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Neprilysin: Indications, Expectations, and Challenges
Revista Española de Cardiología (English Edition), 2016La neprilisina ha pasado a ser uno de los centros de interes en cardiologia, debido a los impresionantes beneficios que se han demostrado con la combinacion de una inhibicion de la neprilisina y un antagonismo de los receptores de la angiotensina en el reciente ensayo clinico PARADIGM-HF, en el que se evaluo el empleo de LCZ696 (denominado ahora ...
Antoni, Bayes-Genis, Josep, Lupón
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Cell-specific activity of neprilysin 2 isoforms and enzymic specificity compared with neprilysin
Biochemical Journal, 2002Neprilysin (NEP) 2 is a recently cloned glycoprotein displaying a high degree of sequence identity with neprilysin (EC 3.4.24.11), the prototypical member of the M13 subfamily of metalloproteases. Whereas NEP is involved in the metabolism of several bioactive peptides by plasma membranes of various cells, the enzymic properties and physiological ...
Christiane, Rose +4 more
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The role of neprilysin in musculoskeletal diseases
Tissue and CellNeprilysin (NEP) is a membrane-bound endopeptidase that degrades various substrates, including natriuretic peptide, bradykinin, and substance P. It is distributed in various organs such as the heart, kidneys, and brain, regulating multiple physiological processes.
Zuping Wu +4 more
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The Neprilysin Family in Health and Disease
2006The mammalian neprilysin (NEP) family comprises at least seven members: NEP itself, Kell blood group antigen (KELL), the endothelin-converting enzymes (ECE-1 and ECE-2), the enzyme PEX, associated with X-linked hypophosphataemia, "X-converting enzyme" (XCE) a CNS-expressed orphan peptidase and a soluble, secreted endopeptidase (SEP).
A J, Turner +3 more
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Convoluted molecular maze of neprilysin
Diagnosis, 2022Eleftherios P. Diamandis +2 more
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Tumour suppression through modulation of neprilysin signaling: A comprehensive review
European Journal of Pharmacology, 2021Sreedhara Ranganath Pai +2 more
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A Test in Context: Neprilysin: Function, Inhibition, and Biomarker.
Journal of the American College of Cardiology, 2016Mark Richards +2 more
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