Results 171 to 180 of about 16,299 (214)
A-DEGRADING ENZYME,NEPRILYSINSome of the next articles are maybe not open access.
Related searches:
Related searches:
Copper Downregulates Neprilysin Activity Through Modulation of Neprilysin Degradation
Journal of Alzheimer's Disease, 2010Copper plays a central role in conserved processes such as respiration, and in highly specialized processes, such as protein modification. The metalloprotease neprilysin (NEP) degrades a variety of bioactive peptides and is involved in many physiological processes. However, very little is known about the regulation of NEP activity. In the current study,
Li Mi +6 more
openaire +2 more sources
Neuroendocrine Differentiation, Neuropeptides, and Neprilysin
American Journal of Respiratory Cell and Molecular Biology, 1999Pulmonary neuroendocrine cells exhibit highly specialized differentiation with a neurosecretory phenotype and significant bioactive peptide hormone content. In addition to these functions, pulmonary neuroendocrine cells have been demonstrated to act as chemoreceptors for hypoxia (1).
A J, Cohen, Y E, Miller
openaire +2 more sources
Tat peptides inhibit neprilysin
Journal of Neurovirology, 2006Dementia associated with human immunodeficiency virus (HIV) infection occurs commonly in the aging population and amyloid depositions are noted in the brains of patients with HIV infection in younger age groups. This suggests a dysregulation of amyloid processing in the setting of HIV infection.
Abigail, Daily +2 more
openaire +2 more sources
Neprilysin Inhibitors in Cardiovascular Disease
Current Cardiology Reports, 2017Mortality from heart failure remains high despite advances in medical therapy over the last three decades. Angiotensin receptor-neprilysin inhibitor (ARNI) combinations are the latest addition to the heart failure medical armamentarium, which is built on the cornerstone regimen of beta blockers, angiotensin converting enzyme (ACE) inhibitors ...
Guson, Kang, Dipanjan, Banerjee
openaire +2 more sources
Neprilysin: Indications, Expectations, and Challenges
Revista Española de Cardiología (English Edition), 2016La neprilisina ha pasado a ser uno de los centros de interes en cardiologia, debido a los impresionantes beneficios que se han demostrado con la combinacion de una inhibicion de la neprilisina y un antagonismo de los receptores de la angiotensina en el reciente ensayo clinico PARADIGM-HF, en el que se evaluo el empleo de LCZ696 (denominado ahora ...
Antoni, Bayes-Genis, Josep, Lupón
openaire +2 more sources
Cell-specific activity of neprilysin 2 isoforms and enzymic specificity compared with neprilysin
Biochemical Journal, 2002Neprilysin (NEP) 2 is a recently cloned glycoprotein displaying a high degree of sequence identity with neprilysin (EC 3.4.24.11), the prototypical member of the M13 subfamily of metalloproteases. Whereas NEP is involved in the metabolism of several bioactive peptides by plasma membranes of various cells, the enzymic properties and physiological ...
Christiane, Rose +4 more
openaire +2 more sources
The Neprilysin Family in Health and Disease
2006The mammalian neprilysin (NEP) family comprises at least seven members: NEP itself, Kell blood group antigen (KELL), the endothelin-converting enzymes (ECE-1 and ECE-2), the enzyme PEX, associated with X-linked hypophosphataemia, "X-converting enzyme" (XCE) a CNS-expressed orphan peptidase and a soluble, secreted endopeptidase (SEP).
A J, Turner +3 more
openaire +2 more sources
The role of neprilysin in musculoskeletal diseases
Tissue and CellNeprilysin (NEP) is a membrane-bound endopeptidase that degrades various substrates, including natriuretic peptide, bradykinin, and substance P. It is distributed in various organs such as the heart, kidneys, and brain, regulating multiple physiological processes.
Zuping Wu +4 more
openaire +2 more sources
Regulation of Thymic Development by Neprilysin Inhibition
1997Development of T lymphocyte is regulated by both thymocyte-stromal cell interactions and production of soluble factors such as cytokines, peptides and hormones. The local concentration of active biological peptides is regulated by a specialized family of enzymes expressed at the cell surface, the ectopeptidases.
S, Guérin, P, Auberger
openaire +2 more sources