Results 231 to 240 of about 14,163 (275)
ESC Heart Failure, Volume 12, Issue 3, Page 2210-2224, June 2025.Abstract Aims Cardiac resynchronization therapy (CRT) improves the prognosis of patients with heart failure (HF) and wide QRS complex. However, patients with non‐left bundle branch block (LBBB) show a poor response to CRT. This study evaluated myocardial work estimated by pressure–strain loops on echocardiography for predicting response to CRT in ...
Shun Kondo +12 more
wiley +1 more source
Journal of Arrhythmia, Volume 41, Issue 3, June 2025.Abstract Background Sick sinus syndrome (SSS) is associated with atrial fibrillation (AF) and heart failure with preserved ejection fraction (HFpEF). However, diagnosing HFpEF in patients with SSS and determining its prognosis are challenging. The European Society of Cardiology has recommended the HFA‐PEFF score for HFpEF diagnosis.
Hironobu Sumiyoshi +6 more
wiley +1 more source
Fundamental &Clinical Pharmacology, Volume 39, Issue 3, June 2025.Abstract Background Metabolic syndrome (MetS) is a multifaceted disease associated with heart failure (HF), which affects the vascular system. The endothelin (ET) system is a key player in MetS and HF; therefore, targets for ET receptors are of therapeutic interest.
Francesca Lockwood +11 more
wiley +1 more source
Cancer Medicine, Volume 14, Issue 9, May 2025.We identified 156 novel miRNAs through de novo prediction in the newly discovered genomic regions of T2T‐CHM13. These miRNAs target 345 protein‐coding genes that are downregulated in collecting duct renal cell carcinoma (cdRCC). The miRNAs may play a role in the disease by altering several key tumor suppressor pathways and targeting multiple tumor ...
Anik Mojumder +2 more
wiley +1 more source
Enzymatic Production of Opine‐Type Chiral Amines with Controlled Stereoselectivity
ChemCatChem, Volume 17, Issue 9, May 8, 2025.The remarkable behavior of a ketimine reductase to enable control over the newly formed stereocenter in the reductive amination between α‐keto acids and α‐amino esters is reported. Mechanistic understanding for this unique property is provided at the molecular level within the enzyme active site.
András Telek +5 more
wiley +1 more source
Medicinal Research Reviews, Volume 45, Issue 3, Page 985-1015, May 2025.ABSTRACT This review provides a comprehensive overview of the role of G9a/EHMT2, focusing on its structure and exploring the impact of its pharmacological and/or gene inhibition in various neurological diseases. In addition, we delve into the advancements in the design and synthesis of G9a/EHMT2 inhibitors, which hold promise not only as a treatment ...
Aina Bellver‐Sanchis +10 more
wiley +1 more source
Annals of Noninvasive Electrocardiology, Volume 30, Issue 3, May 2025.In CRT‐D patients with LVEF above guideline indications, LVEF 36%–40%, absence of LBBB, and a history of VTA increase the risk for future VTA. These patients require close monitoring despite improvement beyond guideline recommendations. ABSTRACT Background Patients undergoing cardiac resynchronization therapy with a defibrillator (CRT‐D) often ...
Adam Visca +10 more
wiley +1 more source
Annals of Noninvasive Electrocardiology, Volume 30, Issue 3, May 2025.Patients undergoing SV therapy had significantly less VTVF events and associated clinical interventions. This effect could lead to less possibility of lethal arrhythmia and sudden cardiac death. ABSTRACT Background Patients with heart failure with reduced ejection fraction (HFrEF) frequently experience electrical disturbances, such as ventricular or ...
Alireza Arzhangzadeh +14 more
wiley +1 more source
Mechanisms of diabetic cardiomyopathy: Focus on inflammation
Diabetes, Obesity and Metabolism, Volume 27, Issue 5, Page 2326-2338, May 2025.Abstract Purpose of Review Type 2 diabetes (T2D) significantly increases the risk of heart failure (HF), either through the progression of coronary artery disease (CAD) or through direct myocardial alterations, termed diabetic cardiomyopathy. This review examines key pathophysiological mechanisms underlying diabetic cardiomyopathy, focusing on the role
Myriam Bellemare +5 more
wiley +1 more source
The Journal of Clinical Hypertension, Volume 27, Issue 5, May 2025.ABSTRACT Hypertension (HTN) is a significant risk factor for heart failure (HF), and both significantly contribute to cardiovascular mortality. This study aims to examine trends and disparities in HF‐related mortality among hypertensive older adults (≥65 years) in the United States from 1999 to 2020.
Ahmed Raza +6 more
wiley +1 more source