Results 31 to 40 of about 16,299 (214)
Autocrine regulation of human sperm motility by tachykinins
Reproductive Biology and Endocrinology, 2010 Background We examined the presence and function of tachykinins and the tachykinin-degrading enzymes neprilysin (NEP) and neprilysin-2 (NEP2) in human spermatozoa.
Pinto Francisco M +7 more
doaj +1 more source
Dynamic Changes in Pentraxin-3 and Neprilysin in ST Segment Elevation Myocardial Infarction
Biomedicines, 2022 Pentraxin-3 (PTX3) and neprilysin have been associated with increased morbidity and mortality in chronic inflammatory disease and heart failure, but these biomarkers have been studied less in patients with ST segment elevation myocardial infarction ...
Rahel Befekadu +4 more
doaj +1 more source
Frontiers in Physiology, 2018 Chronic hypoxia has been postulated as one of the mechanisms involved in salt-sensitive hypertension and chronic kidney disease (CKD). Kidneys have a critical role in the regulation of arterial blood pressure through vasoactive systems, such as the renin-
Carlos P. Vio +8 more
doaj +1 more source
Potential of valsartan+sacubitril therapy in hypertensive heart disease
Российский кардиологический журнал, 2021 The course of hypertension is often complicated by left ventricular hypertrophy (or hypertensive heart disease, HHD). The main “corridor” of natural HHD is development of heart failure with preserved ejection fraction (HFpEF).
A. G. Ovchinnikov +4 more
doaj +1 more source
Roles of Natriuretic Peptides and the Significance of Neprilysin in Cardiovascular Diseases
Biology, 2022 Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) activate the guanylyl cyclase A receptor (GC-A), which synthesizes the second messenger cGMP in a wide variety of tissues and cells.
Hitoshi Nakagawa, Yoshihiko Saito
doaj +1 more source
Brazilian Journal of Medical and Biological Research, 1997 Two intramolecularly quenched fluorogenic peptides containing o-aminobenzoyl (Abz) and ethylenediamine 2,4-dinitrophenyl (EDDnp) groups at amino- and carboxyl-terminal amino acid residues, Abz-DArg-Arg-Leu-EDDnp (Abz-DRRL-EDDnp) and Abz-DArg-Arg-Phe ...
M.A.S. Medeiros +4 more
doaj +1 more source
Molecular Therapy: Methods & Clinical Development, 2020 Amyloid β (Aβ) accumulation in the brain is considered to be one of the major pathological changes in the progression of Alzheimer’s disease (AD). Neprilysin (NEP) is a zinc metallopeptidase that efficiently degrades Aβ.
Yuanli Li +6 more
doaj +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021 Background The gut‐derived hormone GLP‐1 (glucagon‐like peptide‐1) exerts beneficial effects against established risk factors for chronic kidney disease.
Xuefei Liu, Kaushik P. Patel, Hong Zheng
doaj +1 more source
Neprilysin as a Biomarker: Challenges and Opportunities
Cardiac Failure Review, 2020 Neprilysin (NEP) inhibition is a successful novel therapeutic approach in heart failure with reduced ejection fraction. Assessing individual NEP status might be important for gathering insights into mechanisms of disease and optimising individualised patient care.
Pavo, Noemi +4 more
openaire +4 more sources
Neprilysin, obesity and the metabolic syndrome [PDF]
International Journal of Obesity, 2010 Neprilysin (NEP), a zinc metalloendopeptidase, has a role in blood pressure control and lipid metabolism. The present study tested the hypothesis that NEP is associated with insulin resistance and features of the metabolic syndrome (MetS) in a study of 318 healthy human subjects and in murine obesity, and investigated NEP production by adipocytes in ...
Standeven, K F +10 more
openaire +3 more sources