Results 161 to 170 of about 26,340 (266)

Gene–Environment Interactions for Alzheimer's Disease Pathology in Cognitively Normal Adults: The CABLE Study

European Journal of Neurology, Volume 33, Issue 4, April 2026.
This study investigated gene–environment interactions in Alzheimer's disease (AD) pathology among 1007 cognitively normal adults from the CABLE cohort. Higher AD polygenic risk scores were associated with increased amyloidosis, with significant interactions observed between genetic risk and three modifiable factors—anemia, gingivitis, and anxiety—in ...
Ze‐Xin Guo, Xiao‐Yu He, Yi‐Jun Ge, Bing Zhao, Liang‐Yu Huang, Shi‐Dong Chen, Yan Fu, Pei‐Yang Gao, Ze‐Hu Sheng, Yi‐Ming Huang, Qiong‐Yao Li, Lan Tan   +11 more
wiley   +1 more source

Sacubitril/Valsartan Attenuates Inflammation and Fibrosis Associated With Decreased Integrin α8 and Inhibits Hepatocarcinogenesis in a Rat Model of Metabolic Dysfunction‐Associated Steatohepatitis

Hepatology Research, Volume 56, Issue 4, Page 420-435, April 2026.
Sacubitril/Valsartan (Sac/Val) alleviates fibrosis and inflammation in metabolic dysfunction‐associated steatohepatitis (MASH). Its anti‐fibrotic effect is linked to the suppression of Integrin alpha 8 (Itga8), a protein crucial for hepatic stellate cell (HSC) activation and collagen production.
Hayato Kawamura, Aya Naiki‐Ito, Xiaochen Kuang, Akihiro Murakami, Masayuki Komura, Takanori Suzuki, Hiroyuki Kato, Yuko Nagayasu, Kentaro Matsuura, Kei Fujiwara, Hiromi Kataoka, Satoru Takahashi   +11 more
wiley   +1 more source

Studi Docking Molekuler Penghambatan Reseptor Neprilysin Bunga Lawang (Illicium verum) sebagai Anti Hipertensi dan Prediksi Profil Farmakokinetikanya

Jurnal Ilmiah Biosaintropis (Bioscience-Tropic), 2023
Andri Tilaqza, Merlita Herbani, Zaenab Aqilah   +2 more
doaj   +1 more source

Soluble neprilysin and the translational continuum in cardio-oncology. [PDF]

Cardiooncology
Camilli M, Abbate A.
europepmc   +1 more source

Circulating neprilysin hypothesis

Circulating Neprilysin (sNEP) has emerged as a potential prognostic biomarker in heart failure (HF). In PARAGON-HF benefit of sacubitril/valsartan was only observed in patients with left ventricular ejection fraction (LVEF) ≤57%. We aimed to assess the prognostic value of sNEP in outpatients with HF and LVEF >57%, in comparison with patients with LVEF ≤
Lupón, Josep||, Santiago Vacas, Evelyn||, Cediel, Germán||, Codina, Pau||, Domingo, Mar||, Revuelta-López, Elena||, Zamora, Elisabet||, Spitaleri, Giosafat||, Santesmases, Javier||, Núñez, Julio||, Bayés-Genís, Antoni||   +10 more
openaire   +1 more source

Associations of 24‐Hour Urinary Sodium, Potassium Excretion and Sodium‐to‐Potassium Ratio With Longitudinal Home Blood Pressure Control in Patients With Apparent Treatment‐Resistant Hypertension

The Journal of Clinical Hypertension, Volume 28, Issue 4, April 2026.
ABSTRACT Dietary sodium and potassium intake are key determinants of blood pressure (BP) control in hypertensive patients. However, their associations with longitudinal home BP control in patients with apparent treatment‐resistant hypertension (aTRH) remain unclear.
Weikang Bian, Fanglu Wang, Hao Wang, Qiaoyu Shao, Shicheng Li, Shuyang Zhang, Xiaowei Yan   +6 more
wiley   +1 more source

Association between angiotensin receptor-neprilysin inhibitor use and clinical outcomes in patients with heart failure: a 1-year prospective cohort study from Jordan. [PDF]

BMJ Open
Odeh RS, Abdel Jalil M, Qudah MA, Al-Makhamreh HK, Saleh A, Awwad O.   +5 more
europepmc   +1 more source

Soluble neprilysin is associated with myocardial damage and systolic dysfunction in an animal model of doxorubicin-induced cardiotoxicity. [PDF]

Cardiooncology
Sobiborowicz-Sadowska AM, Kamińska K, Sztechman D, Matusik K, Koperski Ł, Borensztejn K, Cudnoch-Jędrzejewska A.   +6 more
europepmc   +1 more source

Editorial: Clearance Pathways for Amyloid-β. Significance for Alzheimer's Disease and Its Therapy

Frontiers in Aging Neuroscience, 2017
Roxana O. Carare
doaj   +1 more source

Discontinuation of Heart Failure Pharmacotherapy in Older Adults With Frailty. [PDF]

J Am Heart Assoc
Nakamaru R, Nishimura S, Kumamaru H, Daigo K, Walsh KM, Kohsaka S.   +5 more
europepmc   +1 more source