Results 21 to 30 of about 173,599 (327)

Tubulointerstitial nephritis without glomerular crescent formation as an underestimated subgroup of renal involvement among microscopic polyangiitis patients: A case report

Clinical Case Reports, 2021
Although extra‐glomerular involvement of microscopic polyangiitis is not regarded as a characteristic finding of the disease, tubulointerstitial nephritis should be considered as a new subclass of renal involvement.
Se Hee Kim, Hae‐Rim Kim, Sang‐Heon Lee, Hong Ki Min   +3 more
doaj   +1 more source

Phase II Randomized Trial of Rituximab Plus Cyclophosphamide Followed by Belimumab for the Treatment of Lupus Nephritis

Arthritis & Rheumatology, 2020
To assess the safety, mechanism of action, and preliminary efficacy of rituximab followed by belimumab in the treatment of refractory lupus nephritis (LN).
Y. Atisha-Fregoso, S. Malkiel, Kristina M. Harris, M. Byron, L. Ding, S. Kanaparthi, William T. Barry, Wendy Gao, Kristin Ryker, Patti Tosta, A. Askanase, S. Boackle, W. Chatham, D. Kamen, David Karp, K. Kirou, S. Sam Lim, B. Marder, M. McMahon, Samir V. Parikh, W. Pendergraft, Amber S. Podoll, A. Saxena, D. Wofsy, B. Diamond, Dawn Smilek, C. Aranow, M. Dall'era   +27 more
semanticscholar   +1 more source

Freqüência de síndrome metabólica em pacientes com nefrite lúpica Frequency of metabolic syndrome in patients with lupus nephritis

Revista Brasileira de Reumatologia, 2008
INTRODUÇÃO: Os pacientes com lúpus eritematoso sistêmico (LES) apresentam morbimortalidade importante por doenças cardiovasculares (DCV). A síndrome metabólica (SM) é um transtorno complexo representado por um conjunto de fatores de risco para DCV ...
Bernardo Matos da Cunha, Evandro Mendes Klumb, Jaqueline Quintanilha Moura, Amanda Santos, Geraldo da Rocha Castelar Pinheiro, Elisa M. N. Albuquerque, Roger Abramino Levy   +6 more
doaj   +1 more source

A Patient with Henoch-Schönlein Purpura with Intussusception and intractable Nephritis [PDF]

Childhood Kidney Diseases, 2016
Henoch-Schönlein purpura (HSP) is the most common vasculitis in children, mainly affecting the small vessels of the skin, joints, gastrointestinal tract, and kidneys.
Min Kyoung Seo, Jeong Hong, Hyun Ee Yim, Ki Soo Pai   +3 more
doaj   +1 more source

Prognostic Impact of Genetic Variants of MECP2 and TIRAP on Clinical Outcomes of Systemic Lupus Erythematosus with and without Nephritis

Biomolecules, 2021
Systemic lupus erythematosus (SLE) is a chronic autoimmune illness with a growing prevalence in many populations. Few studies have examined genetic predisposition to SLE, so we aimed to examine the clinical impact of the genetic polymorphisms MECP2 ...
Safaa I. Tayel, Nashwa M. Muharram, Dina S. Fotoh, Hany S. Elbarbary, Huda I. Abd-Elhafiz, Eman A. El-Masry, Ahmed E. Taha, Shimaa E. Soliman   +7 more
doaj   +1 more source

Macrophage metabolic reprogramming presents a therapeutic target in lupus nephritis

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance IgG antibodies are a key component of adaptive humoral immunity but can cause organ damage if they bind self-antigen, as occurs in the autoimmune disease systemic lupus erythematosus (SLE).
Chenzhi Jing, Tomas Castro-Dopico, N. Richoz, Z. Tuong, J. Ferdinand, Laurence S. C. Lok, K. Loudon, G. Banham, R. Mathews, Zaeem Cader, Susan F. Fitzpatrick, Kathleen R. Bashant, M. Kaplan, A. Kaser, R. Johnson, M. Murphy, R. Siegel, M. Clatworthy   +17 more
semanticscholar   +1 more source

Molecular mechanisms governing the progression of nephritis in lupus prone mice and human lupus patients

Frontiers in Immunology, 2023
IntroductionPathologic inflammation is a major driver of kidney damage in lupus nephritis (LN), but the immune mechanisms of disease progression and risk factors for end organ damage are poorly understood.MethodsTo characterize molecular profiles through
Andrea R. Daamen, Hongyang Wang, Hongyang Wang, Prathyusha Bachali, Nan Shen, Kathryn M. Kingsmore, Robert D. Robl, Amrie C. Grammer, Shu Man Fu, Shu Man Fu, Peter E. Lipsky   +10 more
doaj   +1 more source

Experience of Using Activated Protein C in a Patient With Emphysematous Pyelonephritis Receiving Percutaneous Nephrostomy Drainage

International Journal of Gerontology, 2010
Drotrecogin alfa, a type of recombinant human activated protein C, has potential to reduce the mortality in severe sepsis, but may simultaneously increase the risk of serious bleeding events.
Yueh-Hung Lin, Shou-Chuan Shih, Chien-Liang Wu, Yi-Chou Chen, Yu-Wei Chen, Shih-Yi Lee   +5 more
doaj   +1 more source

Loss of interleukin-1 beta is not protective in the lupus-prone NZM2328 mouse model

Frontiers in Immunology, 2023
Aberrant activation of the innate immune system is a known driver of lupus pathogenesis. Inhibition of the inflammasome and its downstream signaling components in murine models of lupus has been shown to reduce the severity of disease. Interleukin-1 beta
Shannon N. Loftus, Shannon N. Loftus, Jianhua Liu, Celine C. Berthier, Johann E. Gudjonsson, Mehrnaz Gharaee-Kermani, Mehrnaz Gharaee-Kermani, Lam C. Tsoi, Lam C. Tsoi, Lam C. Tsoi, J. Michelle Kahlenberg, J. Michelle Kahlenberg   +11 more
doaj   +1 more source

Immunoglobulin a vasculitis after a not so innocuous wasp bite

Indian Pediatrics Case Reports, 2022
Background: Immunoglobulin A vasculitis (IgAV), previously known as Henoch–Schonlein purpura (HSP), is the most common vasculitis in children. Previous studies have identified various triggers of IgAV, with infections being the most common.
Aditi Sharma, Vikram Singh, Suprita Kalra   +2 more
doaj   +1 more source