Results 71 to 80 of about 2,114,959 (246)

New Heterostilbene and Triazole Oximes as Potential CNS-Active and Cholinesterase-Targeted Therapeutics

Biomolecules
New furan, thiophene, and triazole oximes were synthesized through several-step reaction paths to investigate their potential for the development of central nervous systems (CNS)-active and cholinesterase-targeted therapeutics in organophosphorus ...
Milena Mlakić, Tena Čadež, Goran Šinko, Irena Škorić, Zrinka Kovarik   +4 more
doaj   +1 more source

Analysis of chemical warfare agents by gas chromatography-mass spectrometry: methods for their direct detection and derivatization approaches for the analysis of their degradation products

Reviews in Analytical Chemistry, 2017
Chemical warfare agents (CWAs) are unarguably one of the most feared toxic substances produced by mankind. Their inception in conventional warfare can be traced as far back as the Middle Ages but their full breakthrough as central players in bellic ...
Valdez Carlos A., Leif Roald N., Hok Saphon, Hart Bradley R.   +3 more
doaj   +1 more source

Nerve agents poisoning and its treatment in schematic figures and tables /

, 2012
Organophosphate compounds, first synthesized in the 1800s, have been used for insecticides, pesticides, and in war and terrorism, such as the 1995 Tokyo subway poisoning.
Bajgar, Jiří
core  

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Persistently Elevated Gamma Power and Delayed Brain Damage in Aged Rats Acutely Exposed to Soman Without Status Epilepticus: Comparisons with Seizing Rats Treated with Midazolam or with Tezampanel and Caramiphen

Toxics
Aged animals or humans are more susceptible to permanent brain damage from status epilepticus (SE), making the selection of antiseizure medication even more crucial.
Taiza H. Figueiredo, Vassiliki Aroniadou-Anderjaska, Marcio De Araujo Furtado, Volodymyr I. Pidoplichko, Katia Rossetti, Lucille A. Lumley, Maria F. M. Braga   +6 more
doaj   +1 more source

Characterization of the key membrane protein cytochrome Cyc2 from Ghiorsea bivora

FEBS Open Bio, EarlyView.
This study reports the first detailed biochemical analysis of Cyc2TAG1_1, a cytochrome protein involved in microbial iron oxidation. We produced and purified this enzyme in E. coli, then measured its iron‐oxidizing efficiency, and characterized its electrical and structural properties.
Josiane Azizi, Alain Dolla, Frauke Baymann, Celine Rommevaux, Latifa Elantak, Helene Gaussier, Matthieu Nouailler   +6 more
wiley   +1 more source

The prediction of hydrolysis and biodegradation of organophosphorus-based chemical warfare agents (G-series and V-series) using toxicology in silico methods

Ecotoxicology and Environmental Safety
Nerve agents (G- and V-series) are a group of extremely toxic organophosphorus chemical warfare agents that we have had the opportunity to encounter many times on a massive scale (Matsumoto City, Tokyo subway and Gulf War).
Maciej Noga, Agata Michalska, Kamil Jurowski   +2 more
doaj   +1 more source

Complex View on Poisoning with Nerve Agents and Organophosphates

Acta Medica, 2005
OP/nerve agents are still considered as important chemicals acting on living organisms and widely used in human practice. Nerve agents are the most lethal chemical warfare agents.
Jiří Bajgar
doaj   +1 more source

DETERMINANTS OF NERVE CONDUCTION RECOVERY AFTER NERVE INJURIES: COMPRESSION DURATION AND NERVE FIBER TYPES

, 2017
Introduction: The aims of this study were to determine the influences of: (1) timing of nerve decompression; and (2) nerve fiber types on the patterns of nerve conduction studies (NCS) after nerve injury.
Tseng, To-Jung;Hsiao, Tin-Hsin;Hsieh, Sung-Tsang;Hsieh, Yu-Lin, 謝松蒼   +1 more
core   +1 more source