Results 231 to 240 of about 25,082 (343)

DIGitoxin to Improve ouTcomes in patients with advanced chronic Heart Failure (DIGIT‐HF): Baseline characteristics compared to recent randomized controlled heart failure trials

European Journal of Heart Failure, EarlyView.
Effects of digitoxin compared to placebo on efficacy and safety in patients with heart failure and reduced ejection fraction (HFrEF). Primary endpoint: time to all‐cause death and first hospitalization for worsening heart failure (whatever occurs first). ACEi, angiotensin‐converting enzyme inhibitor; ARB, angiotensin receptor blocker; ARNI, angiotensin
Udo Bavendiek, Nele Henrike Thomas, Dominik Berliner, Xiaofei Liu, Johannes Schwab, Andreas Rieth, Lars S. Maier, Sven Schallhorn, Eleonora Angelini, Samira Soltani, Fabian Rathje, Mircea‐Andrei Sandu, Welf Geller, Thomas Gaspar, Rainer Hambrecht, Marija Zdravkovic, Sebastian Philipp, Dragana Kosevic, Georg Nickenig, Daniel Scheiber, Sebastian Winkler, Peter Moritz Becher, Philipp Lurz, Martin Hülsmann, Maria von Karpowitz, Christoph Schröder, Barbara Neuhaus, Anika Seltmann, Heiko von der Leyen, Christian Veltmann, Stefan Störk, Michael Böhm, Armin Koch, Anika Großhennig, Johann Bauersachs, on behalf of the DIGIT‐HF Study Group   +35 more
wiley   +1 more source

N‐terminal domain of Bothrops asper Myotoxin II Enhances the Activity of Endothelin Converting Enzyme and Neprilysin [PDF]

, 2016
Sanjaya Kuruppu, Niwanthi W. Rajapakse, Oded Kleifeld, David H. Small, James C. Whisstock, A. Ian Smith   +5 more
openalex   +1 more source

Anaemia in patients with heart failure and mildly reduced or preserved ejection fraction: A prespecified analysis of the FINEARTS‐HF trial

European Journal of Heart Failure, EarlyView.
ABSTRACT Aims Anaemia is common in heart failure with mildly reduced or preserved ejection fraction (HFmrEF/HFpEF) and associated with poor clinical outcomes. While renin–angiotensin system blockers reduce haemoglobin, little is known about the effect of mineralocorticoid receptor antagonists on haemoglobin and in patients with anaemia.
Misato Chimura, Mingming Yang, Alasdair D. Henderson, Pardeep S. Jhund, Kieran F. Docherty, Brian L. Claggett, Akshay S. Desai, Gerasimos Filippatos, Grzegorz Gajos, Katharina Mueller, Andrea Glasauer, Katja Rohwedder, Prabhakar Viswanathan, Carolyn S.P. Lam, Naoki Sato, Michele Senni, Adriaan A. Voors, Faiez Zannad, Mehmet B. Yilmaz, Bertram Pitt, Muthiah Vaduganathan, Scott D. Solomon, John J.V. McMurray, on behalf of the FINEARTS‐HF Committees and Investigators   +23 more
wiley   +1 more source

Albuminuria as a diagnostic criterion and a therapeutic target in heart failure and other cardiovascular disease

European Journal of Heart Failure, EarlyView.
The value of uACR. CKD, chronic kidney disease; CVD, cardiovascular disease; eGFR, estimated glomerular filtration rate; uACR, urine albumin‐to‐creatinine ratio. Abstract The high disease burden and bidirectional relationship of chronic kidney disease (CKD), heart failure (HF) and other cardiovascular disease (CVD) necessitate the need for early ...
Biykem Bozkurt, Patrick Rossignol, Joseph A. Vassalotti   +2 more
wiley   +1 more source

Implications of HFpEF Definitions Unveiled by Rest and Exercise Hemodynamics. [PDF]

Circ Res
Landsteiner I, Ikoma T, Ramesh A, Campain J, Cohen LP, Hardin CC, Malhotra R, Lewis GD.   +7 more
europepmc   +1 more source

Safety and tolerability of a 5 mg starting dose of vericiguat among patients with heart failure: The VELOCITY study

European Journal of Heart Failure, EarlyView.
ABSTRACT Aims In clinical practice, simplifying the number of medication titration steps while maintaining safety may improve the likelihood of patients with heart failure (HF) achieving target doses of guideline‐directed medical therapy (GDMT).
Stephen J. Greene, Stefano Corda, Ciaran J. McMullan, Giovanni Palombo, Christina Schooss, Vanja Vlajnic, Katrin Walkamp, Michele Senni, on behalf of the VELOCITY investigators   +8 more
wiley   +1 more source

Exploring safety of down‐titrating diuretics in heart failure management

European Journal of Heart Failure, EarlyView.
Event probabilities following down‐titration (), up‐titration (), or no dose change (=). One person represents approximately 10% of cases. Abstract Aims Loop diuretics are widely used in heart failure (HF) for symptom relief. Guidelines advise treating patients with the lowest possible dose of loop diuretics to maintain euvolaemia, based on expert ...
Chrit B.G. Geraeds, Anke Bruninx, Andre L.A.J. Dekker, Arantxa Barandiarán Aizpurua, Inigo Bermejo, Hans‐Peter Brunner‐La Rocca   +5 more
wiley   +1 more source

Cardiac resynchronization therapy for enabling guideline‐directed medical therapy optimization in heart failure

European Journal of Heart Failure, EarlyView.
Cardiac resynchronization therapy (CRT) as an enabler for guideline‐directed medical therapy (GDMT) in the Swedish Heart Failure Registry (SwedeHF). The figure summarizes the selection of the study population, changes in GDMTs and loop diuretic use/doses from baseline to 1.5‐year follow‐up in patients receiving versus not receiving CRT, and reports the
Daniela Tomasoni, Lina Benson, Paolo Gatti, Alessandro Villaschi, Charlotta Ljungman, Marco Metra, Raffaele Scorza, Frieder Braunschweig, Michael Melin, Giuseppe Rosano, Michael Böhm, Javed Butler, William T. Abraham, Wilfried Mullens, Fredrik Gadler, Cecilia Linde, Lars H. Lund, Gianluigi Savarese   +17 more
wiley   +1 more source

Granulocyte-Colony Stimulating Factor Attenuates Oligomeric Amyloid β Neurotoxicity by Activation of Neprilysin

, 2014
Yukiko Doi, Hideyuki Takeuchi, Hiroyuki Mizoguchi, Kazuya Fukumoto, Hiroshi Horiuchi, Shijie Jin, Jun Kawanokuchi, Bijay Parajuli, Yoshifumi Sonobe, Tetsuya Mizuno, Akio Suzumura   +10 more
openalex   +2 more sources

Urinary Proteome Analysis Identified Neprilysin and VCAM as Proteins Involved in Diabetic Nephropathy [PDF]

, 2018
Elena Guillén‐Gómez, Beatriz Bardají, S Ferrer, Carlos Brotons, Mark A. Knepper, Montserrat Carrascal, Joaquín Abián, José Manuel Mas, Francesca Calero, José Ballarín, Patricia Fernández‐Llama   +10 more
openalex   +1 more source