Results 41 to 50 of about 16,522 (203)

Hypoxia/inflammation-induced upregulation of HIF-1α and C/EBPβ promotes nephroblastoma cell EMT by improving HOXA11-AS transcription

Heliyon
Background: Homeobox (HOX) A11 antisense RNA (HOXA11-AS) has been identified as a cancer promoting lncRNA and is overexpressed in nephroblastoma. However, how HOXA11-AS is regulated in a hypoxic inflammatory environment has not been studied.
Shibo Zhu, Rui Zhou, Xiangliang Tang, Wen Fu, Wei Jia   +4 more
doaj   +1 more source

Mapping the Knowledge Structure and Thematic Trends of Wilms Tumor: Insights From Text Mining

Organ Medicine, EarlyView.
This scientometric analysis of Wilms tumor research from 1945 to 2024 highlights United States research leadership, limited international collaboration, and emerging hotspots in biomarkers, nephron‐sparing surgery, and immunotherapy. ABSTRACT Background Wilms tumor (WT), also known as nephroblastoma, is one of the most common renal malignancies in ...
Boshen Shu, Shufeng Zhang, Jian Gao, Lin Wang, Xiaohui Wang   +4 more
wiley   +1 more source

DNA Methylation and Transcriptomic Profiles of Wilms Tumour Reveal New Deregulated Genes and Epigenetic Processes Relevant for Tumour Stratification and Management

International Journal of Cancer, Volume 159, Issue 11, Page 2736-2754, 1 December 2026.
ABSTRACT Wilms Tumour (WT), the most common kidney cancer in children, presents features of altered kidney development and frequently exhibits molecular alterations at the 11p15.5 imprinted locus, affecting the IGF2 and H19 genes, which contribute to tumour growth and predisposition.
Abu Saadat, Francesco Cecere, Federica Rossetti, Laura Pignata, Emilia D'Angelo, Carlo Giaccari, Gaetano Verde, Paola Quarello, Franca Fagioli, Josep Roma, Manel Esteller, Enrique de Álava, Flavia Cerrato, Andrea Riccio, Angela Sparago   +14 more
wiley   +1 more source

ZSTK474 targeting PIK3R3 inhibits the Wilms' tumor through G0 / G1 phase arrest.

PLoS ONE
PurposeWilms' tumor (WT), also known as nephroblastoma, is the predominant form of primary malignant renal cancer. The unfavorable prognoses linked to anaplastic nephroblastoma and recurrent nephroblastoma emphasize the crucial requirement for the ...
Maoxian Li, Jiayan Liu, Liming Jin, Tao Mi, Zhaoxia Zhang, Chenghao Zhanghuang, Mujie Li, Jinkui Wang, Xin Wu, Zhaoying Wang, Zhang Wang, Dawei He   +11 more
doaj   +1 more source

Nephrogenic Rests/Nephroblastomatosis in Patients With Unilateral Wilms Tumor Are Not Associated With an Increased Risk of Relapse: An Analysis of Patients Treated on the SIOP‐WT‐2001 Protocol in the SIOP‐UK‐CCLG and SIOP‐GPOH Studies (2001–2022)

Pediatric Blood &Cancer, Volume 73, Issue 10, October 2026.
ABSTRACT Introduction Nephrogenic rests (NRs) and nephroblastomatosis (NBM) are precursor lesions for development of Wilms tumor (WT). Their association with the risk of relapse has not been properly assessed, partly due to misunderstanding of their diagnostic criteria and terminology.
Gordan M. Vujanić, Rhoikos Furtwängler, Tanzina Chowdhury, Christian Vokuhl, Jenny Wegert, Norbert Graf   +5 more
wiley   +1 more source

Modern Diagnosis OF Nephroblastoma in Children

, 2023
Nephroblastoma is a highly Malignant embryonic tumor originating from developing kidney tissues. The disease is the most common Malignant neoplasm of the genitourinary tract in children.
S, M. R. (Matrasulov), A, N. D. (Nishanov), Kh, S. D. (Sobirova)   +2 more
core  

Case report: Severe, refractory hypoglycemia in a 9-year-old Brittany Spaniel with renal nephroblastoma

Frontiers in Veterinary Science, 2023
A 9-year-old female spayed Brittany Spaniel presented for weakness and stumbling, and was diagnosed with severe hypoglycemia. An insulin to glucose ratio was not consistent with insulinoma as a cause for hypoglycemia.
Paula Simons, Bridget Lyons, Adrienne Bentley, Elisa Mazzaferro, Lindsay Thalheim, Riccardo Finotello, Lorenzo Ressel   +6 more
doaj   +1 more source

Histone H3K18 Lactylation Promotes the Malignant Progression of Wilms Tumor via a PSRC1/AKT/HIF‐1α Positive Feedback Loop

Advanced Science, Volume 13, Issue 56, 9 October 2026.
In nephroblastoma, aberrant glycolysis drives lactate accumulation, which elevates histone H3K18 lactylation via p300. Lactylation of the PSRC1 promoter activates its transcription. PSRC1 competitively binds AKT, relieving PTEN‐mediated inhibition and triggering AKT/mTOR/HIF‐1α signaling.
Yanping Wang, Hongjie Gao, Bifei Zhang, Xuetian Li, Ding Li, Aihua Cao, Fengyin Sun   +6 more
wiley   +1 more source

Nephroblastoma in a Bovine Fetus [PDF]

Veterinary Pathology, 1972
The right kidney of a bovine fetus aborted at approximately 6 months gestation was 15x19x10 cm, weighed 1.47 kg, and was not lobulated. The cut surface was pale pink and spongy. A diagnosis of nephroblastoma was made on the basis of epitheliallined tubular structures and cysts in a connective tissue stroma.
C A, Kirkbride, E J, Bicknell
openaire   +2 more sources

Report on the 13th international workshop on the CCN family of genes and inaugural ARBIOCOM conference, Nice, France

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
Celebration of the 13th ICCNS meeting joint to the 1st ARBIOCOM Conference held on the site of Nice in December 2025. Abstract The 13th International Workshop on the CCN Family of Genes, held in Nice as part of the inaugural ARBIOCOM World Conference, brought together investigators with diverse research backgrounds, disciplines, and expertise. Building
Bernard Perbal, Ralf Weiskirchen, Annick Perbal, Brahim Chaqour   +3 more
wiley   +1 more source