Results 241 to 250 of about 14,163 (275)

Paeonol Improves Cardiac Remodelling in MI Mice by Suppressing NOX2 mRNA Expression to Mitigate Oxidative Stress and Mitochondrial Dysfunction

Journal of Cellular and Molecular Medicine, Volume 29, Issue 9, May 2025.
ABSTRACT Myocardial infarction (MI), a primary contributor to mortality from cardiovascular diseases, continues to pose a significant challenge in clinical treatment. In this study, our objective was to investigate the cardioprotective effects of paeonol (PAE) on mice with MI, and to delve into the precise mechanisms underlying these effects.
Yun Liu, Zhiming Wu, Xiaoping jin, Meili Ji, Tianyi Huang, Peina Meng, Tian Xu, Wei You, Yanfang Zhao, Fei Ye, Xiangqi Wu   +10 more
wiley   +1 more source

Effect of administration and withdrawal of the sodium‐glucose cotransporter 2 inhibitor, tofogliflozin, on renal protection in individuals with type 2 diabetes mellitus and diabetic nephropathy: A multicenter, single‐arm study (RESTORE‐nephropathy study)

Journal of Diabetes Investigation, Volume 16, Issue 5, Page 817-826, May 2025.
Urinary albumin/creatinine ratio significantly decreased, increased, and again decreased during the period of the 1st administration, withdrawal, and re‐administration of tofogliflozin, respectively. In contrast, serum creatinine increased during the 1st administration and re‐administration period of tofogliflozin and throughout the observation period,
Ayako Shigeta, Masami Tanaka, Shu Meguro, Jiro Morimoto, Takatoshi Imai, Akira Yamauchi, Yasuhiko Kanazawa, Toshihide Kawai, Koichiro Azuma, Satoru Yamada, Sho Endo, Hiroshi Itoh, Kaori Hayashi   +12 more
wiley   +1 more source

Copper Downregulates Neprilysin Activity Through Modulation of Neprilysin Degradation [PDF]

Journal of Alzheimer's Disease, 2010
Copper plays a central role in conserved processes such as respiration, and in highly specialized processes, such as protein modification. The metalloprotease neprilysin (NEP) degrades a variety of bioactive peptides and is involved in many physiological processes. However, very little is known about the regulation of NEP activity. In the current study,
Huan Yang, Dongsheng Fan, Miao Sun, Yi Liu, Mi Li, Dehua Chui, Jia Yu   +6 more
openaire   +2 more sources

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Renal events in patients receiving Neprilysin inhibitors: a systematic review and meta-analysis.

Nephrology, Dialysis and Transplantation, 2022
BACKGROUND While it is well known that angiotensin converting enzyme inhibitors (ACEi)/angiotensin receptor blockers (ARBs) increase the risk of acute renal failure1,2, the role of neprilysin inhibition (NEPi) is unclear and some physicians are reluctant
Clara Vollmer Barbosa, H. Lang, A. Melk, B. Schmidt   +3 more
semanticscholar   +1 more source

Tat peptides inhibit neprilysin

Journal of Neurovirology, 2006
Dementia associated with human immunodeficiency virus (HIV) infection occurs commonly in the aging population and amyloid depositions are noted in the brains of patients with HIV infection in younger age groups. This suggests a dysregulation of amyloid processing in the setting of HIV infection.
Abigail Daily, Avindra Nath, Louis B. Hersh   +2 more
openaire   +3 more sources

Neprilysin: Indications, Expectations, and Challenges

Revista Española de Cardiología (English Edition), 2016
La neprilisina ha pasado a ser uno de los centros de interes en cardiologia, debido a los impresionantes beneficios que se han demostrado con la combinacion de una inhibicion de la neprilisina y un antagonismo de los receptores de la angiotensina en el reciente ensayo clinico PARADIGM-HF, en el que se evaluo el empleo de LCZ696 (denominado ahora ...
Antoni Bayes-Genis, Josep Lupón
openaire   +3 more sources

Neprilysin Inhibitors in Cardiovascular Disease

Current Cardiology Reports, 2017
Mortality from heart failure remains high despite advances in medical therapy over the last three decades. Angiotensin receptor-neprilysin inhibitor (ARNI) combinations are the latest addition to the heart failure medical armamentarium, which is built on the cornerstone regimen of beta blockers, angiotensin converting enzyme (ACE) inhibitors ...
Dipanjan Banerjee, Guson Kang
openaire   +3 more sources

The dopaminergic system promotes neprilysin-mediated degradation of amyloid-β in the brain

Science Signaling
Deposition of amyloid-β (Aβ) in the brain can impair neuronal function and contribute to cognitive decline in Alzheimer’s disease (AD). Here, we found that dopamine and the dopamine precursor levodopa (also called l-DOPA) induced Aβ degradation in the ...
Naoto Watamura, Naomasa Kakiya, Ryo Fujioka, Naoko Kamano, Mika Takahashi, Per Nilsson, Takashi Saito, Nobuhisa Iwata, Shigeyoshi Fujisawa, T. Saido   +9 more
semanticscholar   +1 more source

Neuroendocrine Differentiation, Neuropeptides, and Neprilysin

American Journal of Respiratory Cell and Molecular Biology, 1999
Pulmonary neuroendocrine cells exhibit highly specialized differentiation with a neurosecretory phenotype and significant bioactive peptide hormone content. In addition to these functions, pulmonary neuroendocrine cells have been demonstrated to act as chemoreceptors for hypoxia (1).
Andrea J. Cohen, York E. Miller
openaire   +3 more sources

Genetically engineered exosomes display RVG peptide and selectively enrich a neprilysin variant: a potential formulation for the treatment of Alzheimer’s disease

Journal of drug targeting (Print), 2021
Exosome is a promising next generation nano-based drug delivery vehicle. However, the unknown molecular mechanisms underlying its natural tissue tropism and the relatively low quantity of naturally enriched molecules of therapeutic value hamper exosome’s
Yongsui Yu, Wei Li, L. Mao, Wanling Peng, Dandan Long, Dongmei Li, Rui Zhou, Xitong Dang   +7 more
semanticscholar   +1 more source