Yon eRojanasakul, Yon eRojanasakul   +7 more
doaj   +1 more source

In-vitro demonstration of cell-mediated immunity to vaccinia virus in man [PDF]

, 1975
Cell mediated immunity to vaccinia virus in man was studied by lymphocyte transformation. Vaccinia antigen, propagated on BHK-21 and Vero cells, could be used successfully for in-vitro testing after partial purification as well as crude infectious ...
Koszinowski, Ulrich H., Thomssen, R., Volkmann, B.   +2 more
core   +1 more source

Fusion Protein-Collagen Scaffolds: A New Potential Therapy for Thin Endometrium

Fertility & Reproduction
Background: Thin endometrium (TE), a leading cause of uterine factor infertility, remains a clinical challenge with limited therapeutic options. This study evaluates the effect of intrauterine perfusion with fusion protein-collagen scaffolds (FP-CS ...
Xi Yan, Pengnan Hu
doaj   +1 more source

Lung adenocarcinoma originates from retrovirus infection of proliferating type 2 pneumocytes during pulmonary post-natal development or tissue repair [PDF]

, 2011
Jaagsiekte sheep retrovirus (JSRV) is a unique oncogenic virus with distinctive biological properties. JSRV is the only virus causing a naturally occurring lung cancer (ovine pulmonary adenocarcinoma, OPA) and possessing a major structural protein that ...
Palmarini, M., Ferri, N., Varasano Vincenzo, Murgia, C., Murgia C., Palmarini M., Vincenzo Varasano, Varasano, V., de las Heras Marcelo, Ceesay O., Marcelo de las Heras, Ferri Nicola, Caporale Marco, Di Francesco Gabriella, de las Heras M., Ceesay, O., Murgia Claudio, Palmarini Massimo, Nicola Ferri, Varasano V., de las Heras, M., Di Francesco G., Ousman Ceesay, Ferri N., Marco Caporale, Massimo Palmarini, Caporale M., Di Francesco, G., Gabriella Di Francesco, Claudio Murgia, Ceesay Ousman, Caporale, M.   +31 more
core   +1 more source

Establishment of human embryonic stem cell WAe009-A-74 carrying a Long QT syndrome mutation in KCNH2

Stem Cell Research, 2022
Long-QT syndrome type 2 (LQT2) is a common malignant hereditary arrhythmia. Due to the lack of suitable animal and human models, the pathogenesis of LQT2 caused by human ether-a-go-go-related gene (hERG) deficiency is still unclear.
Lixiang Sun, Jiaqi Zhong, Fujian Wu, Furong Li, Xiaofei Yang, Zhiyu Zeng   +5 more
doaj   +1 more source

PIM1-dependent phosphorylation of Histone H3 at Serine 10 is required for MYC-dependent transcriptional activation and oncogenic transformation. [PDF]

, 2007
The serine/threonine kinase PIM1, cooperates with MYC in cell cycle progression and tumorigenesis. However, the nature of this cooperation remains elusive.
Salvatore Oliviero, Serafini, Riccardo, Riccardo Serafini, Alessandra De Robertis, Alessio Zippo, De Robertis, Alessandra, Zippo, Alessio, Oliviero, Salvatore   +7 more
core   +1 more source