Results 31 to 40 of about 20,710 (242)

Multiple sequence alignment of the amino acid sequence of unigene 25995 with other known neprilysin or neprilysin-like proteins.

, 2015
The aligned sequences are as follows: Oryctolagus cuniculus neprilysin (NP_001095155), Equus przewalskii neprilysin isoform X2 (XP_008519227), Loxodonta africana neprilysin (XP_003416187), Cricetulus griseus neprilysin (XP_007625698), Peromyscus ...
Liming Zhang (213971), Qian He (248656), Dan Liu (108669), Zengliang Ruan (563479), Yonghong Zhou (42434), Qianqian Wang (494839), Guoyan Liu (563480)   +6 more
core   +1 more source

Differences in transition state stabilization between thermolysin (EC 3.4.24.27) and neprilysin (EC 3.4.24.11).

, 1998
Important homologies in the topology of the catalytic site and the mechanism of action of thermolysin and neprilysin have been evidenced by site-directed mutagenesis.
Gilles Tiraboschi, Marie-Claire, Cynthia, Cynthia Marie-Claire, Tiraboschi, Gilles, Ruffet, Emmanuel, Fournie-Zaluski, Marie-Claude, Emmanuel Ruffet, Marie-Claude Fournie-Zaluski   +7 more
core   +6 more sources

Degradation of tropoelastin and skin elastin by neprilysin

, 2018
Neprilysin is also known as skin fibroblast-derived elastase, and its up-regulation during aging is associated with impairments of the elastic fiber network, loss of skin elasticity and wrinkle formation.
Mora Huertas, Angela C., Wolfgang Sippl, Chiara Luise, Christian E.H. Schmelzer, Hoehenwarter, Wolfgang, Sippl, Wolfgang, Schmelzer, Christian E. H., Luise, Chiara, Angela C. Mora Huertas, Heinz, Andrea, Markus Pietzsch, Andrea Heinz, Wolfgang Hoehenwarter, Pietzsch, Markus, Schmelzer, C.E.H., Mora Huertas, A.C., Hoehenwarter, W., Sippl, W., Luise, C., Heinz, A., Pietzsch, M.   +20 more
core   +2 more sources

INNOVATIVE STRATEGY IN THERAPY OF CARDIAC INSUFFICIENCY

Медицинский совет, 2017
The article is devoted to the innovative drug to treat chronic cardiac insufficiency – a combination of sakubitril neprilysin inhibitor and first type angiotension II receptor antagonist valsartan (sacubitril/valsartan).
N. A. Jaiani
doaj   +1 more source

Effect of Neprilysin Inhibition on Alzheimer Disease Plasma Biomarkers: A Secondary Analysis of a Randomized Clinical Trial [PDF]

, 2023
Amyloid-β (Aβ) accumulation is critical in Alzheimer disease (AD), and neprilysin is involved in physiologically clearing Aβ. Concerns exist regarding long-term use of sacubitril/valsartan, a neprilysin inhibitor and angiotensin receptor blocker used for
Scheeren Brum, Wagner,, Blennow, Kaj,, Brum, Wagner S., Zetterberg, Henrik,, Zetterberg, Henrik, McMurray, John J.V., Hansson, Oskar, McMurray, John J. V., Docherty, Kieran F, Docherty, Kieran F., Blennow, Kaj, Ashton, Nicholas J.,, Ashton, Nicholas J., McMurray, John J V, McMurray, John J.V.,, Brum, Wagner S.,, Hansson, Oskar,, Docherty, Kieran F.,, Lund University.   +18 more
core   +1 more source

Autocrine regulation of human sperm motility by tachykinins

Reproductive Biology and Endocrinology, 2010
Background We examined the presence and function of tachykinins and the tachykinin-degrading enzymes neprilysin (NEP) and neprilysin-2 (NEP2) in human spermatozoa.
Pinto Francisco M, Ravina Cristina G, Subiran Nerea, Cejudo-Román Antonio, Fernández-Sánchez Manuel, Irazusta Jon, Garrido Nicolas, Candenas Luz   +7 more
doaj   +1 more source

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

Advanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung, Xu Wang, Bin Liu, Raktim Roy, Nancy Jaiswal, Ratan K. Rai, Yuichiro Takagi, Cen Gao, Lifan Zeng, Ho‐Yin Lo, Reagan K. Wohlford, Ryan K. Higgins, Bruce T. Lamb, Anantha Shekhar, Anita C. Bellail, Chunhai Hao   +15 more
wiley   +1 more source

Hypoxia decreases lung neprilysin expression and increases pulmonary vascular leak

, 2001
Although prior studies suggest that hypoxia may increase pulmonary vascular permeability, the mechanisms responsible for that effect remain uncertain. Neprilysin (neutral endopeptidase) is a cell surface metallopeptidase that degrades several vasoactive
Todd C. Carpenter, Kurt R. Stenmark
core   +1 more source

Protective Effects of ACE/NEP Dual Inhibitor Omapatrilat for Indomethacin-induced Gastric Ulcer

Namık Kemal Tıp Dergisi, 2023
Aim: The renin-angiotensin-aldosterone system (RAAS) plays important roles in oxidative stress and various gastroenterological mechanisms. Omapatrilat, an RAAS-acting agent, inhibits both neprilysin neutral endopeptidase (NEP) and angiotensin converting ...
Kadir Giray ERKAYMAN, Rüstem Anıl UĞAN, Zeynep Berna AKSAKALLI MAĞDEN, Eda YILMAZ, Ayşe BOZKURT, Elif ÇADIRCI   +5 more
doaj   +1 more source

Analyzing Corin–BNP–NEP Protein Pathway Revealing Differential Mechanisms in AF-Related Ischemic Stroke and No AF-Related Ischemic Stroke

Frontiers in Aging Neuroscience, 2022
BackgroundThe incidence of atrial fibrillation (AF)-related stroke increases with aging. Natriuretic peptides (NPs) family, including Corin-B type natriuretic peptide (BNP)-neprilysin (NEP) protein levels increased with age and are risk markers of ...
Xiaozhu Shen, Xiaozhu Shen, Nan Dong, Nan Dong, Yiwen Xu, Lin Han, Rui Yang, Juan Liao, Xianxian Zhang, Tao Xie, Yugang Wang, Chen Chen, Mengqian Liu, Yi Jiang, Liqiang Yu, Qi Fang   +15 more
doaj   +1 more source