Results 11 to 20 of about 20,710 (242)
Neprilysin Inhibitors and Bradykinin [PDF]
Frontiers in Medicine, 2018 Bradykinin has important physiological actions related to the regulation of blood vessel tone and renal function, and protection from ischemia reperfusion injury.
Duncan J. Campbell +2 more
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Identification and bioinformatic analysis of neprilysin and neprilysin-like metalloendopeptidases in Drosophila melanogaster. [PDF]
microPublication biology, 2021 The neprilysin (M13) family of metalloendopeptidases comprises highly conserved ectoenzymes that cleave and thereby inactivate many physiologically relevant peptides in the extracellular space. Impaired neprilysin activity is associated with numerous human diseases.
Meyer, Heiko +5 more
openaire +5 more sources
Active site mutations change the cleavage specificity of neprilysin. [PDF]
PLoS ONE, 2012 Neprilysin (NEP), a member of the M13 subgroup of the zinc-dependent endopeptidase family is a membrane bound peptidase capable of cleaving a variety of physiological peptides.
Travis Sexton +4 more
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Neprilysin as a Biomarker: Challenges and Opportunities [PDF]
Cardiac Failure Review, 2020 Neprilysin (NEP) inhibition is a successful novel therapeutic approach in heart failure with reduced ejection fraction. Assessing individual NEP status might be important for gathering insights into mechanisms of disease and optimising individualised patient care.
Pavo, Noemi +4 more
openaire +5 more sources
IGF2BP1 Enhances Neprilysin mRNA Stability to Promote Proliferation, Invasion, and Angiogenesis in Placental Trophoblasts [PDF]
International Journal of General MedicineChengLing Fan,1,2 HongXia Zhou,2 YuFei Pan,3 Dan Lu1 1Medical College, Yangzhou University, Yangzhou, Jiangsu, 225009, People’s Republic of China; 2Department of Gynaecology and Obstetrics, Baoying Maternal and Child Health Hospital, Yangzhou, Jiangsu ...
Fan C, Zhou H, Pan Y, Lu D
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BMC Cardiovascular Disorders, 2020 Background Neprilysin has an essential role in regulating fluid balance and vascular resistance, and neprilysin inhibitors have shown beneficial effects in patients with heart failure.
Ik Jun Choi +7 more
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Combined drug sacubitril/valsartan -a new era of treatment of chronic heart failure
Медицинский совет, 2020 The article describes the possibility of using a new class of angiotensin II/neprilysin receptor inhibitor - sacubitrile/valsartan for the treatment of chronic heart failure (CHF). The role of the natriuretic peptide system in the pathogenesis of CHF and
V. S. Nikiforov
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Association between soluble neprilysin and diabetes: Findings from a prospective longitudinal study
Frontiers in Endocrinology, 2023 BackgroundThe potential role of neprilysin (NEP) in glucose metabolism has been found by basic studies but lacks population evidence. The objective of this study was to examine the association between serum NEP and diabetes in Chinese adults.MethodsIn a ...
Junting Hu +10 more
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Role of angiotensin receptor-neprilysin inhibitor in diabetic complications [PDF]
Diabetes mellitus is a prevalent disorder with multi-system manifestations, causing a significant burden in terms of disability and deaths globally. Angio-tensin receptor-neprilysin inhibitor (ARNI) belongs to a class of medications for treating heart ...
Tse, Gary +8 more
core +3 more sources
Frontiers in Physiology, 2018 Chronic hypoxia has been postulated as one of the mechanisms involved in salt-sensitive hypertension and chronic kidney disease (CKD). Kidneys have a critical role in the regulation of arterial blood pressure through vasoactive systems, such as the renin-
Carlos P. Vio +8 more
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