Results 311 to 320 of about 26,327 (353)
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Tat peptides inhibit neprilysin
Journal of Neurovirology, 2006Dementia associated with human immunodeficiency virus (HIV) infection occurs commonly in the aging population and amyloid depositions are noted in the brains of patients with HIV infection in younger age groups. This suggests a dysregulation of amyloid processing in the setting of HIV infection.
Abigail Daily +2 more
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Neprilysin: Indications, Expectations, and Challenges
Revista Española de Cardiología (English Edition), 2016La neprilisina ha pasado a ser uno de los centros de interes en cardiologia, debido a los impresionantes beneficios que se han demostrado con la combinacion de una inhibicion de la neprilisina y un antagonismo de los receptores de la angiotensina en el reciente ensayo clinico PARADIGM-HF, en el que se evaluo el empleo de LCZ696 (denominado ahora ...
Antoni Bayes-Genis, Josep Lupón
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Neuroendocrine Differentiation, Neuropeptides, and Neprilysin
American Journal of Respiratory Cell and Molecular Biology, 1999Pulmonary neuroendocrine cells exhibit highly specialized differentiation with a neurosecretory phenotype and significant bioactive peptide hormone content. In addition to these functions, pulmonary neuroendocrine cells have been demonstrated to act as chemoreceptors for hypoxia (1).
Andrea J. Cohen, York E. Miller
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Neprilysin Inhibitors in Cardiovascular Disease
Current Cardiology Reports, 2017Mortality from heart failure remains high despite advances in medical therapy over the last three decades. Angiotensin receptor-neprilysin inhibitor (ARNI) combinations are the latest addition to the heart failure medical armamentarium, which is built on the cornerstone regimen of beta blockers, angiotensin converting enzyme (ACE) inhibitors ...
Dipanjan Banerjee, Guson Kang
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The Neprilysin Family in Health and Disease
2006The mammalian neprilysin (NEP) family comprises at least seven members: NEP itself, Kell blood group antigen (KELL), the endothelin-converting enzymes (ECE-1 and ECE-2), the enzyme PEX, associated with X-linked hypophosphataemia, "X-converting enzyme" (XCE) a CNS-expressed orphan peptidase and a soluble, secreted endopeptidase (SEP).
Carolyn D. Brown +3 more
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Cell-specific activity of neprilysin 2 isoforms and enzymic specificity compared with neprilysin
Biochemical Journal, 2002Neprilysin (NEP) 2 is a recently cloned glycoprotein displaying a high degree of sequence identity with neprilysin (EC 3.4.24.11), the prototypical member of the M13 subfamily of metalloproteases. Whereas NEP is involved in the metabolism of several bioactive peptides by plasma membranes of various cells, the enzymic properties and physiological ...
Jean-Charles Schwartz +4 more
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Degradation of tropoelastin and skin elastin by neprilysin
Biochimie, 2018Neprilysin is also known as skin fibroblast-derived elastase, and its up-regulation during aging is associated with impairments of the elastic fiber network, loss of skin elasticity and wrinkle formation. However, information on its elastase activity is still limited. The aim of this study was to investigate the degradation of fibrillar skin elastin by
Chiara Luise +7 more
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Neprilysin activity and expression are controlled by nicastrin
Journal of Neurochemistry, 2006AbstractWe recently demonstrated that the presenilin‐dependent γ‐secretase complex regulates the expression and activity of neprilysin, one of the main enzymes that degrade the amyloid β‐peptide (Aβ) which accumulates in Alzheimer's disease. Here, we examined the influence of endogenous nicastrin (NCT), a member of the γ‐secretase complex, on ...
P. St. George-Hyslop +5 more
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Neprilysin and Amyloid Beta Peptide Degradation
Current Alzheimer Research, 2008Neprilysin is a zinc metalloendopeptidase with relatively broad substrate specificity. The enzyme is localized to the plasma membrane of cells where it can function to degrade extracellular peptides. Structural studies show that neprilysin preferentially cleaves peptides on the amino side of hydrophobic amino acids.
Louis B. Hersh, David W. Rodgers
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Endopeptidase-24.11 (Neprilysin) and Relatives [PDF]
, 1996 The renal and intestinal brush border membranes are an abundant source of peptidase and proteinase activities, most of which are zinc metalloenzymes (see e.g. Kenny et al., 1987). These membranes have proved valuable as starting material for purification of these enzymes as well as for investigating their likely physiological functions.
Leonard J. Murphy +3 more
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