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Puumala orthohantavirus: prevalence, biology, disease, animal models and recent advances in therapeutics development and structural biology [PDF]

Frontiers in Immunology
Puumala orthohantavirus (PUUV) is an emerging zoonotic virus that was first discovered in the Puumala region of Finland in the early 1980s and is the primary etiological agent of nephropathia epidemica (NE), a milder form of a life-threatening disease ...
Alina Tscherne, Pablo Guardado-Calvo, Jordan J. Clark, Jordan J. Clark, Robert Krause, Florian Krammer, Florian Krammer, Florian Krammer, Florian Krammer   +8 more
doaj   +2 more sources

Elevated Cerebrospinal Fluid Neopterin Concentration Is Associated with Disease Severity in Acute Puumala Hantavirus Infection

Clinical and Developmental Immunology, 2013
Nephropathia epidemica (NE) caused by Puumala hantavirus (PUUV) is the most common hemorrhagic fever with renal syndrome (HFRS) in Europe. The infection activates immunological mechanisms that contribute to the pathogenesis and characteristics of the ...
Timo Hautala, Terhi Partanen, Tarja Sironen, Saara-Mari Rajaniemi, Nina Hautala, Olli Vainio, Olli Vapalahti, Heikki Kauma, Antti Vaheri   +8 more
doaj   +2 more sources

Serum Markers Associated with Disease Severity in a Bosnian Hemorrhagic Fever with Renal Syndrome Cohort [PDF]

Viruses, 2022
Puumala orthohantavirus (PUUV) is endemic in Europe and can cause hemorrhagic fever with renal syndrome (nephropathia epidemica). Disease features include fever, thrombocytopenia, and acute kidney injury (AKI).
Danny Noack, Maja Travar, Visnja Mrdjen, Jolanda J. C. Voermans, David van de Vijver, Richard Molenkamp, Marion P. G. Koopmans, Marco Goeijenbier, Barry Rockx   +8 more
doaj   +2 more sources

Designing a Conserved Immunogenic Peptide Construct from the Nucleocapsid Protein of Puumala orthohantavirus [PDF]

Viruses
Puumala orthohantavirus (PUUV) is an emerging zoonotic virus endemic to Europe and Russia that causes nephropathia epidemica, a mild form of hemorrhagic fever with renal syndrome (HFRS).
Ayushi Sehgal, Diksha Sharma, Neha Kaushal, Yogita Gupta, Ekaterina Martynova, Emmanuel Kabwe, Sara Chandy, Albert Rizvanov, Svetlana Khaiboullina, Manoj Baranwal   +9 more
doaj   +2 more sources

Cluster of human Puumala orthohantavirus infections due to indoor exposure?—An interdisciplinary outbreak investigation

Zoonoses and Public Health, Volume 69, Issue 5, Page 579-586, August 2022., 2022
Abstract Puumala orthohantavirus (PUUV) is the most important hantavirus species in Europe, causing the majority of human hantavirus disease cases. In central and western Europe, the occurrence of human infections is mainly driven by bank vole population dynamics influenced by beech mast.
Christina Princk, Stephan Drewes, Kristin M. Meyer‐Schlinkmann, Marion Saathoff, Florian Binder, Jona Freise, Beate Tenner, Sabrina Weiss, Jörg Hofmann, Jutta Esser, Martin Runge, Jens Jacob, Rainer G. Ulrich, Johannes Dreesman   +13 more
wiley   +1 more source

Cerebrospinal fluid metabolomics: detection of neuroinflammation in human central nervous system disease

Clinical &Translational Immunology, Volume 10, Issue 8, 2021., 2021
In this review, we summarise the current human evidence of the use of cerebrospinal fluid metabolomics to detect neuroinflammation in acute and chronic neurological and psychiatric diseases. The review highlights the potential utility of metabolites involved in the tryptophan–kynurenine and nitric oxide pathway and neopterin as biomarkers for ...
Jingya Yan, Unnikrishnan Kuzhiumparambil, Sushil Bandodkar, Russell C Dale, Shanlin Fu   +4 more
wiley   +1 more source

Long-Term Consequences of Puumala Hantavirus Infection

Viruses, 2022
Several viral infections are associated with acute and long-term complications. During the past two years, there have been many reports on post-infectious symptoms of the patients suffering from COVID-19 disease.
Jukka Mustonen, Antti Vaheri, Ilkka Pörsti, Satu Mäkelä   +3 more
doaj   +1 more source

Central Nervous System and Ocular Manifestations in Puumala Hantavirus Infection

Viruses, 2021
Puumala hantavirus (PUUV), carried and spread by the bank vole (Myodes glareolus), causes a mild form of hemorrhagic fever with renal syndrome (HFRS) called nephropathia epidemica (NE).
Nina Hautala, Terhi Partanen, Anna-Maria Kubin, Heikki Kauma, Timo Hautala   +4 more
doaj   +1 more source

Coagulopathy in Acute Puumala Hantavirus Infection

Viruses, 2021
Puumala hantavirus (PUUV) causes a hemorrhagic fever with renal syndrome (HFRS), also called nephropathia epidemica (NE), which is mainly endemic in Europe and Russia.
Sirpa Koskela, Satu Mäkelä, Tomas Strandin, Antti Vaheri, Tuula Outinen, Lotta Joutsi-Korhonen, Ilkka Pörsti, Jukka Mustonen, Outi Laine   +8 more
doaj   +1 more source

Serological investigation of orthohantaviruses in patients with fever of unknown origin in Kazakhstan

Zoonoses and Public Health, Volume 67, Issue 3, Page 271-279, May 2020., 2020
Abstract Objective Orthohantaviruses are geographically widely distributed and present various clinical manifestations from mild symptoms to the severe form of haemorrhagic fever with renal syndrome (HFRS) in Eurasia. Official registration of HFRS in Kazakhstan started in the year 2000.
Nur Tukhanova, Anna Shin, Karlygash Abdiyeva, Nurkeldi Turebekov, Lyazzat Yeraliyeva, Ravilya Yegemberdiyeva, Zhanna Shapiyeva, Guenter Froeschl, Michael Hoelscher, Edith Wagner, Kerstin Rösel, Aliya Zhalmagambetova, Lyazzat Musralina, Stefan Frey, Sandra Essbauer   +14 more
wiley   +1 more source