Results 181 to 190 of about 121,280 (344)

Nephrotoxic drugs [PDF]

open access: yesDMW - Deutsche Medizinische Wochenschrift, 2005
D, Czock   +3 more
openaire   +2 more sources

Polydopamine‐Antibiotic Composite Coating for Antibiofilm Applications

open access: yesMacromolecular Bioscience, EarlyView.
Antibiotic‐loaded polydopamine coatings are developed to combat biofilm‐forming bacteria on catheter surfaces. These coatings strongly inhibit Pseudomonas aeruginosa biofilm formation on diverse materials, including during continuous artificial‐urine flow, and can accommodate multiple antibiotics.
Gillian A. Kropp   +6 more
wiley   +1 more source

Systematic Deciphering of ATBC Nephrotoxicity Mechanisms via Machine Learning and Single‐Cell Analysis

open access: yesMedicine Bulletin, EarlyView.
This study elucidates the nephrotoxic mechanism of acetyl tributyl citrate (ATBC) by integrating network toxicology, machine learning, and single‑cell multi‑omics analysis to systematically decipher the molecular mechanisms and cell‑type‑specific regulatory networks underlying ATBC‑induced kidney injury. First, a protein‑protein interaction network was
Yimao Wu   +5 more
wiley   +1 more source

Abietic Acid Enhances the Sedative Activity of Diazepam: In vivo Approach along with Receptor Binding Affinity and Molecular Interaction with the GABAergic System

open access: yesChemistryOpen, EarlyView.
Abietic acid (AA) reveals potent sedative potential by expressing fast sleeping onset and increased sleeping duration compare to the control group in thiopental sodium induced sleeping mice. The compound also exhibited notable binding affinity (–7.9 kcal/mol) toward GABAA receptors.
Meher Afroz   +10 more
wiley   +1 more source

Computational Study on Potentially Active Antibacterial Compounds in Secondary Metabolites of Extremophilic Microorganisms

open access: yesChemistryOpen, EarlyView.
This study employed density functional theory (DFT) and conceptual DFT (CDFT) to calculate the structures and properties of potential antibacterial compounds derived from 16‐membered lactone ring‐containing secondary metabolites of extremophiles, as well as midecamycin.
Dilong Li   +6 more
wiley   +1 more source

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