Results 21 to 30 of about 100,574 (164)

Kidney biopsy in patients with small kidneys: diagnostic yield and treatment modification in a retrospective cohort study

Renal Failure
Background Reduced renal size has traditionally been considered a relative contraindication to kidney biopsy because of the perception that advanced chronic damage provides limited diagnostic or therapeutic benefit.
Wen Wang, Xing Chen, Ruopei Wang, Lijing Yao, Lu Zhang   +4 more
doaj   +1 more source

The Association of Angiotension Converting Enzyme Gene Polimorphism with Prognosis of Henoch-Schönlein Purpura with Renal Involvement in the Children

Namık Kemal Tıp Dergisi, 2020
Aim:Henoch-Schönlein purpura (HSP) is a vasculitis rarely progresses to renal failure. The mechanism of renal failure in HSP has been associated with increased angiotensin converting enzyme (ACE) activity and increased local angiotension-II concentration
Sevliya ÖCAL DEMİR, Müferet ERGÜVEN
doaj   +1 more source

Loss of interleukin-1 beta is not protective in the lupus-prone NZM2328 mouse model

Frontiers in Immunology, 2023
Aberrant activation of the innate immune system is a known driver of lupus pathogenesis. Inhibition of the inflammasome and its downstream signaling components in murine models of lupus has been shown to reduce the severity of disease. Interleukin-1 beta
Shannon N. Loftus, Shannon N. Loftus, Jianhua Liu, Celine C. Berthier, Johann E. Gudjonsson, Mehrnaz Gharaee-Kermani, Mehrnaz Gharaee-Kermani, Lam C. Tsoi, Lam C. Tsoi, Lam C. Tsoi, J. Michelle Kahlenberg, J. Michelle Kahlenberg   +11 more
doaj   +1 more source

Lupus nephritis

Kidney International, 1997
Contains fulltext : 24337___.PDF (Publisher’s version ) (Open Access)
openaire   +3 more sources

Immunoglobulin a vasculitis after a not so innocuous wasp bite

Indian Pediatrics Case Reports, 2022
Background: Immunoglobulin A vasculitis (IgAV), previously known as Henoch–Schonlein purpura (HSP), is the most common vasculitis in children. Previous studies have identified various triggers of IgAV, with infections being the most common.
Aditi Sharma, Vikram Singh, Suprita Kalra   +2 more
doaj   +1 more source

Inflammatory Signatures and Biomarkers: The Renal-Vesical Axis in Alzheimer Progression [PDF]

International Neurourology Journal
Alzheimer disease (AD) has long been viewed as a disorder confined to the central nervous system. Accumulating evidence, however, indicates that systemic inflammation and peripheral organ dysfunction are closely linked to disease progression.
Yebeen Kim, Jaewoon Jung, Asifiwe Clarisse Cirunduzi, Seonghyun Yoon, Seokyoung Bang, Seung-Hoon Yang   +5 more
doaj   +1 more source

Novel clinical and genetic insights into Gitelman syndrome from 95 Chinese patients

Human Genomics
Background Gitelman syndrome (GS) is a rare tubulopathy with clinical and genetic heterogeneity. This study aimed to investigate the characteristics of Chinese GS patients. Methods The diagnosis of GS was established by combining clinical phenotypes with
Xiaomeng Shi, Lu Zhang, Xing Chen, Peijin Bai, Leping Shao   +4 more
doaj   +1 more source

Unveiling the immune landscape and microenvironmental architecture of IgA nephropathy using single‐cell imaging mass cytometry

Clinical & Translational Immunology
Objective The heterogeneity in the pathology of IgA nephropathy (IgAN) represents a significant gap in current research, emphasising the need for individualised treatment strategies.
Xing Chen, Long Liu, Lijing Yao, Jianxin Shen, Hengyuan Zhang, Leping Shao, Xingxing Yu, Zhijuan Lin, Lu Zhang   +8 more
doaj   +1 more source

Functional validation of spliceogenic COL4A3 and COL4A4 variants by minigene assays refines molecular diagnosis of Alport syndrome

Human Genomics
Background Alport syndrome (AS) is a hereditary progressive kidney disease caused by pathogenic variants in the COL4A3, COL4A4, and COL4A5 genes. Aberrant pre-mRNA splicing represents a major disease mechanism in AS, and both synonymous and intronic ...
Lina Wang, Zhi Wang, Yan Zhao, Xuyan Liu, Qiaomei Cui, Shuimi Zhang, Ran Zhang, Leping Shao   +7 more
doaj   +1 more source

A predictive model to explore risk factors for Henoch–Schönlein purpura nephritis in children: a retrospective cross-sectional study

Frontiers in Public Health
ObjectiveThe risk factors for Henoch–Schönlein purpura nephritis (HSPN) remain largely unclear, particularly in family environment and vaccination.
Qianwen Yang, Qianwen Yang, Maoyang Zhang, Zilong Dong, Fang Deng   +4 more
doaj   +1 more source