Results 301 to 310 of about 432,951 (336)

The Biology of Normal and Neoplastic Stem Cells in CML

Leukemia & Lymphoma, 1993
Chronic myeloid leukemia (CML) has long served as a prototype malignancy for basic as well as clinical studies aimed at developing curative cancer treatment protocols. Well established features of chronic phase CML are its origin in a pluripotent stem cell, a now well defined molecular genetic basis involving the creation of a BCR-ABL fusion gene and ...
C, Eaves, C, Udomsakdi, J, Cashman, M, Barnett, A, Eaves   +4 more
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Neoplastic Stem Cells in Cutaneous Lymphomas

Archives of Dermatology, 2004
Objective: To investigate the prognostic value of initial characteristics including blood eosinophilia in patients with primary cutaneous T-cell lymphoma. Design: A retrospective inception cohort, patients included from date of diagnosis (1982-1998). Setting: Two dermatology departments of a university hospital.
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Clinical perspectives of concepts on neoplastic stem cells and stem cell-resistance in chronic myeloid leukemia

Leukemia & Lymphoma, 2008
In chronic myeloid leukemia (CML), neoplastic stem cells and/or their subclones exhibit resistance against BCR/ABL tyrosine kinase inhibitors (TKIs). Therefore, residual CML stem cells (subclones) in TKI-treated patients are a logical target of therapy, and their elimination is considered a major aim and clue in the development of curative treatment ...
Peter, Valent, Michael, Deininger
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Identification of a Neoplastic Stem Cell in Human Mast Cell Leukemia

Blood, 2014
Abstract Leukemic stem cells (LSCs) have recently been identified as an important target of therapy in various human leukemias and related blood cell disorders. Systemic mastocytosis (SM) is a rare hematologic neoplasm characterized by abnormal growth and accumulation of mast cells (MCs) in various organ systems, including the bone ...
Gregor Eisenwort, Barbara Peter, Katharina Blatt, Sabine Cerny-Reiterer, Gregor Hoermann, Irina Sadovnik, Martin Bilban, Thomas Rülicke, Michael Willmann, Juliana Schwaab, Andreas Reiter, Wolfgang R Sperr, Christine Mannhalter, Peter Valent   +13 more
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Abstract SY08-02: Normal and neoplastic stem cells

Cancer Research, 2016
Abstract The transition from single cell species to multicellular organisms led to organ and tissue development. The development and maintenance of organs/tissues in multicellular organisms has resulted in the emergence of specialized cells that self-renew as well as differentiate; these rare cells are stem cells.
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Characterization of human embryonic stem cells with features of neoplastic progression

Nature Biotechnology, 2009
Cultured human embryonic stem (hES) cells can acquire genetic and epigenetic changes that make them vulnerable to transformation. As hES cells with cancer-cell characteristics share properties with normal hES cells, such as self-renewal, teratoma formation and the expression of pluripotency markers, they may be misconstrued as superior hES cells with ...
Werbowetski-Ogilvie, Tamara, Bossé, Marc, Stewart, Morag H, Schnerch, Angelique, Ramos-Mejía, Verónica, Rouleau, Anne, Wynder, Tracy, Smith, Mary-Jo, Dinwall, Steve, Carter, Tim, Williams, Christopher, Harris, Charles, Dolling, Joanna, Wynder, Christopher, Boreham, Doug, Bhatia, Mickie   +15 more
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Cancer, Stem Cells and the Neoplastic Niche

2009
Conventionally, cancer is treated as a homogenous mass of highly proliferative cells, with therapeutics designed to destroy rapidly dividing cells. However, not only are cancers heterogeneous, but also small subsets are endowed with the ability to initiate cancer formation and metastasis.
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A microRNA signature differentiates between giant cell tumor derived neoplastic stromal cells and mesenchymal stem cells

Cancer Letters, 2012
Giant cell tumor (GCT) derived stromal cells (GCTSCs) have been identified as the neoplastic cell population of GCTs. Within these stromal cells a subpopulation has been identified that shares several features with mesenchymal stem cells (MSCs) indicating that these neoplastic cells develop from MSCs.
Joerg, Fellenberg, Heiner, Saehr, Burkhard, Lehner, Daniela, Depeweg   +3 more
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Stem Cells, Nonproliferating Cells, and Their Kinetics in Normal and Neoplastic Tissues

1977
At this time of increased efforts and promising results in the therapy of malignant neoplasias, it seems appropriate to review critically some principal aspects of Cell. and tissue kinetics as they relate to stem cells, to nonproliferating cells, and to Cell. recruitment into the mitotic cycle.
Milan Potmesil, Joseph LoBue, Anna Goldfeder   +2 more
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Onconephrology: The intersections between the kidney and cancer

Ca-A Cancer Journal for Clinicians, 2021
, Kenar D Jhaveri, Mark A Perazella
exaly