Results 21 to 30 of about 158,092 (291)

Experience of Using Activated Protein C in a Patient With Emphysematous Pyelonephritis Receiving Percutaneous Nephrostomy Drainage

International Journal of Gerontology, 2010
Drotrecogin alfa, a type of recombinant human activated protein C, has potential to reduce the mortality in severe sepsis, but may simultaneously increase the risk of serious bleeding events.
Yueh-Hung Lin, Shou-Chuan Shih, Chien-Liang Wu, Yi-Chou Chen, Yu-Wei Chen, Shih-Yi Lee   +5 more
doaj   +1 more source

Differences in clinicopathologic variables between Borrelia C6 antigen seroreactive and Borrelia C6 seronegative glomerulopathy in dogs. [PDF]

, 2019
BackgroundRapidly progressive glomerulonephritis has been described in dogs that seroreact to Borrelia burgdorferi, but no studies have compared clinicopathologic differences in Lyme-seroreactive dogs with protein-losing nephropathy (PLN) versus dogs ...
Goldstein RE, Grauer GF, Kalish RA, Levy S, Levy SA, Rolla D, Scorpio DG   +6 more
core   +1 more source

Prophylactic inhibition of soluble epoxide hydrolase delays onset of nephritis and ameliorates kidney damage in NZB/W F1 mice [PDF]

, 2019
Epoxy-fatty-acids (EpFAs), cytochrome P450 dependent arachidonic acid derivatives, have been suggested to have anti-inflammatory properties, though their effects on autoimmune diseases like systemic lupus erythematosus (SLE) have yet to be investigated ...
Dragun, Duska, Enghard, Philipp, Gollasch, Maik, Hammock, Bruce D., Klocke, Jan, Riemekasten, Gabriela, Rudolph, Birgit, Schunck, Wolf-Hagen, Ulu, Arzu, Wu, Kaiyin   +9 more
core   +2 more sources

Prognostic Impact of Genetic Variants of MECP2 and TIRAP on Clinical Outcomes of Systemic Lupus Erythematosus with and without Nephritis

Biomolecules, 2021
Systemic lupus erythematosus (SLE) is a chronic autoimmune illness with a growing prevalence in many populations. Few studies have examined genetic predisposition to SLE, so we aimed to examine the clinical impact of the genetic polymorphisms MECP2 ...
Safaa I. Tayel, Nashwa M. Muharram, Dina S. Fotoh, Hany S. Elbarbary, Huda I. Abd-Elhafiz, Eman A. El-Masry, Ahmed E. Taha, Shimaa E. Soliman   +7 more
doaj   +1 more source

The involvement of T regulatory lymphocytes in a cohort of lupus nephritis patients: a pilot study [PDF]

, 2015
T regulator lymphocytes (Tregs) play a key role in the maintenance of immune tolerance and in the development of autoimmune diseases. Expression of Foxp3 is specific for Tregs, and can be used for the identification of these cells.
Afeltra, Antonella, Amoroso, Antonio, Barbano, Biagio, Cianci, Rosario, Gigante, Antonietta, Liberatori, Marta, Margiotta, Domenico Paolo Emanuele, ROSSI FANELLI, Filippo, Taffon, Chiara   +8 more
core   +1 more source

Molecular mechanisms governing the progression of nephritis in lupus prone mice and human lupus patients

Frontiers in Immunology, 2023
IntroductionPathologic inflammation is a major driver of kidney damage in lupus nephritis (LN), but the immune mechanisms of disease progression and risk factors for end organ damage are poorly understood.MethodsTo characterize molecular profiles through
Andrea R. Daamen, Hongyang Wang, Hongyang Wang, Prathyusha Bachali, Nan Shen, Kathryn M. Kingsmore, Robert D. Robl, Amrie C. Grammer, Shu Man Fu, Shu Man Fu, Peter E. Lipsky   +10 more
doaj   +1 more source

SERPINB3 delays glomerulonephritis and attenuates the lupus-like disease in lupus murine models by inducing a more tolerogenic immune phenotype [PDF]

, 2018
Objective: To explore the effects of SERPINB3 administration in murine lupus models with a focus on lupus-like nephritis. Methods: 40 NZB/W F1 mice were subdivided into 4 groups and intraperitoneally injected with recombinant SERPINB3 (7.5 \u3bcg/0.1 mL ...
Beggio, M, Biasiolo, A, Cappon, A, Cavicchioli, L, Codolo, G, Doria, A., Gatto, M, Ghirardello, A, Luisetto, R, Maggioni, G, Pontisso, P, Saccon, F, Venturini, R   +12 more
core   +2 more sources

The Association of Angiotension Converting Enzyme Gene Polimorphism with Prognosis of Henoch-Schönlein Purpura with Renal Involvement in the Children

Namık Kemal Tıp Dergisi, 2020
Aim:Henoch-Schönlein purpura (HSP) is a vasculitis rarely progresses to renal failure. The mechanism of renal failure in HSP has been associated with increased angiotensin converting enzyme (ACE) activity and increased local angiotension-II concentration
Sevliya ÖCAL DEMİR, Müferet ERGÜVEN
doaj   +1 more source

Climate change and the kidney [PDF]

, 2019
The worldwide increase in temperature has resulted in a marked increase in heat waves (heat extremes) that carries a markedly increased risk for morbidity and mortality.
Butler-Dawson, Jaime, Diaz, Henry F., Garcia, Gabriela, Hernando, Ana Andres, Johnson, Richard J., Lanaspa, Miguel A., Lemery, Jay, Newman, Lee S., Rodriguez-Iturbe, Bernardo, Roncal-Jimenez, Carlos A., Sato, Yuka, Sánchez-Lozada, Laura G., Tolan, Dean R.   +12 more
core   +1 more source

Loss of interleukin-1 beta is not protective in the lupus-prone NZM2328 mouse model

Frontiers in Immunology, 2023
Aberrant activation of the innate immune system is a known driver of lupus pathogenesis. Inhibition of the inflammasome and its downstream signaling components in murine models of lupus has been shown to reduce the severity of disease. Interleukin-1 beta
Shannon N. Loftus, Shannon N. Loftus, Jianhua Liu, Celine C. Berthier, Johann E. Gudjonsson, Mehrnaz Gharaee-Kermani, Mehrnaz Gharaee-Kermani, Lam C. Tsoi, Lam C. Tsoi, Lam C. Tsoi, J. Michelle Kahlenberg, J. Michelle Kahlenberg   +11 more
doaj   +1 more source