Results 81 to 90 of about 16,895 (259)

Connecting the dots: A narrative review of the relationship between heart failure and cognitive impairment

ESC Heart Failure, Volume 12, Issue 2, Page 1119-1131, April 2025.
Abstract Large clinical data underscore that heart failure is independently associated to an increased risk of negative cognitive outcome and dementia. Emerging evidence suggests that cerebral hypoperfusion, stemming from reduced cardiac output and vascular pathology, may contribute to the largely overlapping vascular dementia and Alzheimer's disease ...
Mauro Massussi, Maria Giulia Bellicini, Marianna Adamo, Andrea Pilotto, Marco Metra, Alessandro Padovani, Riccardo Proietti   +6 more
wiley   +1 more source

Sacubitril/valsartan preserves regional cardiac function following myocardial infarction in rats

ESC Heart Failure, Volume 12, Issue 2, Page 1304-1315, April 2025.
Parts of the figure were drawn by using pictures from Servier Medical Art. Servier Medical Art by Servier is licensed under a Creative Commons Attribution 3.0 Unported License (https://creativecommons.org/licenses/by/3.0/). Abstract Aims Sacubitril/valsartan (Sac/Val) is used for treatment of heart failure. The effect of Sac/Val on regional dysfunction
Einar Sjaastad Nordén, Bård Andre Bendiksen, Kaja Knudsen Bergo, Emil Knut Stenersen Espe, Gary McGinley, Almira Hasic, Ida Marie Hauge‐Iversen, Hege Katrin Ugland, Xin Shen, Michael Frisk, Nishani S. Mabotuwana, William E. Louch, Rizwan I. Hussain, Lili Zhang, Ivar Sjaastad, Alessandro Cataliotti, Geir Christensen   +16 more
wiley   +1 more source

Reshaping [^99mTc]Tc-DT11 to DT14D Tagged with Trivalent Radiometals for NTS₁R-Positive Cancer Theranostics

Pharmaceutics
Background/Objectives: Radiotheranostics of neurotensin subtype 1 receptor (NTS1R)-expressing tumors, like pancreatic, gastrointestinal, or prostate cancer, has attracted considerable attention in recent years. Still, the fast degradation of neurotensin (
Panagiotis Kanellopoulos, Berthold A. Nock, Eric P. Krenning, Theodosia Maina   +3 more
doaj   +1 more source

FDG PET/CT imaging and circulating biomarkers of inflammation in desmoplakin cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1485-1489, April 2025.
Abstract Aims Inflammation has been implicated in the pathogenesis of desmoplakin (DSP) cardiomyopathy, and retrospective studies have described abnormal myocardial fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) findings in symptomatic patients eventually diagnosed with DSP cardiomyopathy.
Sanjay Divakaran, Vinay Randhawa, Usman A. Tahir, Matthew Robertson, Anam A. Waheed, Anna Perillo, Leanne Barrett, Ron Blankstein, Mark W. Feinberg, Marcelo F. Di Carli, Neal K. Lakdawala   +10 more
wiley   +1 more source

Role of Prenatal Hypoxia in Brain Development, Cognitive Functions, and Neurodegeneration

Frontiers in Neuroscience, 2018
This review focuses on the role of prenatal hypoxia in the development of brain functions in the postnatal period and subsequent increased risk of neurodegenerative disorders in later life. Accumulating evidence suggests that prenatal hypoxia in critical
Natalia N. Nalivaeva, Natalia N. Nalivaeva, Anthony J. Turner, Igor A. Zhuravin, Igor A. Zhuravin   +4 more
doaj   +1 more source

DECREASED NEUROPEPTIDASE NEPRILYSIN EXPRESSION CORRELATES WITH ACCUMULATION OF AMYLOID Аβ PEPTIDE AND IMPAIRMENT OF MORPHO-FUNCTIONAL CHARACTERISTICS IN THE BRAIN DIVISIONS OF 5XFAD MICE MODELLING PATHOGENESIS OF ALZHEIMER’S DISEASE

, 2021
N. М. Dubrovskaya, Dmitri Vasilev, Н. Л. Туманова, Natalia N. Nalivaeva   +3 more
openalex   +1 more source

Cilostazol in patients with heart failure and preserved ejection fraction—The CLIP‐HFpEF trial

ESC Heart Failure, Volume 12, Issue 2, Page 1437-1446, April 2025.
• Cilostazol is an oral PDE‐3 inhibitor that may have advantageous effects in heart failure with preserved ejection fraction (HFpEF). • Cilostazol significantly improved short‐term heart failure‐related health status scores (KCCQ‐12) and NT‐proBNP levels when compared to placebo.
Norman Aiad, Jeanne du Fay de Lavallaz, Michael J. Zhang, Thanat Chaikijurajai, Bo Ye, Prabhjot S. Nijjar, Julie A. Lahiri, Cindy M. Martin, Tamas Alexy, Markus Meyer   +9 more
wiley   +1 more source

Angiotensin Receptor–Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction: Lessons from PARAGON-HF [PDF]

, 2020
Muthiah Vaduganathan, John J.V. McMurray, Scott D. Solomon   +2 more
openalex   +1 more source

Potential neuroprotective and therapeutic agents and their mechanisms for irradiation‐induced brain injury

Ibrain, EarlyView.
In this review, agents such baicalein, troxerutin, epigallocatechin gallate, quercetin, melatonin, valproic acid, lithium, neurosteroid progesterone, as well as minocycline have been implicated as neuroprotective agents for irradiation‐induced neurological deficits. Also, agents such as glucocorticoids, methylphenidate, vitamin E, bisdemethoxycurcumin,
Seidu A. Richard, Vivian Kapio Abem, Sagor Kumar Roy   +2 more
wiley   +1 more source

Adipose‐derived small extracellular vesicles exacerbate microvascular dysfunction in heart failure with preserved ejection fraction via mmu‐miR‐582‐3p‐mediated Rap1b suppression

Interdisciplinary Medicine, EarlyView.
This study reveals that small extracellular vesicles (sEVs) from visceral fat compromise coronary microcirculation in a mouse model of heart failure with preserved ejection fraction (HFpEF). The SGLT2 inhibitor canagliflozin emerges as a therapeutic strategy, improving cardiac function and endothelial health.
Lu Chen, Qiuhan Wang, Mengjia Shen, Mingjue Li, Yingqi Zhu, Cankun Zheng, Siyuan Ma, Hairuo Lin, Xiaokang Fu, Rui Zhang, Jianping Bin, Yulin Liao, Qiancheng Wang   +12 more
wiley   +1 more source