Results 11 to 20 of about 26,340 (266)

Neprilysin Inhibitors and Bradykinin [PDF]

Frontiers in Medicine, 2018
Bradykinin has important physiological actions related to the regulation of blood vessel tone and renal function, and protection from ischemia reperfusion injury.
Duncan J. Campbell, Duncan J. Campbell, Duncan J. Campbell   +2 more
doaj   +4 more sources

Active site mutations change the cleavage specificity of neprilysin. [PDF]

PLoS ONE, 2012
Neprilysin (NEP), a member of the M13 subgroup of the zinc-dependent endopeptidase family is a membrane bound peptidase capable of cleaving a variety of physiological peptides.
Travis Sexton, Lisa J Hitchcook, David W Rodgers, Luke H Bradley, Louis B Hersh   +4 more
doaj   +1 more source

Serum neprilysin levels are associated with myocardial stunning after ST-elevation myocardial infarction

BMC Cardiovascular Disorders, 2020
Background Left ventricular remodeling following ST-elevation myocardial infarction (STEMI) is associated with poor outcome, including heart failure (HF).
Damien Legallois, Clémence Macquaire, Amir Hodzic, Stéphane Allouche, Ismaïl El Khouakhi, Alain Manrique, Paul Milliez, Eric Saloux, Farzin Beygui   +8 more
doaj   +1 more source

Soluble neprilysin and long-term clinical outcomes in patients with coronary artery disease undergoing percutaneous coronary intervention: a retrospective cohort study

BMC Cardiovascular Disorders, 2020
Background Neprilysin has an essential role in regulating fluid balance and vascular resistance, and neprilysin inhibitors have shown beneficial effects in patients with heart failure.
Ik Jun Choi, Sungmin Lim, Youngdeok Hwang, Dongjae Lee, Won Jik Lee, Kwan Yong Lee, Mi-Jeong Kim, Doo Soo Jeon   +7 more
doaj   +1 more source

Effect of Post-Ablational Angiotensin Receptor-Neprilysin Inhibitor on Atrial Fibrillation Recurrence: A Systematic Review and Meta-Analysis in Asian Population. [PDF]

Clin Cardiol
In this meta‐analysis of randomized controlled trials and cohort studies comparing angiotensin receptor‐neprilysin inhibitor (ARNI), angiotensin‐converting enzyme inhibitor and/or angiotensin receptor blocker (ACEI/ARB), and no‐treatment control, the use of ARNI may be effective in preventing the recurrence of atrial fibrillation (AF) after ablation ...
Wang Y, Zhang W, Shao Y, Dong Q, Gu Y, Wang H.   +5 more
europepmc   +2 more sources

Resetting the neurohormonal balance in heart failure (HF). the relevance of the natriuretic peptide (NP) system to the clinical management of patients with HF [PDF]

, 2017
The natriuretic peptide (NP) system, which includes atrial natriuretic peptide, B-type natriuretic peptide, and C-type natriuretic peptide, has an important role in cardiovascular homeostasis, promoting a number of physiological effects including ...
Rubattu, Speranza Donatella, Triposkiadis, Filippos   +1 more
core   +2 more sources

Neprilysin in HFrEF: Differential Regulation of Tissue Versus Circulating Neprilysin.

JACC. Basic to translational science, 2020
[Figure: see text] [Figure: see text]
Chen, Horng H., Burnett, John C.
openaire   +3 more sources

Renal effects and associated outcomes during angiotensin-neprilysin inhibition in heart failure [PDF]

, 2018
Objectives: The purpose of this study was to evaluate the renal effects of sacubitril/valsartan in patients with heart failure and reduced ejection fraction.
Claggett, Brian, Damman, Kevin, Desai, Akshay S., Gori, Mauro, Jhund, Pardeep S., Lefkowitz, Martin P., McMurray, John J.V., Packer, Milton, Prescott, Margaret F., Rouleau, Jean L., Senni, Michele, Shi, Victor C., Solomon, Scott D., Swedberg, Karl, Zile, Michael R.   +14 more
core   +4 more sources

Intranasal neprilysin rapidly eliminates amyloid-beta plaques, but causes plaque compensations: the explanation why the amyloid-beta cascade may fail?

Neural Regeneration Research, 2022
Neurodegenerative brain disorders are a major burden in our society, such as Alzheimer´s disease. In order to repair or prevent such diseases, drugs are designed which enter the brain, but the blood-brain barrier limits their entry and the search for ...
Christian Humpel
doaj   +1 more source

Soluble Neprilysin in the General Population: Clinical Determinants and Its Relationship to Cardiovascular Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Neprilysin is a metalloprotease involved in proteolysis of numerous peptides, including natriuretic peptides, and is of prognostic and therapeutic importance in heart failure with reduced ejection fraction.
Yogesh N. V. Reddy, Seethalakshmi R. Iyer, Christopher G. Scott, Richard J. Rodeheffer, Kent Bailey, Gregory Jenkins, Anthony Batzler, Margaret M. Redfield, John C. Burnett, Naveen L. Pereira   +9 more
doaj   +1 more source