Results 191 to 200 of about 72,055 (308)

Environmental Mycotoxins and Brain Health: Protective Role of Bromelain Against Fumonisin B1 in SH‐SY5Y Cells

Environmental Toxicology, EarlyView.
ABSTRACT Fumonisin B1 (FB1), a mycotoxin commonly found in contaminated food and feed, has been increasingly implicated in neurotoxicity, although its mechanisms remain poorly understood. This study investigates the neurotoxic potential of FB1 in human SH‐SY5Y neuroblastoma cells, both undifferentiated and RA‐differentiated, and evaluates the ...
Gianluca Antonio Franco, Francesca Inferrera, Nicla Tranchida, Davide Di Paola, Roberta Fusco, Salvatore Cuzzocrea, Enrico Gugliandolo   +6 more
wiley   +1 more source

Dapagliflozin attenuates cisplatin-induced nephrotoxicity in rats through modulation of ROS/NF-κB, BCL2/Bax and PINK1/Parkin signaling pathways. [PDF]

Sci Rep
Khallaf EK, Ramadan EA, Elmazar MM, Safar MM.   +3 more
europepmc   +1 more source

Protective Effects of Bee Venom (Apis mellifera) Against Cadmium‐Induced Hepatorenal Toxicity, Oxidative Stress, and Anxiety‐Like Behavior in Rats

Environmental Toxicology, EarlyView.
ABSTRACT Cadmium (Cd) is a persistent environmental heavy metal and a major public health concern because it persists in the body for long periods and gradually accumulates in vital organs, particularly the liver, kidneys, and brain. Chronic Cd exposure promotes the excessive production of reactive oxygen species (ROS), which ultimately leads to ...
Soumaya Ghodbane, Chedli Ellijimi, Rym Elfessi, Ranya Hezzi, Khemaies Ben Rhouma, Hafedh Abdelmelek, Najet Srairi‐Abid, Mohsen Sakly, Riadh Marrouchi   +8 more
wiley   +1 more source

In vivo and molecular docking investigation of the novel anti-inflammatory and mitochondrial mechanisms underlying the renoprotective effects of resmetirom and curcumin in gentamicin-induced renal toxicity in rats. [PDF]

BMC Nephrol
Ahmed AS, Sabra MS, Shaltout ES, Abdelqader ZS.   +3 more
europepmc   +1 more source

Evidence-Based Assessment of Pesticide-Related Nephrotoxicity: Clinical Outcomes, Experimental Data, and Molecular Signatures. [PDF]

Int J Mol Sci
Lu HY, Chang Y, Chiang CK.
europepmc   +1 more source

Structural basis for a p21‐activated kinase 4 and nicotinamide phosphoribosyltransferase dual inhibitor

Acta Crystallographica Section D, EarlyView.
The 2‐aminopyridine moiety of KPT‐7523 binds p21‐activated kinase 4 and nicotinamide phosphoribosyltransferase, enabling a versatile design for multi‐target cancer therapy.Simultaneous inhibition of oncogenic signaling and metabolic pathways represents a promising approach for cancer therapy.
Jaehui Park, Hye Rim Hong, Sang Hyun Han, Jinsue Song, Se-Young Son, Saehae Choi, Sang Mi Park, Won-Kyu Lee, Chimari Jiko, Ji-Hun Kim, Jun-Goo Jee, Jeong Kyu Bang, Il Yeong Park, Soo Jae Lee   +13 more
wiley   +1 more source

Effectiveness of Amenamevir Vs. Valacyclovir in Preventing Herpes Zoster‐Related Hospitalization and Complications: A Target Trial Emulation Using a Large Japanese Claims Database

The Journal of Dermatology, EarlyView.
ABSTRACT Amenamevir is a novel anti‐herpes zoster drug that is increasingly used in Japan because of its once‐daily administration and lack of renal dose adjustment requirements. However, evidence of its clinical effectiveness is limited. This study aimed to estimate the clinical effectiveness of amenamevir vs. valacyclovir in preventing zoster‐related
Yasuhiro Kano, Yuya Kimura, Hideo Yasunaga   +2 more
wiley   +1 more source

<i>Maesa ramentacea</i> Leaf Extract Protects Against Gentamicin-Induced Nephrotoxicity in Wistar Rats by Modulating Renal Oxidative Stress, Inflammation and Apoptosis. [PDF]

Vet Med Int
Akter F, Sovon MSI, Hossain B, Islam MA, Das S, Biswas A, Uddin MS, Hasan MM.   +7 more
europepmc   +1 more source

A Systematic Review of Topical and Systemic Gentamicin for Wound Healing in Patients With Junctional and Dystrophic Epidermolysis Bullosa

Australasian Journal of Dermatology, EarlyView.
ABSTRACT Epidermolysis bullosa (EB) is an inherited mechanobullous genodermatosis caused by a mutation in genes encoding proteins integral to skin integrity. Premature termination codon readthrough therapies, such as gentamicin, have promise in facilitating full‐length protein expression in patients with EB.
Kelvin Truong, Joseph Joseph, Deborah Poh, Orli Wargon, Artiene Tatian   +4 more
wiley   +1 more source

Extraintestinal Manifestations of Inflammatory Bowel Disease: A Focus on Kidney Complications. [PDF]

Int J Mol Sci
Wu H, Lin A, Chi J, Zhang J, Peng B, Ni D, Hao H, Liu Z.   +7 more
europepmc   +1 more source