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Reactive Fibroblasts in Response to Optic Nerve Crush Injury
Molecular Neurobiology, 2020Traumatic optic neuropathy leads to bidirectional degeneration of retinal ganglion cells and axons and results in optic nerve scaring, which inhibits the regeneration of damaged axons. Compared with its glial counterpart, the fibrotic response causing nerve scar tissue is poorly permissive to axonal regeneration. Using collagen1α1-GFP reporter mice, we
Xiangxiang Liu +7 more
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Protective effect of paeoniflorin against optic nerve crush
Journal of Huazhong University of Science and Technology [Medical Sciences], 2007In order to evaluate the efficacy of traditional paeonia extract paeoniflorin against optic nerve crush, 16 Brown Norway rats were divided into two groups at random, with 8 rats in each group. In paeoniaflorin-treated group, 2 mg paeoniaflorin (total volume: 1 mL) was injected into rat's peritoneum one time a day for a period of 8 days.
Jing, Li, Xinchun, Xiong, Yunhai, Liu
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Delivery of an Adenoviral Vector to the Crushed Recurrent Laryngeal Nerve
The Laryngoscope, 2003AbstractObjectives Objectives were to create a model of recurrent laryngeal nerve injury for testing the efficacy of potential therapeutic viral gene therapy vectors and to demonstrate that remote injection of a viral vector does not cause significant additional neuronal injury.Study Design Animal model.Methods Rats were randomly assigned to three ...
Adam, Rubin +6 more
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Reinnervation of cat pacinian corpuscles after nerve crush
Acta Neuropathologica, 1997The reinnervation pattern of crural pacinian corpuscles was examined by light and electron microscopy in eight adult cats of both sexes 3-18 months after sciatic nerve crush. Normal pacinian corpuscles are each supplied with a single myelinated axon and a single cylindrical axon terminal which may branch in the distal part of the inner core ...
J, Zelená, G, Zacharová
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The Effect of Coenzyme Q10 on the Regeneration of Crushed Facial Nerve
Journal of Craniofacial Surgery, 2015The aim of this study is to show the possible positive effect of coenzyme Q10 (Co Q10) on regenerating in facial palsy.Sixteen female Sprague-Dawley albino rats were randomly divided into 2 groups as Co Q10 and control groups. Group Q10 (n = 8) received Co Q10 of 10 mg/kg/d intraperitoneally for 30 days, and group C (n = 8) received saline solution of ...
Güven, Yildirim +7 more
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Crushing of phrenic nerve and multiple costotomies
The American Journal of Surgery, 1945Abstract The repair of a large incisional hernia, which could not be accomplished by the usual methods, was made possible by two additional procedures, (1) crushing of the phrenic nerve, and (2) multiple costotomies. 1. 1. Crushing of the phrenic nerve produced an elevation of the diaphragm which provided more room in the abdominal cavity and ...
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A comparison of cryoprobe and crush lesions in the rat sciatic nerve
Pain, 1991This study examines the behavioral, sensory, motor and structural recovery during the first 2 months following a freeze (cryoprobe) lesion compared to a nerve crush (forceps). There is a complete loss of sensory and motor function following either type of lesion during the first 2 weeks of recovery.
James M, Kerns +4 more
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A Rat Model for Intracranial Facial Nerve Crush Injuries
Otolaryngology–Head and Neck Surgery, 2011Objective(1) Explain the need for an animal model to study intracranial injuries to the facial nerve. (2) Describe various techniques attempted to identify and crush the intracranial segment of the facial nerve in a rat model. (3) Describe in detail a successful rat model of intracranial facial nerve crush injury.Study DesignRandomized controlled ...
Ryan C, Burgette +7 more
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Chronic Nerve Compression Model for the Double Crush Hypothesis
Annals of Plastic Surgery, 1991"Double crush hypothesis" is a phrase that has entered clinical use based on a hypothesis presented by Upton and McComas in 1973. Although clinical examples of the double crush are appearing more frequently, there has been no experimental proof of this hypothesis as it relates to chronic nerve compression.
A L, Dellon, S E, Mackinnon
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Single vs multiple somatic nerve crushes in the rat
Brain Research, 1987Nerve lesions modify regenerative responses to subsequent lesions. Some of the modifications might be useful. To increase our understanding of these modifications, the present study determines myelinated and unmyelinated axon numbers in the distal part of rat sciatic nerve and in 2 smaller branches, the nerve to the medial gastrocnemius muscle and the ...
C B, Jenq, R E, Coggeshall
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