Results 121 to 130 of about 78,503 (261)

PARP Inhibitors in Genitourinary Cancer: A New Paradigm Beyond Prostate Cancer

open access: yesInternational Journal of Urology, EarlyView.
ABSTRACT Alterations in the homologous recombination repair genes, such as BRCA1 and BRCA2, are prevalent in various cancers, presenting a unique opportunity to develop synthetic lethal strategies that target homologous recombination deficiency (HRD).
Yohei Okuda   +8 more
wiley   +1 more source

Surgical Outcomes of the Non‐renorrhaphy Technique During Robot‐Assisted Partial Nephrectomy for Highly Complex Renal Tumors (RENAL Score ≥ 10)

open access: yesInternational Journal of Urology, EarlyView.
ABSTRACT Objectives Non‐renorrhaphy technique during partial nephrectomy has not been sufficiently studied. This study aimed to evaluate the surgical outcomes of the non‐renorrhaphy technique in robot‐assisted partial nephrectomy (RAPN) for tumors with RENAL scores of 10–12. Methods We retrospectively analyzed 51 consecutive patients who underwent RAPN
Kosuke Hamada   +8 more
wiley   +1 more source

Perirenal Fat in Disease Progression: From Inflammatory Mediator to Therapeutic Target

open access: yesInternational Journal of Urology, EarlyView.
ABSTRACT Perirenal fat (PRF), the adipose tissue that encases the kidneys, has long been considered a passive energy reservoir and mechanical buffer. However, emerging evidence has identified PRF as a biologically active visceral fat depot that secretes adipocytokines, inflammatory mediators, and other bioactive molecules, and thereby contributes to ...
Eiji Kashiwagi
wiley   +1 more source

Renal Arteriovenous Fistula Following Nephrectomy

open access: green, 1956
William H. Muller, Willard E. Goodwin
openalex   +2 more sources

Impact of Impaired Renal Function on the Efficacy and Safety of Second‐Line Tyrosine Kinase Inhibitor Therapy After First‐Line Immuno‐Oncology Combination Therapy in Metastatic Renal Cell Carcinoma: A Japanese Multicenter Retrospective Study

open access: yesInternational Journal of Urology, EarlyView.
ABSTRACT Objectives To evaluate the effects of renal impairment at the time of second‐line tyrosine kinase inhibitor (TKI) therapy initiation and rapid renal function decline during first‐line immuno‐oncology (IO) combination therapy on metastatic renal cell carcinoma (mRCC) patients treated with second‐line TKIs. Methods This multicenter retrospective
Naoki Fujita   +20 more
wiley   +1 more source

NEPHRECTOMY

open access: green, 1912
ARPAD G. GERSTER
openalex   +2 more sources

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