Results 31 to 40 of about 23,590 (248)
Case reports in anesthesiology, 2022 During the recent COVID-19 pandemic, the rapidly progressive shortage of intravenous sedative drugs led numerous intensive care units to look for potential alternatives in patients requiring mechanical ventilation for severe acute respiratory distress ...
C. Dupuis +5 more
semanticscholar +1 more source
The FASEB Journal, 2022 Water homeostasis is tightly regulated by the kidneys via the process of urine concentration. During reduced water intake, the antidiuretic hormone arginine vasopressin (AVP) binds to the vasopressin receptor type II (V2R) in the kidney to enhance ...
Federica Petrillo +5 more
semanticscholar +1 more source
Journal of the American Society of Nephrology, 2021 Visual Abstract Significance Statement Water reabsorption along the collecting duct is dependent on the function of aquaporin 2 (AQP2). Currently, information on microRNA (miRNA)-mediated, post-transcriptional regulation of AQP2, which may influence ...
Federica Petrillo +16 more
semanticscholar +1 more source
Diabetes insipidus in mice with a mutation in aquaporin-2. [PDF]
PLoS Genetics, 2005 Congenital nephrogenic diabetes insipidus (NDI) is a disease characterized by failure of the kidney to concentrate urine in response to vasopressin. Human kindreds with nephrogenic diabetes insipidus have been found to harbor mutations in the vasopressin
David J Lloyd +3 more
doaj +2 more sources
Clinical and Experimental Nephrology, 2021 Congenital nephrogenic diabetes insipidus (NDI) is primarily caused by loss-of-function mutations in the vasopressin type 2 receptor (V2R). Renal unresponsiveness to the antidiuretic hormone vasopressin impairs aquaporin-2 (AQP2) water channel activity ...
Fumiaki Ando
semanticscholar +1 more source
Clinical Nephrology - Case Studies, 2021 Nephrogenic diabetes insipidus (DI) refers to the reduction in the ability of the kidney to concentrate urine, which can be caused by partial or complete resistance at the site of action of anti-diuretic hormone (ADH) in the collecting tubules ...
M. Sohail +2 more
semanticscholar +1 more source
An AMPK activator as a therapeutic option for congenital nephrogenic diabetes insipidus
JCI Insight, 2021 Nephrogenic diabetes insipidus (NDI) patients produce large amounts of dilute urine. NDI can be congenital, resulting from mutations in the type-2 vasopressin receptor (V2R), or acquired, resulting from medications such as lithium. There are no effective
J. Klein +6 more
semanticscholar +1 more source
Idiopathic partial central diabetes insipidus
Einstein (São Paulo), 2023 Diabetes insipidus is a rare disorder characterized by the inability to concentrate urine, which results in hypotonic urine and increased urinary volume.
Larissa Fabre, Viviane Calice da Silva
doaj +1 more source
Molecular Characterization of an Aquaporin−2 Mutation Causing Nephrogenic Diabetes Insipidus
Frontiers in Endocrinology, 2021 The aquaporin 2 (AQP2) plays a critical role in water reabsorption to maintain water homeostasis. AQP2 mutation leads to nephrogenic diabetes insipidus (NDI), characterized by polyuria, polydipsia, and hypernatremia.
Qian Li +10 more
semanticscholar +1 more source
Incidence, severity and prognosis associated with hypernatremia in dogs and cats. [PDF]
, 2015 BackgroundHypernatremia has been associated with substantial morbidity and death in human patients. The incidence and importance of hypernatremia in dogs and cats has not been determined.Hypothesis/objectivesTo describe the incidence of and prognosis ...
Epstein, SE, Hopper, K, Ueda, Y
core +2 more sources