Results 231 to 240 of about 34,809 (291)

The Association Between the Retinal Sequelae of Myopia and Glaucoma in a Global Cohort. [PDF]

Clin Ophthalmol
Arnal LI, Mesfin Y, Ferreira G, Salvi A, Wai KM, Koo E, Kossler AL, Koo E, Rahimy E, Mruthyunjaya P, Ludwig CA.   +10 more
europepmc   +1 more source

Vascular Endothelial Growth Factors in Eye Diseases. Pathophysiology and New Therapeutic Strategies for Retinal and Choroideal Angiogenesis (Verisuonikasvutekijöiden merkitys silmäsairauksissa. Patofysiologiaa ja uusia hoitomenetelmiä verkkokalvon ja suonikalvon angiogeneettisiin sairauksiin) [PDF]

Kinnunen, Kati
core  

Targeting GRP78 and the Proteostasis Network to Break the Therapeutic Ceiling in Neuroendocrine Prostate Cancer

iNew Medicine, EarlyView.
ABSTRACT HSPA5 (also known as GRP78/BiP) is a master regulator of the endoplasmic reticulum (ER) stress response and a key node in the proteostasis network. In neuroendocrine prostate cancer (NEPC), an aggressive, therapy‐refractory lineage that emerges under pressure from androgen receptor (AR) directed therapies, GRP78 is upregulated and co‐opted to ...
Amos Olalekan Akinyemi, Md Rakibul Alam, Mithu Howlader, Mohammad Esfini Farahani, Lixiang Gu, Chun Li, Chripus Ngule, Kevin Fulp, Bolaji Owoyemi, Xinyi Wang, Samuel Nwadialo, Fatemeh Selani, Makumba Esoe, Obaleye Oluwafunminiyi, Zhiguo Li   +14 more
wiley   +1 more source

Predicting intravitreal treatment response using ultrawide-field angiographic biomarkers in diabetic retinopathy. [PDF]

Adv Ophthalmol Pract Res
Reddy K, Deng C, Purt B, Liang Y, Bommakanti N, Yu G, Rosenthal J, Paulus YM.   +7 more
europepmc   +1 more source

Sequential ultrasound‐driven dynamic control of macrophage polarization combined with hydrogel for mechano‐chemical synergistic tissue repair

Interdisciplinary Medicine, EarlyView.
This study presents an innovative therapeutic strategy that integrates sequential ultrasound therapy with an injectable oxidized dextran‐metformin (ODE‐Met) hydrogel to dynamically regulate macrophage polarization and promote angiogenesis for inflamed tissue repair.
Fulong Man, Kun Wang, Zichen Yang, Lulu An, Caoyi You, Rongjie Li, Yanni Cai, Yang Li, Li Chen, Yiqiong Liu, Yan Li, Haiqing Dong, Yongyong Li   +12 more
wiley   +1 more source

A narrative review of pathologic response in non-small cell lung cancer: challenges, implications, and future directions. [PDF]

Transl Lung Cancer Res
Li Y, Liang F, Xiao S, Yuan C, Chen H.
europepmc   +1 more source

Non‐invasive and efficient diabetic retinal mitochondrial repair nanoplatform based on engineered endothelial mitochondrial‐derived vesicles with dynamic integrated stress response modulation

Interdisciplinary Medicine, EarlyView.
Under hyperglycemic conditions, mitochondrial dysfunction in retinal endothelial cells triggers excessive reactive oxygen species/reactive nitrogen species production, barrier protein degradation, and endothelial barrier breakdown in diabetic retinopathy.
Siyu Gui, Jie Gao, Tianchang Tao, Peng Wang, Zhihao Huang, Yuyang She, Jiajie Li, Jingwan Su, Zhe Lu, Jianchao Qiao, Song Wang, Xiaodong Sun, Mohan Li   +12 more
wiley   +1 more source

Targeting ATF6 reduces pathological neovascularization and improves visual outcomes in retinal disease models. [PDF]

Sci Rep
Bradley A, Park S, Park S, Kim K, Galdamez A, Min H, Diaz-Aguilar MS, Hartnett ME, Lee EJ, Lin JH.   +9 more
europepmc   +1 more source

Freeze‐resistant, conductive semi‐interpenetrating network hydrogels enable oxidative stress regulation and enhanced wound healing

Interdisciplinary Medicine, EarlyView.
A multifunctional SFMA9/PF1 semi‐interpenetrating hydrogel with excellent conductivity, antioxidant activity, and freeze resistance effectively regulates the wound microenvironment, reduces oxidative stress and inflammation, promotes angiogenesis, and accelerates full‐thickness skin regeneration.
Xiaomin Sun, Yanqin Yu, Xinyuan He, Kaiyi Tang, Lijing Teng, Tianbao Qian, Zhu Zeng, Zuquan Hu   +7 more
wiley   +1 more source