Results 41 to 50 of about 137,320 (331)

Clinical significance of serum neutrophil gelatinase-associated lipocalin in the early diagnosis of renal function deterioration after radical nephrectomy [PDF]

Kosin Medical Journal, 2018
ObjectivesThe standard metrics used to monitor the progression of acute kidney injury (AKI) include markers such as serum creatinine, blood urea nitrogen, and estimated glomerular filtration rate (eGFR).
Taek Sang Kim, Su Hwan Kang, Pil Moon Kang, Hongkoo Ha, Su Dong Kim, Jangho Yoon, Hyunyong Hwang   +6 more
doaj   +1 more source

PBRM1 Deficiency Reshapes an Immune Suppressive Microenvironment Through Epigenetic Tuning of PBRM1‐KDM5C‐IL6 Axis in ccRCC

Advanced Science, EarlyView.
PBRM1 ranks as the second most commonly mutated gene in ccRCC. This study reveals that PBRM1 loss promotes an immunosuppressive microenvironment by elevating M2 TAMs via the KDM5C–IL‐6 axis. These M2 TAMs, along with CAFs, form a barrier that excludes CD8+ T cells. Targeting IL‐6 synergizes with anti‐PD1 therapy, offering a promising strategy for PBRM1‐
Wenjiao Xia, Hongru Wang, Yu Dong, Zitong Yang, Yiyang Zhou, Zhinan Xia, Qinchen Li, Liangliang Ren, Yichun Zheng, Junliang Yan, Dongmei Ma, Zhi Chen, Xingang Cui, Guixin Zhu, Cheng Zhang   +14 more
wiley   +1 more source

Circular RNAs in Clear Cell Renal Cell Carcinoma: Their Microarray-Based Identification, Analytical Validation, and Potential Use in a Clinico-Genomic Model to Improve Prognostic Accuracy [PDF]

, 2019
Circular RNAs (circRNAs) may act as novel cancer biomarkers. However, a genome-wide evaluation of circRNAs in clear cell renal cell carcinoma (ccRCC) has yet to be conducted. Therefore, the objective of this study was to identify and validate circRNAs in
Erbersdobler, Andreas, Fendler, Annika, Franz, Antonia, Jung, Klaus, Jung, Monika, Kilic, Ergin, Ralla, Bernhard, Rochow, Hannah, Stephan, Carsten, Weickmann, Sabine   +9 more
core   +2 more sources

Contribution of Gli1+ Adventitial Stem Cells to Smooth Muscle Cells in Atherosclerosis and Vascular Injury

Advanced Science, EarlyView.
Gli1+ adventitial stem cells (ASCs) have been thought to generate smooth muscle cells (SMCs) in atherosclerosis. Using a dual‐recombinase lineage tracing to exclude ectopic labeling, Wang et al. found that Gli1+ ASCs do not contribute to SMCs in atherosclerotic plaques.
Haixiao Wang, Xiuzhen Huang, Jialing Mou, Enci Wang, Yan Li, Wenjuan Pu, Yao Xie, Xiaoling Guo, Lixin Wang, Maoping Chu, Bin Zhou, Chao Niu   +11 more
wiley   +1 more source

An Interesting Case of Isolated Renal Stab Injury [PDF]

International Journal of Anatomy Radiology and Surgery, 2016
Isolated renal penetrating injury requiring exploration is rare. Kidney is retroperitoneal organ with strong muscular and rib cage support. Added to this Gerota’s fascia prevent direct injury to renal parenchyma. Here we have presented an interesting
Vinayak Gorakhnath Wagaskar, Vidyasagar Hansraj Baheti, Ajaykumar R Gajengi, Sujata Kiran Patwardhan   +3 more
doaj   +1 more source

A Retrospective, Multicenter, Long-Term Follow-Up Analysis of the Prognostic Characteristics of Recurring Non-Metastatic Renal Cell Carcinoma After Partial or Radical Nephrectomy

Frontiers in Oncology, 2021
This study aimed to compare the cancer-specific survival (CSS) and overall survival (OS) of nephrectomized patients with non-metastatic renal cell carcinoma (nmRCC) and local recurrence without distant metastasis (LR group), those with metastasis without
Sung Han Kim, Boram Park, Eu Chang Hwang, Sung-Hoo Hong, Chang Wook Jeong, Cheol Kwak, Seok Soo Byun, Jinsoo Chung   +7 more
doaj   +1 more source

Operative and nonoperative management for renal trauma. Comparison of outcomes. A systematic review and meta-analysis [PDF]

, 2017
INTRODUCTION: Preservation of kidney and renal function is the goal of nonoperative management (NOM) of renal trauma (RT). The advantages of NOM for minor blunt RT have already been clearly described, but its value for major blunt and penetrating RT is ...
Brachini, Gioia, Cirillo, Bruno, LA TORRE, Marco, Migliori, Emanuele, Mingoli, Andrea, Sapienza, Paolo, Zambon, Martina   +6 more
core   +1 more source

SETDB2 Mitigates Podocyte Dysfunction in Diabetic Kidney Disease Through Epigenetic Silencing of SMAD3

Advanced Science, EarlyView.
SETDB2 epigenetically represses Smad3 transcription by increasing H3K9me3 enrichment at its promoter, thereby mitigating podocyte dysfunction in DKD. The transcription factor TCF21 binds directly to the Setdb2 promoter and enhances its expression in podocytes. Abstract Podocyte dysfunction represents both an early pathological hallmark and a key driver
Lanfang Li, Shimin Jiang, Qi Jin, Peng Qu, Yingjie Guo, Xushan Lan, Xinyu Li, Cuiting Sun, Sinan Ai, Xin Li, Weiliang Sun, Jing Guo, Wenge Li, Liang Peng, Lihong Liu   +14 more
wiley   +1 more source

Pseudoaneurysm after partial nephrectomy managed by selective angiographic embolization – a case report

Angiologia e Cirurgia Vascular
INTRODUCTION: Partial nephrectomy is considered the gold standard treatment for many renal tumors when technically feasible. Renal artery pseudoaneurysm and arteriovenous fistulas are rare life-threatening complications that occur more frequently after ...
Roberto Cunha, Manuel Silva, Pedro Sousa, Mafalda Correia, Isabel Vieira, Isabel Cássio, Nelson Oliveira, Emanuel Dias   +7 more
doaj   +1 more source

EXPERIENCE OF LAPAROSCOPIC SURGERY IN THE TREATMENT OF RENAL CELL CANCER ON THE BASIS OF THE REPUBLICAN CLINICAL ONCOLOGICAL DISPENSARY

Креативная хирургия и онкология, 2017
Purpose of the study. Study of the nearest results of laparoscopic operations in patients with localized renal cell carcinoma.Materials and methods. The results of treatment of 92 patients who underwent operative treatment in the period from 2015 to 2017
Yuriy N. Khrizman, Kamil S. Gantsev, Ruslan I. Safiullin, Andrey A. Khmelevskiy, Valeriy K. Shakurov, Raushan I. Aglyamov   +5 more
doaj   +1 more source