Results 311 to 320 of about 25,082 (343)
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Degradation of tropoelastin and skin elastin by neprilysin
Biochimie, 2018Neprilysin is also known as skin fibroblast-derived elastase, and its up-regulation during aging is associated with impairments of the elastic fiber network, loss of skin elasticity and wrinkle formation. However, information on its elastase activity is still limited. The aim of this study was to investigate the degradation of fibrillar skin elastin by
Chiara Luise +7 more
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Neprilysin and Amyloid Beta Peptide Degradation
Current Alzheimer Research, 2008Neprilysin is a zinc metalloendopeptidase with relatively broad substrate specificity. The enzyme is localized to the plasma membrane of cells where it can function to degrade extracellular peptides. Structural studies show that neprilysin preferentially cleaves peptides on the amino side of hydrophobic amino acids.
Louis B. Hersh, David W. Rodgers
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Renin–angiotensin system and neprilysin
2018The advent of drugs able to modulate the renin–angiotensin system (RAS), and more recently the neprilysin inhibitor sacubitril in combination with a RAS blocker, has improved the outcome of many cardiovascular and renal conditions. In particular, heart failure, post-myocardial infarction, and hypertension are the cardiovascular clinical syndromes in ...
João Pedro Ferreira, Patrick Rossignol
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Endopeptidase-24.11 (Neprilysin) and Relatives [PDF]
, 1996 The renal and intestinal brush border membranes are an abundant source of peptidase and proteinase activities, most of which are zinc metalloenzymes (see e.g. Kenny et al., 1987). These membranes have proved valuable as starting material for purification of these enzymes as well as for investigating their likely physiological functions.
Leonard J. Murphy +3 more
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Localization of mature neprilysin in lipid rafts
Journal of Neuroscience Research, 2011AbstractAlzheimer's disease (AD) is characterized by senile plaques caused by amyloid‐β peptide (Aβ) accumulation. It has been reported that Aβ generation and accumulation occur in membrane microdomains, calledlipid rafts, which are enriched in cholesterol and glycosphingolipids.
Chiaki Tanabe +10 more
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Regulation of Thymic Development by Neprilysin Inhibition
1997Development of T lymphocyte is regulated by both thymocyte-stromal cell interactions and production of soluble factors such as cytokines, peptides and hormones. The local concentration of active biological peptides is regulated by a specialized family of enzymes expressed at the cell surface, the ectopeptidases.
Patrick Auberger, Sandrine Guérin
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State of the art on angiotensin-neprilysin inhibitors
Minerva Cardiology and AngiologyAngiotensin receptor neprilysin inhibitor (ARNI) decreases renin-angiotensin-aldosterone system (RAAS) and sympathetic nervous systems (SNS) activity promoting vasodilation, decreasing myocardial hypertrophy and fibrosis. Beyond the SNS, RAAS and natriuretic peptide systems, ARNI results in increased circulatory and myocardial nitric oxide levels ...
Anusha, Sunkara +3 more
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Neprilysin Inhibition for Heart Failure
New England Journal of Medicine, 2014Milton Packer +2 more
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Convoluted molecular maze of neprilysin
Diagnosis, 2022Eleftherios P. Diamandis +2 more
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