Results 301 to 310 of about 25,082 (343)
Copper Downregulates Neprilysin Activity Through Modulation of Neprilysin Degradation [PDF]
Journal of Alzheimer's Disease, 2010 Copper plays a central role in conserved processes such as respiration, and in highly specialized processes, such as protein modification. The metalloprotease neprilysin (NEP) degrades a variety of bioactive peptides and is involved in many physiological processes. However, very little is known about the regulation of NEP activity. In the current study,
Huan Yang +6 more
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Journal of the American College of Cardiology, 2016 Neprilysin is a zinc-dependent endopeptidase. It is ubiquitous in distribution and promiscuous in function, with >50 putative peptide substrates with varying levels of in vitro and/or in vivo evidence of functional relevance. In the first part of this review, we discuss the genetic, structural, substrate, and pathophysiological aspects of neprilysin ...
Antoni Bayes-genis, A Mark Richards
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Tat peptides inhibit neprilysin
Journal of Neurovirology, 2006Dementia associated with human immunodeficiency virus (HIV) infection occurs commonly in the aging population and amyloid depositions are noted in the brains of patients with HIV infection in younger age groups. This suggests a dysregulation of amyloid processing in the setting of HIV infection.
Abigail Daily +2 more
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Neprilysin: Indications, Expectations, and Challenges
Revista Española de Cardiología (English Edition), 2016La neprilisina ha pasado a ser uno de los centros de interes en cardiologia, debido a los impresionantes beneficios que se han demostrado con la combinacion de una inhibicion de la neprilisina y un antagonismo de los receptores de la angiotensina en el reciente ensayo clinico PARADIGM-HF, en el que se evaluo el empleo de LCZ696 (denominado ahora ...
Antoni Bayes-Genis, Josep Lupón
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Neprilysin Inhibitors in Cardiovascular Disease
Current Cardiology Reports, 2017Mortality from heart failure remains high despite advances in medical therapy over the last three decades. Angiotensin receptor-neprilysin inhibitor (ARNI) combinations are the latest addition to the heart failure medical armamentarium, which is built on the cornerstone regimen of beta blockers, angiotensin converting enzyme (ACE) inhibitors ...
Dipanjan Banerjee, Guson Kang
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Neuroendocrine Differentiation, Neuropeptides, and Neprilysin
American Journal of Respiratory Cell and Molecular Biology, 1999Pulmonary neuroendocrine cells exhibit highly specialized differentiation with a neurosecretory phenotype and significant bioactive peptide hormone content. In addition to these functions, pulmonary neuroendocrine cells have been demonstrated to act as chemoreceptors for hypoxia (1).
Andrea J. Cohen, York E. Miller
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Neprilysin activity and expression are controlled by nicastrin
Journal of Neurochemistry, 2006AbstractWe recently demonstrated that the presenilin‐dependent γ‐secretase complex regulates the expression and activity of neprilysin, one of the main enzymes that degrade the amyloid β‐peptide (Aβ) which accumulates in Alzheimer's disease. Here, we examined the influence of endogenous nicastrin (NCT), a member of the γ‐secretase complex, on ...
Chih-wen Lin
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The Neprilysin Family in Health and Disease
2006The mammalian neprilysin (NEP) family comprises at least seven members: NEP itself, Kell blood group antigen (KELL), the endothelin-converting enzymes (ECE-1 and ECE-2), the enzyme PEX, associated with X-linked hypophosphataemia, "X-converting enzyme" (XCE) a CNS-expressed orphan peptidase and a soluble, secreted endopeptidase (SEP).
Carolyn D. Brown +3 more
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Cell-specific activity of neprilysin 2 isoforms and enzymic specificity compared with neprilysin
Biochemical Journal, 2002Neprilysin (NEP) 2 is a recently cloned glycoprotein displaying a high degree of sequence identity with neprilysin (EC 3.4.24.11), the prototypical member of the M13 subfamily of metalloproteases. Whereas NEP is involved in the metabolism of several bioactive peptides by plasma membranes of various cells, the enzymic properties and physiological ...
Jean-Charles Schwartz +4 more
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Metabolic Regulation of Brain Aβ by Neprilysin [PDF]
Science, 2001 Amyloid β peptide (Aβ), the pathogenic agent of Alzheimer's disease (AD), is a physiological metabolite in the brain. We examined the role of neprilysin, a candidate Aβ-degrading peptidase, in the metabolism using neprilysin gene-disrupted mice. Neprilysin deficiency resulted in defects both in the degradation of exogenously administered Aβ and in the ...
Emi Hama +9 more
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