Results 141 to 150 of about 26,340 (266)
Aging Cell, Volume 25, Issue 5, May 2026.We provide the first human evidence that the exercise‐induced myokine irisin mediates the relationship between physical activity and hippocampal volume in older adults, with strongest effects in CA1, CA3 and CA4 subfields. These regions are critical for memory and particularly vulnerable to Alzheimer's disease.
Thomas Pace +5 more
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 10, Page 2236-2255, May 2026.Abstract Background and Purpose Plasma glucocorticoids increase acutely after MI, thereafter tissue levels are amplified selectively within cells expressing 11‐ßhydroxysteroid dehydrogenase type 1 (11‐ßHSD1) that regenerates active glucocorticoids from circulating metabolites.
Sara Al Disi +19 more
wiley +1 more source
Advanced Science, Volume 13, Issue 20, 9 April 2026.Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin +12 more
wiley +1 more source
Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.Abstract INTRODUCTION Although several plasma tau phosphorylated at threonine 217 (p‐tau217) immunoassays are now available, comprehensive analytical validation remains limited. We therefore evaluated the Lumipulse G plasma p‐tau217 assay and verified established cutoffs for clinical implementation.
Burak Arslan +14 more
wiley +1 more source
Spotlight on valsartan–sacubitril fixed-dose combination for heart failure: the evidence to date
Drug Design, Development and Therapy, 2016 José Fernando Vilela-Martin Internal Medicine Department, São José do Rio Preto State Medical School (FAMERP), São José do Rio Preto, Brazil Abstract: Heart failure is a global problem with elevated prevalence, and it
Vilela-Martin JF
doaj
Cancer Medicine, Volume 15, Issue 4, April 2026.ABSTRACT Introduction and Methods Cancer therapy–related cardiac dysfunction (CTRCD) is a well established and potentially life‐threatening complication of contemporary oncologic treatment. Although comprehensive cardio‐oncology guidelines have been developed, their integration into routine hematology and oncology practice remains inconsistent.
Abdelrahman Ali +22 more
wiley +1 more source
Consequences of Amyloid‐β Deficiency for the Liver
Advanced ScienceThe hepatic content of amyloid beta (Aβ) decreases drastically in human and rodent cirrhosis highlighting the importance of understanding the consequences of Aβ deficiency in the liver.
Gayane Hrachia Buniatian +21 more
doaj +1 more source
Clinical Case Reports, Volume 14, Issue 4, April 2026.Echocardiographic findings in dilated cardiomyopathy secondary to untreated acromegaly. (A) Apical four‐chamber view showing biventricular and biatrial dilation. (B‐C) Colour Doppler demonstrating mitral, aortic, and tricuspid regurgitation. (D) Reduced global longitudinal strain (GLS: −6.5%), consistent with severe systolic dysfunction.
Cristian Orlando Porras Bueno +4 more
wiley +1 more source
The effect of angiotensin receptor neprilysin inhibitor, sacubitril/valsartan, on central nervous system amyloid-β concentrations and clearance in the cynomolgus monkey [PDF]
, 2017 Bateman, Randy J, et al,
core +2 more sources
Clinical Cardiology, Volume 49, Issue 4, April 2026.In patients with HFpEF and HFmrEF, maximal inspiratory pressure is independently associated with exercise capacity, including peak oxygen uptake and 6‐minute walk distance, as well as left atrial reservoir strain. These findings highlight inspiratory muscle strength as a relevant functional determinant of exercise intolerance, independent of age and ...
Huu Dat Tran +4 more
wiley +1 more source