Discontinuation of Heart Failure Pharmacotherapy in Older Adults With Frailty. [PDF]
J Am Heart AssocNakamaru R +5 more
europepmc +1 more source
Correction to "The Interleukin-1α Stimulated Expression of the Wrinkle-Inducing Elastase Neprilysin in Adult Human Dermal Fibroblasts Is Mediated via the Intracellular Signaling Axis of ERK/JNK/c-Jun/c-Fos/AP-1". [PDF]
J Dermatoleuropepmc +1 more source
Soluble Neprilysin and Corin Concentrations in Relation to Clinical Outcome in Chronic Heart Failure
JACC: Heart Failure, 2021 OBJECTIVES: This study investigated whether patients with chronic heart failure (HF) can be stratified according to the combination of soluble neprilysin and corin concentrations and whether this is related to clinical outcome.
Priya Vart, Elena Revuelta, Mar Domingo
exaly +2 more sources
Neprilysin inhibition: a new therapeutic option for type 2 diabetes?
Diabetologia, 2019 peer reviewedNeprilysin is a widely expressed peptidase with broad substrate specificity that preferentially hydrolyses oligopeptide substrates, many of which regulate the cardiovascular, nervous and immune systems.
Nathalie Esser, Sakeneh Zraika
exaly +2 more sources
Neprilysin inhibition to treat heart failure: a tale of science, serendipity, and second chances
European Journal of Heart Failure, 2015 This review describes the role of neprilysin (also known as neutral endopeptidase or enkephalinase) in the degradation of natriuretic and other vasoactive peptides, including bradykinin and adrenomedullin. The initial development of neprilysin inhibitors,
John McMurray
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Copper Downregulates Neprilysin Activity Through Modulation of Neprilysin Degradation
Journal of Alzheimer's Disease, 2010Copper plays a central role in conserved processes such as respiration, and in highly specialized processes, such as protein modification. The metalloprotease neprilysin (NEP) degrades a variety of bioactive peptides and is involved in many physiological processes. However, very little is known about the regulation of NEP activity. In the current study,
Li Mi +6 more
openaire +2 more sources
Neuroendocrine Differentiation, Neuropeptides, and Neprilysin
American Journal of Respiratory Cell and Molecular Biology, 1999Pulmonary neuroendocrine cells exhibit highly specialized differentiation with a neurosecretory phenotype and significant bioactive peptide hormone content. In addition to these functions, pulmonary neuroendocrine cells have been demonstrated to act as chemoreceptors for hypoxia (1).
A J, Cohen, Y E, Miller
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Tat peptides inhibit neprilysin
Journal of Neurovirology, 2006Dementia associated with human immunodeficiency virus (HIV) infection occurs commonly in the aging population and amyloid depositions are noted in the brains of patients with HIV infection in younger age groups. This suggests a dysregulation of amyloid processing in the setting of HIV infection.
Abigail, Daily +2 more
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Neprilysin Inhibitors in Cardiovascular Disease
Current Cardiology Reports, 2017Mortality from heart failure remains high despite advances in medical therapy over the last three decades. Angiotensin receptor-neprilysin inhibitor (ARNI) combinations are the latest addition to the heart failure medical armamentarium, which is built on the cornerstone regimen of beta blockers, angiotensin converting enzyme (ACE) inhibitors ...
Guson, Kang, Dipanjan, Banerjee
openaire +2 more sources