Results 91 to 100 of about 1,031,173 (193)

Bypassing vasopressin receptor signaling pathways in nephrogenic diabetes insipidus

, 2008
Water reabsorption in the kidney represents a critical physiological event in the maintenance of body water homeostasis. This highly regulated process relies largely on vasopressin (VP) action and on the VP-sensitive water channel (AQP2) that is ...
Hasler, Udo, Bouley, Richard, Nunes-Hasler, Paula, Brown, Dennis, Lu, Hua A J   +4 more
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Nephrogenic diabetes insipidus associated with a new mutation in the AVPR2 gene

Ожирение и метаболизм
Diabetes insipidus (DI) is an orphan disease clinically characterized by profound thirst and the excretion of large volumes of dilute urine. Nephrogenic diabetes insipidus (NDI) is characterized by resistance to the action of antidiuretic hormone (ADH ...
Y. A. Aleynikova, M. S. Berlovich, E. A. Pigarova, L. K. Dzeranova, M. S. Pankratova   +4 more
doaj   +1 more source

History of Diabetes Insipidus [PDF]

, 2016
Under physiological conditions, fluid and electrolyte homoeostasis is maintained by the kidney adjusting urine volume and composition according to body needs. Diabetes Insipidus is a complex and heterogeneous clinical syndrome affecting water balance and
VALENTI, Giovanna, TAMMA, GRAZIA
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A low affinity vasopressin V₂-receptor in inherited nephrogenic diabetes insipidus

, 1992
Congenital nephrogenic diabetes insipidus (NDI) is an X-linked inherited disorder characterized by renal resistance to the antidiuretic hormonal action of vasopressin.
Luzius, H., Rascher, W., Moritz, A., Jans, D., Grünbaum, E., Fahrenholz, F.   +5 more
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Fluvastatin Increases AQP2 Urine Excretion in a Dyslipidemic Patient with Nephrogenic Diabetes Insipidus: An In Vivo and In Vitro Study

, 2014
Objective: Among the pleiotropic effects of statins, we have previously reported that fluvastatin increases the amount of plasma membrane-expressed AQP2 in renal collecting duct cells both in vitro and in vivo, independently of vasopressin.
PROCINO, Giuseppe, Barbieri C, Maiolo D, Gullo D., Milano S, Squatrito S, Carmosino M, SVELTO, Maria   +7 more
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Effects of YM087 and VPA985 on the T237M mutant receptor functionality in nephrogenic diabetes insipidus

Türk Biyokimya Dergisi
Mutations detected in the AVPR2 gene (arginine vasopressin type 2 receptor) are known to cause nephrogenic diabetes insipidus (NDI). Several pharmacological chaperones (PCs) target misfolded AVPR2 proteins and rescue them from the quality control system ...
Avcu Elif Merve, Erdem Tuncdemir Beril, Saglar Ozer Emel   +2 more
doaj   +1 more source

Central diabetes insipidus: pathophysiology, diagnosis, and modern approaches to the treatment of antidiuretic hormone deficiency

Лечащий Врач
Background. Polydipsia-polyuria syndrome is characterized by abnormally increased fluid intake by the patient, which often mimics the manifestations of central diabetes insipidus (syn. – antidiuretic hormone deficiency).
E. A. Pigarova, A. S. Savieva, L. K. Dzeranova   +2 more
doaj   +1 more source

Nephrogenic diabetes insipidus

Nephrogenic diabetes insipidus (NDI) is a relatively rare disorder in which the kidney is unresponsive to the water-retaining action of vasopressin. With early diagnosis and therapy, children with NDI develop without mental retardation and survive into ...
Sands, J. M.
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Severe lithium-induced nephrogenic diabetes insipidus: The diuresis paradox

South African Medical Journal
We report a case of profound nephrogenic diabetes insipidus (NDI) in which renal resistance to antidiuretic hormone results in dilute polyuria despite normal circulating concentrations.
G S Tatz, Marc Blockman, J A Dave, I L Ross   +3 more
doaj   +1 more source

Nephrogenic diabetes insipidus in a large family. [PDF]

, 2006
Hereditary nephrogenic diabetes insipidus is a rare disease. We describe here three brothers with this disease from a big family consisting of 10 siblings. The case is undoubtedly X-linked because the sufferers are only boys, one of them with a different
Jankauskienė, Augustina,, Kaltenis, Petras,   +1 more
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