Results 131 to 140 of about 20,710 (242)
Gut-Specific Neprilysin Deletion Protects Against Fat-Induced Insulin Secretory Dysfunction In Male Mice. [PDF]
peer reviewedNeprilysin is a ubiquitous peptidase that can modulate glucose homeostasis by cleaving insulinotropic peptides. While global deletion of neprilysin protects mice against high fat diet (HFD)-induced insulin secretory dysfunction, strategies ...
Zraika, Sakeneh +3 more
core +1 more source
SGLT2i in heart failure: Cardiorenal mechanisms, clinical evidence and translational perspectives
Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.SGLT2 inhibitors improve heart failure outcomes through integrated cardiorenal mechanisms. In the kidney, they reduce glucose and sodium reabsorption, promoting natriuresis, osmotic diuresis and renal protection. In the heart, they enhance myocardial energetics, reduce inflammation, oxidative stress, fibrosis and adverse remodelling, resulting in fewer
Jelica Grujic‐Milanovic +4 more
wiley +1 more source
Journal of Arrhythmia, Volume 42, Issue 5, October 2026.ABSTRACT Atrial fibrillation (AF) is closely associated with comorbidities and lifestyle factors that influence the development, progression, and outcomes. Here the focus is on guidelines for the systematic management of hypertension, heart failure, coronary and structural heart disease, diabetes, dyslipidemia, cerebrovascular disease, obesity, chronic
Eue‐Keun Choi +16 more
wiley +1 more source
Journal of Arrhythmia, Volume 42, Issue 5, October 2026.No significant difference in appropriate ICD therapies between treatment eras. Time to first ICD therapy was similar after propensity‐score matching. The result was robust to a sensitivity analysis using an expanded propensity model. Cumulative incidence, accounting for competing risk of death, was also higher.
Inês Ferreira Neves +11 more
wiley +1 more source
MedComm, Volume 7, Issue 10, October 2026.In a nationwide heart failure cohort, cardiovascular–kidney–metabolic (CKM) multimorbidity was common in Chinese hospitalized heart failure (HF) patients and associated with poor prognosis. Higher CKM burden and combinations identified high‐risk patients.
Xiang Wang +15 more
wiley +1 more source
Journal of Diabetes, Volume 18, Issue 10, October 2026.Proteomic profiling identified SCGB3A2 as a novel biomarker associated with impaired coronary collateralization in patients with chronic total occlusion and Type 2 diabetes. Independent validation supports its potential for risk stratification. ABSTRACT Background Type 2 diabetes mellitus (T2DM) is associated with impaired coronary collateralization in
Jian‐Jun Chen +7 more
wiley +1 more source
European Journal of Clinical Investigation, Volume 56, Issue 10, October 2026.Clinical and translational readiness of IL‐6 measurement in HFrEF. ABSTRACT Background Interleukin‐6 (IL‐6) is frequently measured in heart failure with reduced ejection fraction (HFrEF), but its clinical utility remains unclear. Objectives To assess IL‐6 as a biomarker in HFrEF, with emphasis on the effect of treatments (pharmacodynamics) and ...
Yongxin Ye +11 more
wiley +1 more source
Journal of Diabetes Investigation, Volume 17, Issue 10, Page 1759-1769, October 2026.This prespecified subgroup analysis of the BIRDIE study demonstrated that Bifidobacterium bifidum G9‐1 improved stool consistency, bowel movement, and quality of life in patients with type 2 diabetes mellitus, chronic kidney disease, and specifically in age ≥ 65 years, male, and those with eGFR ≥60 mL/min/1.73 m2.
Fuki Ikeda +8 more
wiley +1 more source