Results 51 to 60 of about 86,281 (261)

ANGPTL4 Exacerbates Renal Injury in Diabetic Kidney Disease by Impairing Podocyte Lipophagy via Compromised Lysosomal Degradative Function

Advanced Science, EarlyView.
In diabetic kidney disease, elevated podocyte ANGPTL4 is linked to reduced TFEB nuclear localization and compromised lysosomal degradative function. These changes impair podocyte lipophagy and promote lipid‐droplet accumulation and podocyte injury, which may contribute to renal injury progression.
Xiaojing Liu, Shimin Jiang, Zhenkun Yang, Shunlai Shang, Jiayi Li, Guming Zou, Cheng Zhou, Wenge Li   +7 more
wiley   +1 more source

Urinary biomarkers after donor nephrectomy [PDF]

, 2015
Contains fulltext : 154387.pdf (Publisher’s version ) (Open Access)As the beginning of living-donor kidney transplantation, physicians have expressed concern about the possibility that unilateral nephrectomy can be harmful to a healthy ...
Wever, K.E., Kloke, H.J., Hoogendijk-van den Akker, J.M., Zuilen, A.D. van, Warle, M.C., Akker, J.M. van den, Wetzels, J.F., Ozdemir, D.M., D'Ancona, F.C., Hoitsma, A.J.   +9 more
core   +3 more sources

TECHNIQUE OF NEPHRECTOMY [PDF]

Annals of Surgery, 1908
n ...
openaire   +2 more sources

Renal Tubular Epithelial CRLF1 Interacts With ITGB1 to Accelerate Fibrosis During the Transition From AKI to CKD

Advanced Science, EarlyView.
During renal fibrosis, SMAD3 acts as a transcription factor for CRLF1, promoting its expression and secretion. CRLF1 then binds to ITGB1 via an autocrine mechanism, activating the PI3K‐AKT signaling pathway to mediate renal fibrosis. This accelerates the progression from AKI to CKD, highlighting the therapeutic potential of targeting CRLF1 for ...
Chunjie Wang, Yan Zhang, Fang Bai, Shankui Qian, Feng Feng, Fangyi Lu, Jiahui Fan, Kuipeng Yu, Xiangdong Yang   +8 more
wiley   +1 more source

Histopathology Analysis, Clinical Profile, and Indications of Graft Nephrectomy: Single-center Study

Indian Journal of Transplantation
Background: Renal transplantation is the preferred form of treatment in patients with end-stage renal disease. Despite potent immunosuppression, the patient can develop graft failure in early and late posttransplant period due to immune and nonimmune ...
Pallav Gupta, Tarun Kumar, Vinant Bhargava, Manish Malik, Anurag Gupta, Vaibhav Tiwari, Ashwani Gupta, Anil Kumar Bhalla, Devinder Singh Rana   +8 more
doaj   +1 more source

USP30‐Mediated Deubiquitination of PEX5 Suppresses Pexophagy to Drive Tubular Injury in Diabetic Kidney Disease

Advanced Science, EarlyView.
USP30 accumulation in diabetic renal tubular epithelial cells deubiquitinates PEX5, suppresses pexophagy, and drives dysfunctional peroxisome accumulation and tubular injury. USP30 depletion restores PEX5 ubiquitination and pexophagy, improves peroxisomal function, and alleviates tubular damage, highlighting USP30 as a therapeutic target in diabetic ...
Jia Li, Chaoyang Hua, Guangpu Li, Furong Zhai, Jingjing Ren, Shaokang Pan, Qi Feng, Jianguo Wen, Dongwei Liu, Zhangsuo Liu, Jiayu Duan   +10 more
wiley   +1 more source

Deferred Cytoreductive Nephrectomy With Partial Hepatectomy for Giant Renal Cell Carcinoma of the Right Kidney With Extensive Hepatic Invasion: A Case Report in the Era of Systemic Immune Checkpoint Inhibitors and Tyrosine Kinase Inhibitors. [PDF]

IJU Case Rep
ABSTRACT Introduction Deferred cytoreductive nephrectomy may improve the prognosis of patients with metastatic renal cell carcinoma (RCC). However, reports of combined hepatic resection for RCC with liver invasion are limited, and treatment strategies remain insufficiently established.
Hiroshi Y, Inoue T, Minagawa T, Takahashi M, Katami A, Onozawa M, Shinoda M, Itano O, Miyazaki J.   +8 more
europepmc   +2 more sources

SPARC Drives Podocyte Mitochondrial Damage and Ferroptosis in Diabetic Kidney Disease Following Klotho Deficiency

Advanced Science, EarlyView.
Klotho deficiency promotes podocyte mitochondrial dysfunction and ferroptosis through activation of the PKCα/CUX1/SPARC/TGFβ‐RII axis. SPARC emerges as a key mediator linking Klotho loss to podocyte injury in DKD and other kidney injury models, suggesting broader implications for CKD progression.
Qing Yang, Huimin Jiang, Chenyang Xiong, Xindi Zhou, Qinqin Tan, Han Xiao, Lan Qiu, Chun Gan, Yaxi Chen, Haiping Yang, Wei Jiang, Qiu Li   +11 more
wiley   +1 more source

Synchronous Duodenal and Pancreatic Metastases From Clear Cell Renal Cell Carcinoma 18 Years After Nephrectomy: A Case Report. [PDF]

Clin Case Rep
ABSTRACT A 63‐year‐old man presented with melena and severe anemia 18 years after nephrectomy for clear cell renal cell carcinoma. Imaging and biopsy confirmed duodenal and pancreatic metastases mimicking pancreaticobiliary malignancy. He underwent pancreaticoduodenectomy.
Kulkarni A, Sapkota S, Vemula SSM, Motkur S, Jha A, Sharma RP, Rayamajhi S.   +6 more
europepmc   +2 more sources

Beneficial Body Mass Index for Age‐Related Kidney Function in Males and Females

AGING MEDICINE, EarlyView.
The impact of BMI on age‐related kidney function decline is highly sex‐ and age‐dependent. Normal BMI (18.5–25 kg/m2) is associated with better age‐related kidney function in all‐aged males and females older than 45 years. ABSTRACT Objectives Kidney function declines with aging, leading to a high prevalence of age‐related disease.
Lu Wei, Yao Ma, Xueqi Chen, Xinran Ni, Yu Zhang, Bei Zhu, Qun Zhang, Weihong Zhao   +7 more
wiley   +1 more source