Results 71 to 80 of about 3,082,625 (411)

Amyotrophic Lateral Sclerosis: Molecular Mechanisms, Biomarkers, and Therapeutic Strategies

Antioxidants, 2021
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with the progressive loss of motor neurons, leading to a fatal paralysis. According to whether there is a family history of ALS, ALS can be roughly divided into two types: familial and ...
Xiaoming Yang, Yanan Ji, Wei Wang, Lilei Zhang, Zehao Chen, Miaomei Yu, Yuntian Shen, Fei Ding, Xiaosong Gu, Hualin Sun   +9 more
doaj   +1 more source

Shoulder posture and median nerve sliding [PDF]

, 2004
Background: Patients with upper limb pain often have a slumped sitting position and poorshoulder posture. Pain could be due to poor posture causing mechanical changes (stretch; localpressure) that in turn affect the function of major limb nerves (e.g ...
A Dilley, A Dilley, EF Pascarelli, GP Szeto, J Greening, M Marcus, P Griegel-Morris, PW Buckle, R Grewel, SE Mackinnon   +9 more
core   +3 more sources

Nerve injury in severe trauma with upper extremity involvement: evaluation of 49,382 patients from the TraumaRegister DGU® between 2002 and 2015

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2018
BackgroundPeripheral nerve injury (PNI) as an adjunct lesion in patients with upper extremity trauma has not been investigated in a Central European setting so far, despite of its devastating long-term consequences.
T. Huckhagel, J. Nüchtern, J. Regelsberger, R. Lefering   +3 more
semanticscholar   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Morphology and Nanomechanics of Sensory Neurons Growth Cones following Peripheral Nerve Injury [PDF]

, 2012
A prior peripheral nerve injury in vivo, promotes a rapid elongated mode of sensory neurons neurite regrowth in vitro. This in vitro model of conditioned axotomy allows analysis of the cellular and molecular mechanisms leading to an improved neurite re ...
A Nilsson, A Vinckier, AB Huber, AB Mathur, AL Weisenhorn, AR Bausch, Attila-Gergely Végh, B Geiger, C Hilaire, ChC Dupont-Gillain, Csilla Gergely, DM Suter, DS Smith, E Evans, E Spedden, EW Dent, F Charron, Frédérique Scamps, H-J Butt, HA McNally, HA McNally, HJ Song, HS Xiao, I Mechaly, Igor Sokolov, IN Sneddon, J Dai, J Laishram, J Sleep, JL Goldberg, K Tanaka, KD Costa, L Lankford K, M Mustata, M Radmacher, M Radmacher, Marta Martin, MG Hertz, MJ Rosenbluth, Olivier Lucas, Ouafa Benzina, OV Chumakova, PN Hoffman, R García, R Lal, S Andre, S Pieraut, S Pieraut, SS Hannila, T Araki, T Tojima, TC Dickson, Thierry Cloitre, TS Lanero, V Heinrich, Vivien Szabo, Y Xiong, ZL Chen   +57 more
core   +9 more sources

The Schwann cell-specific G-protein Gαo (Gnao1) is a cell-intrinsic controller contributing to the regulation of myelination in peripheral nerve system

Acta Neuropathologica Communications
Myelin sheath abnormality is the cause of various neurodegenerative diseases (NDDs). G-proteins and their coupled receptors (GPCRs) play the important roles in myelination. Gnao1, encoding the major Gα protein (Gαo) in mammalian nerve system, is required
Jinghui Xu, Qianqian Peng, Jieyi Cai, Jianghong Shangguan, Wenfeng Su, Gang Chen, Hualin Sun, Changlai Zhu, Yun Gu   +8 more
doaj   +1 more source

The Effects of Surgical Antiseptics and Time Delays on RNA Isolated From Human and Rodent Peripheral Nerves

Frontiers in Cellular Neuroscience, 2019
Peripheral Nerve Injury (PNI) is common following blunt or penetrating trauma with an estimated prevalence of 2% among the trauma population. The resulting economic and societal impacts are significant.
Matthew Wilcox, Matthew Wilcox, Matthew Wilcox, Tom J. Quick, Tom J. Quick, Tom J. Quick, James B. Phillips, James B. Phillips   +7 more
doaj   +1 more source

Biodegradable materials for bone defect repair

Military Medical Research, 2020
Compared with non-degradable materials, biodegradable biomaterials play an increasingly important role in the repairing of severe bone defects, and have attracted extensive attention from researchers.
Shuai Wei, Jian-Xiong Ma, Lai Xu, Xiao-Song Gu, Xin-Long Ma   +4 more
doaj   +1 more source

Intradiscal injection for the management of low back pain

JOR Spine, 2022
Low back pain (LBP) is a common clinical problem and a major cause of physical disability, imposing a prominent socioeconomic burden. Intervertebral disc degeneration (IDD) has been considered the main cause of LBP.
Fu Zhang, Songjuan Wang, Baoliang Li, Wei Tian, Zhiyu Zhou, Shaoyu Liu   +5 more
doaj   +1 more source

Rapid Isolation of Dorsal Root Ganglion Macrophages. [PDF]

, 2019
There are growing interests to study the molecular and cellular interactions among immune cells and sensory neurons in the dorsal root ganglia after peripheral nerve injury.
Guan, Zhonghui, Leff, Jacqueline, Yu, Xiaobing   +2 more
core