Results 121 to 130 of about 2,724,357 (343)

Dynamic Regulation of Schwann Cell Enhancers after Peripheral Nerve Injury*

open access: yesJournal of Biological Chemistry, 2015
Background: Nerve injury induces Schwann cells to remove myelin coating and secrete factors that stimulate nerve regeneration. Results: ChIP-seq was used to identify injury-regulated enhancers in peripheral nerve.
Holly A Hung   +3 more
semanticscholar   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

open access: yesAdvanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth   +2 more
wiley   +1 more source

Polymer‐Incorporated Mechanically Compliant Carbon Nanotube Microelectrode Arrays for Multichannel Neural Signal Recording

open access: yesAdvanced Functional Materials, EarlyView.
This work presents a soft microelectrode array based on vertically aligned carbon nanotube (CNT) forests, combining high conductivity with mechanical softness. A densification process and air‐pressure‐assisted flexibilization improve structural integrity, ensuring stable insertion and reduced inflammation.
Hyeonhee Roh   +8 more
wiley   +1 more source

Buckling‐Resistant and Trace‐Stacked (BRATS) Design Enables Aid‐Free Implantation of Flexible Multielectrode Array with Minimized Inflammatory Tissue Response

open access: yesAdvanced Functional Materials, EarlyView.
Buckling‐resistant and trace‐stacked (BRATS) intracortical microelectrode arrays (MEAs) eliminate the need for insertion aid and complex surgical setup, resulting in minimal inflammatory tissue response, compared to conventional flexible MEAs inserted with aid. Trace stacking effectively doubled the channel count without increasing the MEA shank width,
May Yoon Pwint, Delin Shi, X. Tracy Cui
wiley   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

open access: yesAdvanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz   +3 more
wiley   +1 more source

Smart Polymeric 3D Microscaffolds Hosting Spheroids for Neuronal Research via Quantum Metrology

open access: yesAdvanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
Development of a platform consisting of 3D microscaffolds supporting 3D embryoid bodies for neuronal research. The polymeric scaffolds enable directed growth of neurites. This study shows nanodiamond‐based quantum sensors graft onto the polymer material, enabling quantum metrology experiments within the 3D neuronal model and thereby providing a ...
Beatriz N. L. Costa   +5 more
wiley   +1 more source

Engineering the Future of Restorative Clinical Peripheral Nerve Surgery

open access: yesAdvanced Healthcare Materials, EarlyView.
What if damaged nerves could regenerate more effectively? This review unveils cutting‐edge strategies to restore nerve function, from biomaterial scaffolds and bioactive molecules to living engineered tissues. By accelerating axonal regrowth, preserving Schwann cells, and enhancing connectivity, these approaches are reshaping nerve repair—offering new ...
Justin C. Burrell   +5 more
wiley   +1 more source

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