Results 61 to 70 of about 14,163 (275)

Randomized multicentre pilot study of sacubitril/valsartan versus irbesartan in patients with chronic kidney disease: United Kingdom Heart and Renal Protection (HARP)- III—rationale, trial design and baseline data [PDF]

, 2016
BACKGROUND: Patients with chronic kidney disease (CKD) are at risk of progression to end-stage renal disease and cardiovascular disease. Data from other populations and animal experiments suggest that neprilysin inhibition (which augments the ...
Baigent, C., Baxter, A., Bethel, A., Bowman, L., Brunskill, N., Cockwell, P., Dayanandan, R., Emberson, J., Haynes, R., Herrington, W.G., Hill, M., Judge, P.K., Kalra, P.A., Knott, C., Landray, M.J., McMurray, John J., Murphy, K., Roderick, P., Staplin, N., Storey, B.C., Taal, M., Tomson, C., Wheatley, K., Wheeler, D.C.   +23 more
core   +1 more source

Neprilysin

JACC: Heart Failure, 2015
Neprilysin (NEP) is a membrane-bound enzyme with a large extracellular component that hydrolyzes atrial natriuretic peptide (ANP), but less so brain natriuretic peptide (BNP), and degrades various very important endogenous vasoactive peptides, including adrenomedullin and bradykinin for ...
Alexandre Mebazaa, Marie-France Seronde
openaire   +3 more sources

Substance P and Neprilysin in Chronic Pancreatitis [PDF]

European Surgical Research, 2012
<b><i>Background/Aims:</i></b> We aimed to analyze substance P (SP) and neprilysin (NEP), the membrane metallopeptidase that degrades SP, in chronic pancreatitis (CP). <b><i>Methods:</i></b> SP and NEP mRNA levels were analyzed by qRT-PCR in tissue samples from 30 patients with CP and 8 organ donors.
Mascetta G., Di Mola F. F., Tavano F., Selvaggi F., Giese N., Bassi C., Buchler M. W., Friess H., Di Sebastiano P.   +8 more
openaire   +5 more sources

Serum neprilysin levels are elevated in preeclampsia

Taiwanese Journal of Obstetrics and Gynecology, 2021
To evaluate the possible associations between serum Neprilysin (NEP) levels and preeclampsia and mild and severe preeclampsia subgroups.Fifty-five consecutive women with mild preeclampsia and fifty-five consecutive women with severe preeclampsia were compared with 110 approximately gestational age-matched (±1 week) women with an uncomplicated pregnancy.
Tüten, Nevin, Malik, Eduard, Gök, Koray, Hamzaoğlu, Kübra, Makul, Melike, Öner, Yahya Özgün, Bulut, Huri, Tüten, Abdullah, Güralp, Onur Şahin   +8 more
openaire   +6 more sources

Use of guideline‐recommended medical therapy in patients with heart failure and chronic kidney disease: from physician's prescriptions to patient's dispensations, medication adherence and persistence

European Journal of Heart Failure, Volume 24, Issue 11, Page 2185-2195, November 2022., 2022
Patients with heart failure and chronic kidney disease are less likely to receive and persist on guideline‐recommended medical therapies. Aim Half of heart failure (HF) patients have chronic kidney disease (CKD) complicating their pharmacological management.
Roemer J. Janse, Edouard L. Fu, Ulf Dahlström, Lina Benson, Bengt Lindholm, Merel van Diepen, Friedo W. Dekker, Lars H. Lund, Juan‐Jesus Carrero, Gianluigi Savarese   +9 more
wiley   +1 more source

Breakthrough in Heart Failure therapy: LCZ696 combining ACE-Neprilysin inhibition

Asian Journal of Medical Sciences, 2017
Background: Current Heart failure (HF) pharmacotherapy has been unsatisfactory in halting disease progression completely. Aims and Objective: To evaluate the role of LCZ696, a recent FDA-approved ACE -Neprilysin inhibitor (ARNi) in the management of ...
Sandeep Lahiry
doaj   +1 more source

Influence of Sacubitril/Valsartan (LCZ696) on 30-day readmission after heart failure hospitalization [PDF]

, 2016
Background: Patients with heart failure (HF) are at high risk for hospital readmission in the first 30 days following HF hospitalization. Objectives: This study sought to determine if treatment with sacubitril/valsartan (LCZ696) reduces rates ...
Claggett, Brian L., Desai, Akshay S., Lefkowitz, Martin, McMurray, John J.V., Packer, Milton, Rouleau, Jean L., Shi, Victor, Solomon, Scott D., Starling, Randall, Swedberg, Karl, Teerlink, John, Zile, Michael R.   +11 more
core   +2 more sources

Activating AhR alleviates cognitive deficits of Alzheimer's disease model mice by upregulating endogenous Aβ catabolic enzyme Neprilysin

Theranostics, 2021
Rationale: Neprilysin (NEP) is a major endogenous catabolic enzyme of amyloid β (Aβ). Previous studies have suggested that increasing NEP expression in animal models of Alzheimer's disease had an ameliorative effect.
Cheng Qian, Chunjie Yang, Mengting Lu, Jiaxin Bao, Haiyan Shen, Bingquan Deng, Shensen Li, Wenwen Li, Mu Zhang, Changchun Cao   +9 more
semanticscholar   +1 more source

Trajectories in New York Heart Association functional class in heart failure across the ejection fraction spectrum: data from the Swedish Heart Failure Registry

European Journal of Heart Failure, Volume 24, Issue 11, Page 2093-2104, November 2022., 2022
Stable New York Heart Association (NYHA) class over time was much more frequent than an improvement or a worsening. Follow‐up NYHA class assessment, but not change in NYHA class over time, was independently associated with better prognosis. CI, confidence interval; HR, hazard ratio.
Felix Lindberg, Lars H. Lund, Lina Benson, Ulf Dahlström, Patric Karlström, Cecilia Linde, Giuseppe Rosano, Gianluigi Savarese   +7 more
wiley   +1 more source

Angiotensin receptor blocker neprilysin inhibitors

World Journal of Cardiology, 2021
Heart failure (HF) is a clinical syndrome that results from a structural or functional cardiac disorder that reduces the ability of the ventricle of the heart to fill with, or eject, blood. It is a multifaceted clinical condition that affects up to 2% of the population in the developed world, and is linked to significant morbidity and mortality; it is ...
Suguru Asako, Ippei Osugi, Tomohisa Nomura, Daisuke Usuda, Manabu Sugita, Kenki Usami, Toshihiro Higashikawa, Shintaro Shimozawa, Keiko Mizuno, Takayuki Komatsu, Risa Katou, Toshihiko Yoshizawa, Sakurako Ito, Shungo Tokunaga, Akihiko Kondo, Hiroki Takami, Yuta Hotchi, Jiro Oba, Kentaro Mishima   +18 more
openaire   +3 more sources